Polypropylene grafted with smart polymers (PNIPAAm/PAAc) for loading and controlled release of vancomycin

Hernia-repair prosthetic devices functionalised with chitosan and ciprofloxacin coating: controlled release and antibacterial activity

“…12 Only few authors suggest the application of preventive treatment of the meshes with broad-spectrum antibiotics. [13][14][15][16] Recently, an interesting study has been realised by Fernandez-Gutierrez et al:…”

Nanostructures and Nanostructured Networks for Smart Drug Delivery

“…Similarly, the graft polymerization of 1-vinylimidazole and of acrylonitrile onto polypropylene monofilaments rendered sutures that can elute ciprofloxacin or tetracycline hydrochloride in a sustained way under in vivo conditions [281,282]. Monomers suitable for endowing polypropylene and polyethylene substrates with affinity for vancomycin were screened using isothermal titration calorimetry in order to establish a rational surface functionalization protocol [283]. Acrylic acid sodium salt was identified as suitable for interacting with the drug.…”

“…Then, interpenetrated networks of poly(acrylic acid) and PNIPAAm were prepared by grafting to the substrate one of the networks followed by polymerization/cross-linking of the second network [284]. The resultant functionalized surfaces were dually pH and temperature responsive (Figure 18.20), exhibited a synergistic loading mechanism, and were able to release vancomycin at a rate suitable to prevent in vitro the formation of methicillin-resistant Staphylococcus aureus (MRSA) biofilms [283,285].…”

Stimuli–responsive networks grafted onto polypropylene for the sustained delivery of NSAIDs

“…Surface functionalization with stimulus-responsiveness is being evaluated for the preparation of drug eluting medical devices, with promising results. The bioactive compounds can chemically interact through reversible bonds with the modified surfaces, becoming trapped in a three-dimensional polymer network from which they can be released in a controlled way by certain physiological variables, such temperature or pH [21,22].…”