“…Chitosan oligosaccharide (COS) is derived by the hydrolysis and deacetylation of chitin, a polymer of N-acetyl-D-glucosamine, which is a main constituent of the exoskeleton of arthropods such as insects, crabs and shrimps, and the cell wall of fungi [ 15 , 16 , 17 , 18 , 19 ]. The physico-chemical and biological properties of this biopolymer have been explored in various fields including pharmaceuticals, biotechnology, textiles, cosmetics, biomedical engineering, agriculture, food processing, nutrition, water, and wastewater treatments [ 20 , 21 , 22 , 23 ]. Due to its favorable pharmacokinetics and beneficial biological activities including anti-oxidative, anti-inflammatory, anti-diabetic, anti-bacterial, and anti-cancer activities, COS has the potential for development as dietary supplements or nutraceuticals [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ].…”