Polypropylene Graft Poly(methyl methacrylate) Graft Poly(N-vinylimidazole) as a Smart Material for pH-Controlled Drug Delivery

Abstract

Surface modification of polypropylene (PP) films was achieved using gamma-irradiation-induced grafting to provide an adequate surface capable of carrying glycopeptide antibiotics. The copolymer was obtained following a versatile two-step route; pristine PP was exposed to gamma rays and grafted with methyl methacrylate (MMA), and afterward, the film was grafted with N-vinylimidazole (NVI) by simultaneous irradiation. Characterization included Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and physicochemical analysis of swelling and contact angle. The new material (PP-g-MMA)-g-NVI was loaded with vancomycin to quantify the release by UV-vis spectrophotometry at different pH. The surface of (PP-g-MMA)-g-NVI exhibited pH-responsiveness and moderate hydrophilicity, which are suitable properties for controlled drug release.

Lignocellulosic membrane grafted with 4-vinylpiridine using radiation chemistry: antimicrobial activity of loaded vancomycin

“…Poly(4VP) (here abbreviated as P4VP) is considered a safe material and exhibits a characteristic that allows modification of its pH responsiveness by controlling the molecular weight using polymer concentrations and copolymer composition (López-Saucedo et al 2022). Therefore, grafting of 4VP onto lignocellulosic films should endow with a pH response enhancing controlled drug delivery to the treatment site, providing a potential application as an antimicrobial drug-releasing wound dressing (Kiziltas et al 2014(Kiziltas et al , 2016Shrestha et al 2016).…”

Synthesis of Crosslinked Microparticles Based on Glycidyl Methacrylate and N‐Vinylimidazole

“…This vinyl monomer was previously used in enzyme immobilization, [21] water treatment, [22,23] catalysis, [24] and drug delivery systems. [25][26][27] Suspension, precipitation, and emulsification polymerization are the most widely adopted methods to prepare porous microparticles and for this study suspension polymerization was chosen because it presents a number of economic and technical advantages. [28][29][30] The success of the preparation of suitable porous microparticles by suspension polymerization is ensured by the appropriate choice of operational parameters.…”

“…This vinyl monomer was previously used in enzyme immobilization, [ 21 ] water treatment, [ 22,23 ] catalysis, [ 24 ] and drug delivery systems. [ 25–27 ]…”