Polypyrrole-coated poly(l-lactic acid-co-ε-caprolactone)/silk fibroin nanofibrous nerve guidance conduit induced nerve regeneration in rat

Sun, Binbin; Zhou, Zifei; Li, Dawei; Wu, Tong; Zheng, Hao; Liu, Junjian; Wang, Gangyang; Yu, Yinxian

doi:10.1016/j.msec.2018.09.021

Cited by 74 publications

(49 citation statements)

References 23 publications

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“…Following this success, 10‐mm defects in rat sciatic nerves were treated with the PPy/PDLLA scaffolds, in comparison to pristine PDLLA and gold standard autografts. Similar to Sun et al, at both 3 and 6 months, minimally doped 5% PPy (conductivity = 5.6 mS cm −1 ) scaffold matches autograft in a host of recovery metrics: sciatic function index triceps weight recovery, nerve conduction velocity, axon diameter, nerve fiber diameter and myelin sheath thickness and density. PDLLA scaffold without PPy was inferior in all in vivo metrics.…”

Section: Conductive Scaffolds For Neuronal Tissue Engineeringsupporting

confidence: 54%

“…These facts demonstrate the necessity of the conductive element in the system to augment neuronal cell development via electrical stimulation. Further emphasizing the promise of conductive polymers for peripheral nerve treatment, Sun et al performed follow up experiments to their 2016 study by using their PLCL/SF/PPy scaffold in vivo . Results of rat sciatic nerve treatment showed matching results with the gold standard autograft in most metrics, save for slightly diminished axonal diameter and myelin thickness, in which the nondoped control paled in comparison.…”

Section: Conductive Scaffolds For Neuronal Tissue Engineeringmentioning

confidence: 99%

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Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

103

102

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Tissue engineering is a promising therapeutic approach in medicine, targeting the replacement of a diseased tissue with a healthy one grown within an artificial scaffold. Due to the high prevalence of cardiac and brain‐related ailments that involve some necrosis of tissue, cardiac and neuronal tissue engineering are intensely studied fields in regenerative medicine. A growing trend in the use of conductive scaffolds for the growth of these tissues has been witnessed recently. While the results are irrefutable, the mechanism of how an electrically conducting scaffold interacts with an electroactive tissue remains has remained elusive. An up‐to‐date summary of all work done in the field is reported, with a special focus on the specific contribution of the conductive scaffold on the performance of the formed tissue. The cell–scaffold electronic interface is then explored from an electrical engineering perspective. The electronic configuration of the system and the mechanisms and governing factors controlling the ability of a conductive scaffold to support cardiac and neuronal tissues are discussed. Using several simulations, the required conductivity of the scaffold in order for it to be suitable for tissue engineering—which also depends on the nature of the charge carriers—is also discussed.

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Section: Conductive Scaffolds For Neuronal Tissue Engineeringsupporting

confidence: 54%

Section: Conductive Scaffolds For Neuronal Tissue Engineeringmentioning

confidence: 99%

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

103

102

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“…32 In agreement with this, Sun et al claimed that the presence of polypyrrole (Ppy) within a nerve guide would stimulate Schwann cell proliferation in early post-surgery and enhance myelin formation in later post-surgery. 33 Similarly, Feng et al reported the positive contribution of electric elds on the guided migration of neural stem cells, including their strong impact on functional recovery. 34 A direct current electric eld was highlighted as a cue to guide neurite growth and the migration of neurons and other types of cells.…”

Section: Introductionmentioning

confidence: 96%

Three-dimensional directional nerve guide conduits fabricated by dopamine-functionalized conductive carbon nanofibre-based nanocomposite ink printing

et al. 2020

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“…[ 11 ] Recently, regeneration of nerve tissue has been successfully achieved by PLCL combined with bioactive molecules such as gelatin, silk fibroin, extracellular matrix (ECM) proteins, growth factors, peptides, and neurotrophic drugs. [ 10–12 ]…”

Section: Introductionmentioning

confidence: 99%

Methylcobalamin‐Loaded PLCL Conduits Facilitate the Peripheral Nerve Regeneration

Zhang

Yang

Wang

et al. 2020

Macromolecular Bioscience

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The feasible fabrication of nerve guidance conduits (NGCs) with good biological performance is important for translation in clinics. In this study, poly(d,l‐lactide‐co‐caprolactone) (PLCL) films loaded with various amounts (wt; 5%, 15%, 25%) of methylcobalamin (MeCbl) are prepared, and are further rolled and sutured to obtain MeCbl‐loaded NGCs. The MeCbl can be released in a sustainable manner up to 21 days. The proliferation and elongation of Schwann cells, and the proliferation of Neuro2a cells are enhanced on these MeCbl‐loaded films. The MeCbl‐loaded NGCs are implanted into rats to induce the regeneration of 10 mm amputated sciatic nerve defects, showing the ability to facilitate the recovery of motor and sensory function, and to promote myelination in peripheral nerve regeneration. In particular, the 15% MeCbl‐loaded PLCL conduit exhibits the most satisfactory recovery of sciatic nerves in rats with the largest diameter and thickest myelinated fibers.

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Polypyrrole-coated poly(l-lactic acid-co-ε-caprolactone)/silk fibroin nanofibrous nerve guidance conduit induced nerve regeneration in rat

Cited by 74 publications

References 23 publications

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Three-dimensional directional nerve guide conduits fabricated by dopamine-functionalized conductive carbon nanofibre-based nanocomposite ink printing

Methylcobalamin‐Loaded PLCL Conduits Facilitate the Peripheral Nerve Regeneration

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