Polypropylene-nanodiamond composite for hernia mesh

Houshyar, Shadi; Sarker, Avik; Jadhav, Amit; Kumar, G. Sathish; Bhattacharyya, Amitava; Nayak, Rajkishore; Shanks, Robert A.; Saha, Tanushree; Rifai, Aaqil; Padhye, Rajiv; Fox, Kate

doi:10.1016/j.msec.2020.110780

Cited by 32 publications

(38 citation statements)

References 43 publications

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“…One of the studies done by Houshyar et al reported melt mixing fabrication of a ND‐polypropylene fibre composite for surgical mesh application. The results showed there was a significant enhancement in mechanical strength and reduction in tissue adhesion of the modified ND‐polypropylene mesh (Houshyar et al, 2020). Another study was done by Ruan et al on the application of ND‐glass fibres for sensing applications (Ruan et al, 2018).…”

Section: Fabrication and Application Of Different Diamond Surfaces Fomentioning

confidence: 99%

“…The reinforced polymeric materials with ND, ND-composites, are usually in the form of thin films (Kalbacova et al, 2009;Kromka et al, 2010;Nistor & May, 2017a), or microfilaments and electrospun nanofibrous scaffolds (Houshyar et al, 2019;Mahdavi et al, 2016). Both forms of ND-composite have shown enhancement in mechanical properties and effectively support cell adhesion and growth (Ahn et al, 2018;Houshyar et al, 2019Houshyar et al, , 2020Nistor & May, 2017a). ND-loaded nanofibrous scaffolds also show improved growth and adhesion of cells when compared to thin films, as the cells are highly sensitive to the physical properties of the underlying scaffold (Kromka et al, 2010;Nistor & May, 2017a (Gao et al, 2019).…”

Section: Electrospinning and Melt Processing Of Nanodiamond Compositesmentioning

confidence: 99%

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Diamond in medical devices and sensors: An overview of diamond surfaces

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The human body is a sophisticated environment for research. There has been progress in developing advanced medical devices and sensors to contribute to recovery and therapy. However, as the field progresses new materials with specific properties are required to maximize recovery and therapy efficiency. Desired properties include materials that can contribute to cell regeneration and proliferation while preventing bacterial biofilm formation. Additionally, the variability in geometries of diseased parts requires improvement in processing to provide case and geometry-specific solutions (Raghavendra et al., 2015). Hence, there is a need for novel biomaterials that better match the native tissue. Their effectiveness and functionality are crucial to the long-term physical activity and health of patients. Carbon-based materials have attracted attention due to their unique characteristics, including mechanical, thermal and optical properties (Martel-Estrada, 2018), and they have been used in the

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Section: Fabrication and Application Of Different Diamond Surfaces Fomentioning

confidence: 99%

Section: Electrospinning and Melt Processing Of Nanodiamond Compositesmentioning

confidence: 99%

Diamond in medical devices and sensors: An overview of diamond surfaces

et al. 2020

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“…In the case of NDs, many studies concluded that no cytotoxicity had been found [ 181 , 182 , 183 ]. In an extensive study, no ROS generation was found.…”

Section: Carbon-based Nanomaterialsmentioning

confidence: 99%

Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration

et al. 2020

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Bone possesses an inherent capacity to fix itself. However, when a defect larger than a critical size appears, external solutions must be applied. Traditionally, an autograft has been the most used solution in these situations. However, it presents some issues such as donor-site morbidity. In this context, porous biodegradable scaffolds have emerged as an interesting solution. They act as external support for cell growth and degrade when the defect is repaired. For an adequate performance, these scaffolds must meet specific requirements: biocompatibility, interconnected porosity, mechanical properties and biodegradability. To obtain the required porosity, many methods have conventionally been used (e.g., electrospinning, freeze-drying and salt-leaching). However, from the development of additive manufacturing methods a promising solution for this application has been proposed since such methods allow the complete customisation and control of scaffold geometry and porosity. Furthermore, carbon-based nanomaterials present the potential to impart osteoconductivity and antimicrobial properties and reinforce the matrix from a mechanical perspective. These properties make them ideal for use as nanomaterials to improve the properties and performance of scaffolds for bone tissue engineering. This work explores the potential research opportunities and challenges of 3D printed biodegradable composite-based scaffolds containing carbon-based nanomaterials for bone tissue engineering applications.

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“…Detonation nanodiamonds (NDs) are gaining significant interest for their mechanical strength, optical properties, and biocompatibility [1][2][3][4]. NDs have been assessed for biocompatibility both in vitro and in vivo with positive outcomes such as low cytotoxicity [5][6][7], improved cellular adhesion [8], and improved cell proliferation [3]. They are significantly less cytotoxic than other carbon-based nanoparticles such as CNTs [7], and endocytic NDs are non-cytotoxic during cell division and differentiation [9].…”

Section: Introductionmentioning

confidence: 99%

High Nanodiamond Content-PCL Composite for Tissue Engineering Scaffolds

et al. 2020

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Multifunctional scaffolds are becoming increasingly important in the field of tissue engineering. In this research, a composite material is developed using polycaprolactone (PCL) and detonation nanodiamond (ND) to take advantage of the unique properties of ND and the biodegradability of PCL polymer. Different ND loading concentrations are investigated, and the physicochemical properties of the composites are characterized. ND-PCL composite films show a higher surface roughness and hydrophilicity than PCL alone, with a slight decrease in tensile strength and a significant increase in degradation. Higher loading of ND also shows a higher osteoblast adhesion than the PCL alone sample. Finally, we show that the ND-PCL composites are successfully extruded to create a 3D scaffold demonstrating their potential as a composite material for tissue regeneration.

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Polypropylene-nanodiamond composite for hernia mesh

Cited by 32 publications

References 43 publications

Diamond in medical devices and sensors: An overview of diamond surfaces

Diamond in medical devices and sensors: An overview of diamond surfaces

Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration

High Nanodiamond Content-PCL Composite for Tissue Engineering Scaffolds

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