Polyrotaxane/gold nanoparticle hybrid nanomaterials as anticancer drug delivery systems

Adeli, Mohsen; Sarabi, R. Sadeghi; Farsi, Raziyeh Yadollahi; Kalantari, Mahdieh

doi:10.1039/c1jm12412a

Cited by 41 publications

(30 citation statements)

References 44 publications

(44 reference statements)

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“…The CLSM images clearly indicated that the system could deliver PEI/ β ‐CDs@camptothecin complexes within cells in situ to induce cell apoptosis. Other types of CDs‐based supramolecular nanosystems were prepared by crosslinking quantum dots21 or gold nanoparticles22 with pseudopolyrotaxanes composed of α ‐CDs and PEG chains. Through the incorporation of cis ‐platin drugs into the above supramolecular nanosystems, the resulting drug delivery systems were capable of high‐efficient delivery of drugs into cancer cells and release of drugs in a controllable manner.…”

Section: Cyclodextrinsmentioning

confidence: 99%

Host–Guest Supramolecular Nanosystems for Cancer Diagnostics and Therapeutics

et al. 2013

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Extensive efforts have been devoted to the construction of functional supramolecular nanosystems for applications in catalysis, energy conversion, sensing and biomedicine. The applications of supramolecular nanosystems such as liposomes, micelles, inorganic nanoparticles, carbon materials for cancer diagnostics and therapeutics have been reviewed by other groups. Here, we will focus on the recent momentous advances in the implementation of typical supramolecular hosts (i.e., cyclodextrins, calixarenes, cucurbiturils and metallo-hosts) and their nanosystems in cancer diagnostics and therapeutics. We discuss the evolutive process of supramolecular nanosystems from the structural control and characterization to their diagnostic and therapeutic function exploitation and even the future potentials for clinical translation.

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Section: Cyclodextrinsmentioning

confidence: 99%

Host–Guest Supramolecular Nanosystems for Cancer Diagnostics and Therapeutics

et al. 2013

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“…The use of various cyclodextrins for the synthesis of AuNPs has been previously reported [72][73][74] . Furthermore, numerous nanometric systems have been designed, in which AuNPs are covered by modified CDs for potential biological applications [23][24][25][75][76][77] .…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles Interacting with β-Cyclodextrin–Phenylethylamine Inclusion Complex: A Ternary System for Photothermal Drug Release

Sierpe

Lang

Jara

et al. 2015

ACS Appl. Mater. Interfaces

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We report the synthesis of a 1:1 β-cyclodextrin-phenylethylamine (βCD-PhEA) inclusion complex (IC) and the adhesion of gold nanoparticles (AuNPs) onto microcrystals of this complex, which forms a ternary system. The formation of the IC was confirmed by powder X-ray diffraction and NMR analyses ((1)H and ROESY). The stability constant of the IC (760 M(-1)) was determined using the phase solubility method. The adhesion of AuNPs was obtained using the magnetron sputtering technique, and the presence of AuNPs was confirmed using UV-vis spectroscopy (surface plasmon resonance effect), which showed an absorbance at 533 nm. The powder X-ray diffractograms of βCD-PhEA were similar to those of the crystals decorated with AuNPs. A comparison of the one- and two-dimensional NMR spectra of the IC with and without AuNPs suggests partial displacement of the guest to the outside of the βCD due to attraction toward AuNPs, a characteristic tropism effect. The size, morphology, and distribution of the AuNPs were analyzed using TEM and SEM. The average size of the AuNPs was 14 nm. Changes in the IR and Raman spectra were attributed to the formation of the complex and to the specific interactions of this group with the AuNPs. Laser irradiation assays show that the ternary system βCD-PhEA-AuNPs in solution enables the release of the guest.

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“…Because cyclodextrins have strong host-guest relationships, they can be used as biocompatible carriers. Adeli et al formed pseudopolyrotaxanes through hydrophobic interactions between the end of the triazine groups of PEG (conjugated onto AuNRs) and the α-cyclodextrin cavity [52]. These pseudopolyrotaxanes interact noncovalently through the end functional groups of PEG with the citrate shell of the AuNPs, constituting a hybrid system.…”

Section: Liberation Of the Drug From A Polymer Matrixmentioning

confidence: 98%

Gold Nanoparticles for Photothermally Controlled Drug Release

Guerrero

Hassan

Escobar

et al. 2014

Nanomedicine (Lond.)

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In this article, we describe how nanoparticles work in photothermally triggered drug delivery, starting with a description of the plasmon resonance and the photothermal effect, and how this is used to release a drug. Then, we describe the four major functionalization strategies and each of their different applications. Finally, we discuss the biodistribution and toxicity of these systems and the necessary requirements for the use of gold nanoparticles for spatially and temporally controlling drug release through the photothermal effect.

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Polyrotaxane/gold nanoparticle hybrid nanomaterials as anticancer drug delivery systems

Cited by 41 publications

References 44 publications

Host–Guest Supramolecular Nanosystems for Cancer Diagnostics and Therapeutics

Host–Guest Supramolecular Nanosystems for Cancer Diagnostics and Therapeutics

Gold Nanoparticles Interacting with β-Cyclodextrin–Phenylethylamine Inclusion Complex: A Ternary System for Photothermal Drug Release

Gold Nanoparticles for Photothermally Controlled Drug Release

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