Polypyrrole nanotube modified by gold nanoparticles for improving the neural microelectrodes

Kojabad, Zohreh Deljoo; Shojaosadati, Seyed Abbas; Firoozabadi, Seyed Mohammad; Hamedi, Sepideh

doi:10.1007/s10008-019-04245-1

Cited by 11 publications

(8 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 195 , 196 , 197 ] In particular, electrochemical oxidation of pyrrole monomers is the most diffuse approach to deposit PPy films on the surface of neural probe microelectrodes. [ 197 , 198 ] PPy/MWCNTs composites were developed by Baranauskas and co. to improve the recording performance of PPy‐based electrodes. [ 199 ] Low impedance PPy/MWCNTs electrodes were implanted in the vibrissa region of rat somatosensory cortex and allowed to record single unit activity, LFPs and multi‐unit activity with an up to fourfold SNR compared to uncoated microelectrodes.…”

Section: Extracellular Recording With Neural Devices Based On Pedot:x...mentioning

confidence: 99%

Poly(3,4‐ethylenedioxythiophene)‐Based Neural Interfaces for Recording and Stimulation: Fundamental Aspects and In Vivo Applications

et al. 2022

View full text Add to dashboard Cite

Next‐generation neural interfaces for bidirectional communication with the central nervous system aim to achieve the intimate integration with the neural tissue with minimal neuroinflammatory response, high spatio‐temporal resolution, very high sensitivity, and readout stability. The design and manufacturing of devices for low power/low noise neural recording and safe and energy‐efficient stimulation that are, at the same time, conformable to the brain, with matched mechanical properties and biocompatibility, is a convergence area of research where neuroscientists, materials scientists, and nanotechnologists operate synergically. The biotic–abiotic neural interface, however, remains a formidable challenge that prompts for new materials platforms and innovation in device layouts. Conductive polymers (CP) are attractive materials to be interfaced with the neural tissue and to be used as sensing/stimulating electrodes because of their mixed ionic‐electronic conductivity, their low contact impedance, high charge storage capacitance, chemical versatility, and biocompatibility. This manuscript reviews the state‐of‐the‐art of poly(3,4‐ethylenedioxythiophene)‐based neural interfaces for extracellular recording and stimulation, focusing on those technological approaches that are successfully demonstrated in vivo. The aim is to highlight the most reliable and ready‐for‐clinical‐use solutions, in terms of materials technology and recording performance, other than spot major limitations and identify future trends in this field.

show abstract

Section: Extracellular Recording With Neural Devices Based On Pedot:x...mentioning

confidence: 99%

Poly(3,4‐ethylenedioxythiophene)‐Based Neural Interfaces for Recording and Stimulation: Fundamental Aspects and In Vivo Applications

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Besides PEDOT, several other CPs, such as PPy, poly(aniline) (PANi), poly(thiophene) (PT), and some of their derivatives (Juarez-Hernandez et al, 2016 ; Kojabad et al, 2019 ; Nagane et al, 2020 ) are also alternative candidates. PPy has outstanding water solubility (Kojabad et al, 2019 ), 40–200 S/cm conductivity (Guimard et al, 2007 ), low Yong's moduli of 0.35 psi for thin films (15–35 μm thick) (Diaz and Hall, 1983 ), and 430–800 MPa for nanocomposites (Sevil and Zuhal, 2010 ). PPy can be electrodeposited in situ on the electrode surface with different dopants.…”

Section: Electrode Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

To date, a wide variety of neural tissue implants have been developed for neurophysiology recording from living tissues. An ideal neural implant should minimize the damage to the tissue and perform reliably and accurately for long periods of time. Therefore, the materials utilized to fabricate the neural recording implants become a critical factor. The materials of these devices could be classified into two broad categories: electrode materials as well as packaging and substrate materials. In this review, inorganic (metals and semiconductors), organic (conducting polymers), and carbon-based (graphene and carbon nanostructures) electrode materials are reviewed individually in terms of various neural recording devices that are reported in recent years. Properties of these materials, including electrical properties, mechanical properties, stability, biodegradability/bioresorbability, biocompatibility, and optical properties, and their critical importance to neural recording quality and device capabilities, are discussed. For the packaging and substrate materials, different material properties are desired for the chronic implantation of devices in the complex environment of the body, such as biocompatibility and moisture and gas hermeticity. This review summarizes common solid and soft packaging materials used in a variety of neural interface electrode designs, as well as their packaging performances. Besides, several biopolymers typically applied over the electrode package to reinforce the mechanical rigidity of devices during insertion, or to reduce the immune response and inflammation at the device-tissue interfaces are highlighted. Finally, a benchmark analysis of the discussed materials and an outlook of the future research trends are concluded.

show abstract

“…It should also be noted that nanomaterial and nanostructure modifications to the MEA surface have a significant impact on their electrical conductivity when electroconductive materials are used. In a study by Kojabad et al, MEAs were enhanced with nanostructural modifications by coating them with polypyrrol nanotubes augmented with gold nanoparticles, which led to a tenfold decrease in the electrochemical impedance compared to the uncoated control. Burblies et al coated platinum cochlear neural electrodes with carbon nanotubules (CNTs).…”

Section: Microelectrode Array Modifications For Improving the Neural mentioning

confidence: 99%

A Critical Review of Microelectrode Arrays and Strategies for Improving Neural Interfaces

Ferguson

Sharma

Ross

et al. 2019

Adv Healthcare Materials

View full text Add to dashboard Cite

Though neural interface systems (NISs) can provide a potential solution for mitigating the effects of limb loss and central nervous system damage, the microelectrode array (MEA) component of NISs remains a significant limiting factor to their widespread clinical applications. Several strategies can be applied to MEA designs to increase their biocompatibility. Herein, an overview of NISs and their applications is provided, along with a detailed discussion of strategies for alleviating the foreign body response (FBR) and abnormalities seen at the interface of MEAs and the brain tissue following MEA implantation. Various surface modifications, including natural/synthetic surface coatings, hydrogels, and topography alterations, have shown to be highly successful in improving neural cell adhesion, reducing gliosis, and increasing MEA longevity. Different MEA surface geometries, such as those seen in the Utah and Michigan arrays, can help alleviate the resultant FBR by reducing insertion damage, while providing new avenues for improving MEA recording performance and resolution. Increasing overall flexibility of MEAs as well as reducing their stiffness is also shown to reduce MEA induced micromotion along with FBR severity. By combining multiple different properties into a single MEA, the severity and duration of an FBR postimplantation can be reduced substantially.

show abstract

Polypyrrole nanotube modified by gold nanoparticles for improving the neural microelectrodes

Cited by 11 publications

References 32 publications

Poly(3,4‐ethylenedioxythiophene)‐Based Neural Interfaces for Recording and Stimulation: Fundamental Aspects and In Vivo Applications

Poly(3,4‐ethylenedioxythiophene)‐Based Neural Interfaces for Recording and Stimulation: Fundamental Aspects and In Vivo Applications

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

A Critical Review of Microelectrode Arrays and Strategies for Improving Neural Interfaces

Contact Info

Product

Resources

About