“…These proteins, including the SR proteins, many of the original hnRNP proteins (notably A1, H, L), the CELF, Nova, Rbfox, and Muscle blind families, and others, belong to a variety of structural families and have different RNA recognition properties and different patterns of expression in tissues (Graveley, 2000; Dreyfuss et al, 2002; Black, 2003; Chen and Manley, 2009; Kalsotra and Cooper, 2011). In addition to their nuclear role in RNA processing, these proteins, including PTB, also often affect cytoplasmic processes such as mRNA localization, translation or decay (Hellen et al, 1993; Cote et al, 1999; Kim et al, 2000; Tillmar and Welsh, 2002; Hamilton et al, 2003; de Hoog et al, 2004; Bushell et al, 2006; Fred et al, 2006; Sawicka et al, 2008; Babic et al, 2009; Besse et al, 2009; Kafasla et al, 2009; Cobbold et al, 2010; Matus-Nicodemos et al, 2011). Within the nucleus, these proteins affect large programs of alternative processing events (Ule et al, 2006; Boutz et al, 2007b; Kalsotra et al, 2008; Licatalosi et al, 2008; Xue et al, 2009; Yeo et al, 2009; Kalsotra and Cooper, 2011).…”