Polypyrrole-Silicon Nanowire Arrays for Controlled Intracellular Cargo Delivery

Loh, Daniel M.; Nava, Matthew; Nocera, Daniel G.

doi:10.1021/acs.nanolett.1c04033

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…To achieve the intracellular delivery, the PPy film was coated on silicon nanowire arrays. [152] Under the voltage-controlled process, PPy can efficiently transport nucleic acids, small molecule drugs, and other therapeutics inside the cell membrane. To increase the drug loading and lengthen the release time, Bansal et al reported a PPy hydrogel that can accommodate more glutamate for glutamate delivery.…”

Section: Drug Deliverymentioning

confidence: 99%

Bioelectronic Applications of Intrinsically Conductive Polymers

Gao

Bao

Chen

et al. 2023

Adv Elect Materials

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Since the discovery of conducting polyacetylene in the 1970s, intrinsically conducting polymers (ICPs) have attracted great attention because of their interesting structure, properties, and applications. Notably different from conventional conductors such as metals and doped semiconductors, ICPs have high mechanical flexibility and are light weight. In addition, their properties can be easily tuned by controlling the doping level, modifying the chemical structure, or forming composites with organic or inorganic materials. Their application in bioelectronics is particularly interesting because they have good biocompatibility and good mechanical matching with biological tissues. In this article, the methods to increase the mechanical stretchability of ICPs are first reviewed because high stretchability is often required for bioelectronic applications while pristine ICPs generally have limited stretchability. The application of ICPs as stretchable electrodes for epidermal biopotential detection and neural interfaces is discussed. Then, the employment of ICPs as the electrodes or sensing material of mechanical sensors is reviewed. They also have important application in controllable drug delivery. Last, their applications in the wearable energy harvesting and storage devices including thermoelectric generators and supercapacitors are also covered.

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Section: Drug Deliverymentioning

confidence: 99%

Bioelectronic Applications of Intrinsically Conductive Polymers

Gao

Bao

Chen

et al. 2023

Adv Elect Materials

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“…Shalek et al 24 developed a surface‐modified vertical SiNWA to deliver biomolecules into immortalized and primary mammalian cells. Loh et al 25 designed a conductive polypyrrole (PPy)‐SiNWA device for intracellular delivery of nucleic acids, small molecule drugs, and other therapeutics. Owing to their nanotopographical and chemical properties, SiNWAs also can influence the behavior of cells, such as the proliferation, viability, and differentiation 26 .…”

Section: Introductionmentioning

confidence: 99%

Silicon nanowire array overcomes chemotherapeutic resistance by inducing the differentiation of breast cancer stem cells

Wang

Liu²,

Zhang

et al. 2023

J Biomed Mater Res

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Currently, traditional cancer treatment strategies are greatly challenged by the existence of cancer stem cells (CSCs), which are root cause of chemotherapy resistance.Differentiation therapy presents a novel therapeutic strategy for CSC-targeted therapy. However, there are very few studies on the induction of CSCs differentiation so far. Silicon nanowire array (SiNWA) with many unique properties is considered to be an excellent material for various applications ranging from biotechnology to biomedical applications. In this study, we report the SiNWA differentiates MCF-7-derived breast CSCs (BCSCs) into non-CSCs by modulating the morphology of cells. In vitro, the differentiated BCSCs lose the stemness properties and thus become sensitive to chemotherapeutic drugs, eventually leading to the death of BCSCs. Therefore, this work suggests a potential approach for overcoming chemotherapeutic resistance.

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Controllable Fabrication of Polypyrrole Nanopillar/Hair Arrays by Oxygen Plasma Treatment and Their Applications as Antibacterial Flexible pH Sensors

Shang,

Chen,

Ling

et al. 2024

Adv Materials Technologies

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Flexible pH sensors have attracted a great deal of attention in numerous applications, such as wearable healthcare devices, smart wound bandages, and other pH monitor sensors for chemical and bioprocess control. Herein, a facile approach to fabricate conducting polymer polypyrrole nanopillar arrays is proposed, and its potential as an advanced pH sensing interface is shown. Using oxygen plasma treatment as the etching tool, polypyrrole nanopillar/hair arrays can be prepared after etching 3D polypyrrole network structures. Conductive polypyrrole nanopillar arrays possessed unique advantages in sensing: their featured nanopillars has enhanced antibacterial properties; their structures showed excellent hydrophilicity and are favorable for interaction with analytes in small‐volume liquids. A flexible polypyrrole nanopillar array‐based potentiometric pH sensor integrated with a solid‐state reference electrode is further designed and fabricated. Superior performance with a near‐Nernstian response of 60.1±1.0 mV pH−1, excellent repeatability, high stability, and reproducibility is verified in the physiological pH range. The reliabilities of flexible and small‐volume sample testing, as well as the applicability for artificial sweat sample pH sensing, are examined. Provided with the advantages of antibacterial properties and hydrophilicity, the proposed flexible pH sensor is promising for trace analysis in biological, medical, and healthcare applications.

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Polypyrrole-Silicon Nanowire Arrays for Controlled Intracellular Cargo Delivery

Cited by 5 publications

References 28 publications

Bioelectronic Applications of Intrinsically Conductive Polymers

Bioelectronic Applications of Intrinsically Conductive Polymers

Silicon nanowire array overcomes chemotherapeutic resistance by inducing the differentiation of breast cancer stem cells

Controllable Fabrication of Polypyrrole Nanopillar/Hair Arrays by Oxygen Plasma Treatment and Their Applications as Antibacterial Flexible pH Sensors

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