POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1

Пронин, А В; Ожерелков, С. В.; Deeva, A V; Санин, А. В.; Наровлянский, А. Н.

doi:10.15789/2220-7619-2012-3-645-650

Cited by 4 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, FP is still successfully used as a means of etiotropic therapy and as part of a comprehensive treatment regimen for certain cases of viral infections, for example, canine distemper (Glazunov and Kornev, 2016), parvoviral enteritis (Petrakova, 2018;Koshlyak and Kankalov, 2022), "aviary cough" syndrome (Usikova and Rachikhina, 2019), and outbreaks of diseases in nurseries (Dmytry-shyn, 2012;Savoyskaya and Kozhevnikova, 2019). In addition, FP is successfully used as an adjuvant for vaccines (Kozhevnikova et al, 2006), contributing to both an increase in the titer of specific antibodies and increasing the immunity strength (Pronin et al, 2011;Ozherelkov et al, 2012). Under experimental conditions, the adjuvant properties of FP were detected with combined use with tick-borne encephalitis, parvoviral enteritis, rabies (Ozherelkov et al, 2017b;Ozherelkov and Kozhevnikova, 2020), and hepatitis C vaccines (Onishchuk et al, 2017;Masalova et al, 2018).…”

Section: Ppf-based Drugs Usage In Prevention and Treatment Of The Vir...mentioning

confidence: 99%

“…The lipophilic prenyl group facilitates the consolidation of proteins in cell membranes, mediating protein-white interactions and signal transmission. This explains the extraordinary variety of physiological properties of polyprenols: they have immunomodulating (Pronin et al, 2002), adjuvant (Pronin et al, 2011), antioxidant (Sanin et al, 2017a), anti-inflammatory (Ganshina et al, 2011), and other important properties (Narovlyansky et al, 2018), which makes them attractive objects for the development of therapeutic remedies (Narovlyansky et al, 2007). The purpose of this article is to analyze the wealth of information about the antiviral activity of these unique compounds.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression

et al. 2022

View full text Add to dashboard Cite

This review is focused on polyprenyl phosphatis (PPFs) (phosphorilated polyprenols), a unique class of natural compounds with a wide spectrum of biological activity. The main emphasis is put on their antiviral properties that were studied in numerous in vitro and in vivo experiments. The results formed the basis for the development of new drugs containing PPFs as the active substance. These drugs, due to their high efficiency and harmlessness, are widely used in veterinary practice in the treatment of viral diseases of both small domestic and agricultural animals. Also, the world’s first PPF-based drug is registered in Russia, and it can be used as part of a comprehensive therapy of chronic recurrent genital infection caused by the herpes simplex virus.

show abstract

Section: Ppf-based Drugs Usage In Prevention and Treatment Of The Vir...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression

et al. 2022

View full text Add to dashboard Cite

show abstract

“…So, pronounced interferonogenic activity of polyprenyl phosphate per se and its potentiation of interferonogenic activity of some viruses in vitro were demonstrated (Ozherelkov et al 2007 ). Intramuscular injection of 20 μg of disodium polyprenyl phosphate (5 μl of 0.4 % solution of the phosphate in the same complex aqueous solvent diluted to 0.2 ml with water for injection) to BALB/c mice (intact or infected intraperitoneally with tick-borne encephalitis viruses) similarly increased the level of IFN in the blood serum of the animals (Pronin et al 2012 ).…”

Section: Antihypercholesterolemic and Antihyperlipidemic Action Of Pomentioning

confidence: 99%

Plant Polyisoprenoids and Control of Cholesterol Level

Пронин

Данилов

Narovlyansky

et al. 2013

Arch. Immunol. Ther. Exp.

View full text Add to dashboard Cite

The ability of plant polyisoprenoids (polyprenols and polyprenyl phosphates) to diminish the levels of serum cholesterol affecting its biosynthetic pathway are highlighted here. Possible mechanism of such process is discussed. It is also noted that polyisoprenoids can prevent toxic injuries of the liver and restore disturbed hepatic functions. The possibility of polyprenyl phosphates to reveal at the same time anti-inflammatory action suppressing lipoxygenase activity and lowering the levels of proinflammatory cytokines will be illustrated. Attention will be focused on the potential usefulness of plant polyisoprenoids in the course of prevention and treatment of hypercholesterolemia. High efficiency for combined use of polyprenyl phosphate and β-sitosterol, which leads to substantial enhancement of the ability to overcome hypercholesterolemia versus the individual constituents will be demonstrated.

show abstract

“…Following direct treatment with PPP, the viral envelope is prone to disintegrate. PPP also induces a calcium signal, NF-κB activation, production of type 1 and type 2 interferons and tumor necrosis factor α (Danilov et al 2002 ; Kuritz 2009 ; Pronin et al 2014b ). In addition, it is assumed that PPP directly inhibits the synthesis of prenols necessary for viral replication (Narovlyansky et al 2018 ), and its excess leads to the formation of dolichyl phosphates (an important product of human cells necessary for glycosylation of proteins and maintaining the structure of cell membranes).…”

Section: Introductionmentioning

confidence: 99%

New Approaches to the Prevention and Treatment of Viral Diseases

Пронин

Narovlyansky

Санин

2021

Arch. Immunol. Ther. Exp.

View full text Add to dashboard Cite

The review discusses a new approach to the prevention and treatment of viral infections based on the use of pine needles polyprenyl phosphate (PPP) and associated with the infringement of prenylation process—the attachment of farnesol or geranyl geraniol to the viral protein. Currently, prenylation has been detected in type 1 adenovirus, hepatitis C virus, several herpes viruses, influenza virus, HIV. However, this list is far from complete, given that prenylated proteins play an extremely important role in the activity of the virus. We assume that the interferon produced in response to PPP may suppress expression of the SREBP2 transcription factor. As a result, the mevalonic acid pathway is violated and, as a result, the formation of early polyprenols precursors (geraniol, geranyl geraniol, farnesol), which are necessary for the prenylation of viral proteins, is blocked and the formation of mature, virulent virus particles is broken. As a consequence, the maturation of viral particles is inhibited, and defective particles are formed. Polyprenol was extracted from greenery (pine, fir and spruce needles, mulberry leaves, etc.), purified by chromatography, phosphorylated and identified by HPLC and NMR. Obtained PPP was used as antiviral in some experimental models in vitro and in vivo. During numerous studies, it was found that PPP manifested versatile antiviral effects, both in vitro and in vivo. The maximum effect was observed with viruses in which the presence of prenylated proteins was established, namely influenza A virus, HIV-1, tick-borne encephalitis virus, hepatitis A and C viruses, herpes simplex viruses type 1 and 2, some coronavirus. The available data obtained both in the experimental conditions and during clinical trials allow us to regard PPPs as safe and effective medicine for prevention and treatment of viral diseases.

show abstract

POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1

Cited by 4 publications

References 9 publications

Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression

Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression

Plant Polyisoprenoids and Control of Cholesterol Level

New Approaches to the Prevention and Treatment of Viral Diseases

Contact Info

Product

Resources

About