Polypyrrole solid phase microextraction: A new approach to rapid sample preparation for the monitoring of antibiotic drugs

Szultka, Małgorzata; Kegler, Ricarda; Fuchs, Patricia; Olszowy, Pawel; Miekisch, Wolfram; Schubert, Jochen K.; Buszewski, Bogusław; Mundkowski, Ralf G.

doi:10.1016/j.aca.2010.04.011

Cited by 45 publications

(25 citation statements)

References 20 publications

(25 reference statements)

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“…Based on the preparation protocol, the fibers were reported with thicknesses ranging from dozens to hundreds micrometers and often possessed rather rough and granulated morphologies. To date, various analytes including organochlorine pesticides [191], phenols [192], phthalate esters [193], antibiotic drugs [194][195][196], and adrenolytic drugs [197], have been analyzed in different sample matrices, even in human plasma [195][196][197] and whole blood [194]. It is notable that Olszowy et al [196] have used several different poly(3-alkylthiophene)-coated SPME fibers to extract linezolid, which showed that the functional groups on the monomeric units could affect the EEs.…”

Section: Conductive Polymers and Modified Silicamentioning

confidence: 98%

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Development of Novel Solid-Phase Microextraction Fibers

Xu¹,

Ouyang²

2016

Solid Phase Microextraction

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The basic principles for the preparation of SPME fibers with satisfying selectivity, sensitivity, loading capacities and stabilities are summarized here in terms of the physicochemical properties of the coating materials and the supporting substrates of SPME fibers. While the main part of this chapter focuses on the advances in developing the most widely used coating materials, including ionic liquids, polymeric ionic liquids, carbonaceous materials, molecularly imprinted polymers, metal-organic frameworks, metals and metal oxides, conductive polymers, modified silica, as well as their composites, into SPME fibers. Meanwhile, the applications of novel SPME fibers in analyzing diverse analytes in different sample matrices are briefly reviewed, including the emerging applications of SPME in the extraction of bioactive compounds in living animals and plants.Keywords SPME fiber coating Á Ionic liquid Á Polymeric ionic liquid Á Graphene Á Carbon nanotube Á Molecularly imprinted polymer Á Metal-organic framework Á Metal and metal oxide Á Conductive polymer Á Modified silica IntroductionThe outstanding features of solid-phase microextraction (SPME), including rapid and simple operating procedures, slight disturbance to investigated systems, reduced consumption of solvents, and feasibility of automation, continuously inspire new explorations of SPME in various frontiers, such as metabolome detection [1], central nervous systems studies [2], pharmacokinetic studies [3], environmental analysis [4], and food analysis [5]. On the other hand, the diversity of the physicochemical properties of the target analytes and the complicity of the sample matrices require the development of new SPME devices to nourish the new

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Section: Conductive Polymers and Modified Silicamentioning

confidence: 98%

“…RAMs were also used as SPME fiber coatings for extracting pharmaceuticals in whole blood [203]. In addition, as described in the last section, PPY-and PTH-coated fibers were also used to detect drugs in human plasma and whole blood [194][195][196][197].…”

Section: Fibers For DI Spme In Biological Matricesmentioning

confidence: 99%

Development of Novel Solid-Phase Microextraction Fibers

Xu¹,

Ouyang²

2016

Solid Phase Microextraction

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“…Paper published to this time was focused basically on the creation of the polypyrrole coatings, robustness and short characterizations of the fibers [16]. However, investigations concerned possible interactions between polypyrrole surface and appropriate molecules and consideration about potential application of the fibers prepared on the electrochemical polymerization way as the porous adsorbent in solid-phase microextraction were also performed and published [17,18]. Current work mainly is focused on extraction of five adrenolytic drugs with different physicochemical properties and biomedical applications.…”

Section: Introductionmentioning

confidence: 98%

Fibers with polypyrrole and polythiophene phases for isolation and determination of adrenolytic drugs from human plasma by SPME-HPLC

Olszowy

Szultka

Ligor

et al. 2010

Journal of Chromatography B

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“…Up to this time, with the use of this technique adrenolytic drugs [12,13] and antibiotics applied in the bacterial infections treatment, transplantology and psychotropic drugs were analyzed. Using in vitro and in vivo methods analyses with standard deviations on a very low level were performed [14,15]. Beside commercially available SPME coatings, porous adsorbents prepared on the electrochemical polymerisation way have been recently applied as well.…”

Section: Introductionmentioning

confidence: 99%