Polypropylene mesh covered colonic anastomosis. Results of a new anastomosis technique

Ayşan, Erhan; Dinçel, Oğuzhan; Bektaş, Hasan; Alkan, Murat

doi:10.1016/j.ijsu.2008.04.001

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…These results suggest that when an intraluminal pressure is exerted to the colonic wall, anastomosis that is reinforced by ASC sheet is less susceptible to perforation. Alternative techniques that have been used previously in an attempt to prevent leakage of gastrointestinal anastomosis have been based on the sealing of the anastomosis with tissue adhesives or synthetic meshes [26,27]. Although these techniques for leakage prevention have various levels of clinical efficacy, they are imperfect solutions that can give burdens for patients.…”

Section: █ Discussionmentioning

confidence: 99%

Effects of adipose stem cell sheets on colon anastomotic leakage in an experimental model: Proof of principle

et al. 2017

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The most dreaded complication of colorectal surgery is anastomotic leakage. Adipose tissue-derived stem cell sheets (ASC sheets) prepared from temperature-responsive culture surfaces can be easily transplanted onto tissues. These sheets are proposed to improve cell transplant efficiency and enhance wound healing. The aim of this study was to investigate whether application of ASC sheets could prevent leakage of sutured colorectal anastomoses. Insufficient suturing of colorectal anastomoses was performed in Wistar rats to create a colorectal anastomotic leakage model. Rats were randomized to ASC sheet application or control group. Leakage, abscess formation, adhesion formation, anastomotic bursting pressure (ABP), and histology were evaluated on postoperative day 3 or 7. ASC sheet application significantly reduced anastomotic leakage compared to controls, without increased adhesion formation. ASC sheet transplantation resulted in more CD3+ T-cells and CD163+ anti-inflammatory macrophages at the anastomotic site than the control group. ABP, vessel density and collagen deposition were not different between groups. Using cell sheet technology, we generated ASC sheets that prevented disruption of sutured colorectal anastomoses as shown by reduced leakage. Increased numbers of anti-inflammatory macrophages and T-cells might have contributed to this positive effect.

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Section: █ Discussionmentioning

confidence: 99%

Effects of adipose stem cell sheets on colon anastomotic leakage in an experimental model: Proof of principle

et al. 2017

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“…Unfortunately, many of these attempts have failed to show convincing results [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48]. Numerous studies have reported on the sealing of gastrointestinal anastomoses with fibrin glue (FG), also called fibrin sealant.…”

Section: Introductionmentioning

confidence: 99%

Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

et al. 2014

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Background/Aim: Anastomotic leakage remains a frequent and serious complication in gastrointestinal surgery. In order to reduce its incidence, several clinical and experimental studies on anastomotic sealing have been performed. In a number of these studies, the sealing material has been fibrin glue (FG), and the results in individual studies have been varying. The positive effect of anastomotic sealing with FG might be due to the mechanical/physical properties, the increased healing of the anastomoses or both. The aim of this systematic review was to evaluate the existing evidence on the healing effects of FG on gastrointestinal anastomoses. Methods: PubMed, EMBASE and the Cochrane databases were searched for studies evaluating the healing process of gastrointestinal anastomoses after any kind of FG application. The search period was from 1953 to December 2013. Results: Twenty-eight studies were included in the qualitative synthesis. These studies were all experimental studies, since no human studies used histological or biochemical evaluation of healing. In 7 of the 28 studies, a positive effect of FG on healing was found, while 8 studies reported a negative effect and 11 studies found no effect. Furthermore, 2 studies reported unclear results. The difference in the study outcome was independent of the study design and the type of FG used. Conclusion: In the available studies, FG did not consistently have a positive influence on the healing of gastrointestinal anastomoses. It is consequently plausible that the positive effect of FG sealing of gastrointestinal anastomoses, if there is any, may be due to a mechanical sealing effect rather than due to improved healing per se.

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External coating of colonic anastomoses: a systematic review

Pommergaard

Achiam

Rosenberg

2012

Int J Colorectal Dis

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Polypropylene mesh covered colonic anastomosis. Results of a new anastomosis technique

Abstract: During the short follow-up period, this new technique significantly increased the safety of the anastomosis, moreover it did not cause any increase in peritoneal adhesions. This success has most probably occurred as a result of the external mechanical support to the anastomosis.

Cited by 7 publications

References 27 publications

Effects of adipose stem cell sheets on colon anastomotic leakage in an experimental model: Proof of principle

Effects of adipose stem cell sheets on colon anastomotic leakage in an experimental model: Proof of principle

Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

External coating of colonic anastomoses: a systematic review

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