Polyradiculopathy Due to Methotrexate-Induced Ebv-Associated Lymphoproliferative Disorder

Kumar, Nidhish; Sandroni, Paola; Steensma, David P.; Luthra, H. S.; Habermann, Thomas M.

doi:10.1212/01.wnl.0000334757.16882.37

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…8 While previous reports have dismissed these toxicities as transient phenomena, 9 recent findings indicate that many survivors have impaired neuromuscular function that persists after treatment has ended. 9–14 Among these survivors, long-term dysfunction includes slowed motor nerve conduction velocities, 10, 12–14 absent deep tendon reflexes, 15 limited ankle range of motion 11 and distal muscle weakness.…”

Section: Introductionmentioning

confidence: 99%

Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia

Ness

Hudson

Pui

et al. 2011

Cancer

125

134

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Introduction Treatment regimens for childhood acute lymphoblastic leukemia (ALL) contain neurotoxic agents that may interfere with neuromuscular health. This study examined associations between neuromuscular impairments and physical function, and between neuromuscular impairments, and doses of vincristine and intrathecal methotrexate used to treat leukemia among survivors of childhood ALL. Methods ALL survivors 10+ years from diagnosis participated in neuromuscular performance testing. Treatment data were abstracted from medical records. Regression models were used to evaluate associations between treatment factors, neuromuscular impairments and physical performance. Results Among 415 survivors (median age 35 years; range 21–52), balance, mobility and six-minute walk (6MW) distances were 1.3 standard deviations below age- and sex-specific values in 15.4%, 3.6% and 46.5% of participants, respectively. Impairments included absent Achilles tendon reflexes (39.5%), active dorsiflexion range of motion (ROM) < 5 degrees (33.5%) and impaired knee extension strength (30.1%). In adjusted models (including cranial radiation), survivors treated with intrathecal methotrexate cumulative doses 215+ mg/m2 were 3.4 (95% CI 1.2–9.8) times more likely than survivors who received no intrathecal methotrexate, and those who received vincristine cumulative doses 39+ mg/m2 1.5 (95% CI 1.0–2.5) times more likely than those who received lower doses to have impaired ROM. Higher intrathecal methotrexate doses were associated with reduced knee extension strength and 6MW distances. Conclusion Neuromuscular impairments are prevalent in childhood ALL survivors and interfere with physical performance. Higher cumulative doses of vincristine and/or intrathecal methotrexate are associated with long-term neuromuscular impairments, which have implications on future function as these survivors age.

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Section: Introductionmentioning

confidence: 99%

Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia

Ness

Hudson

Pui

et al. 2011

Cancer

125

134

View full text Add to dashboard Cite

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Current awareness: Pharmacoepidemiology and drug safety

2009

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 23 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Antidiabetic Agents; 21 Contrast Agents; 22 Bone Conservation Agents; 23 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Nervous system viral infections in immunocompromised hosts

Pruitt

2014

Neurovirology

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Polyradiculopathy Due to Methotrexate-Induced Ebv-Associated Lymphoproliferative Disorder

Cited by 5 publications

References 7 publications

Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia

Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia

Current awareness: Pharmacoepidemiology and drug safety

Nervous system viral infections in immunocompromised hosts

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