Polyprenols in Ginkgo biloba; a review of their chemistry (synthesis of polyprenols and their derivatives), extraction, purification, and bioactivities

Boateng, Isaac Duah

doi:10.1016/j.foodchem.2023.136006

Cited by 12 publications

(4 citation statements)

References 76 publications

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“…Flavonoids refer to compounds that consist of two phenolic hydroxyl benzene rings connected by three central carbon atoms [ 40 , 41 ], which are widely found in the roots, stems, leaves, flowers, and fruits of various plants [ 42 ]. They are also identified and purified from many Chinese medicinal materials, such as pueraria, ginkgo biloba, and sea buckthorn [ 43 , 44 , 45 ]. Plenty of studies have shown that flavonoids are capable of inhibiting atherosclerosis and are regarded as potential anti-cancer, anti-viral, anti-inflammatory, and anti-oxidant components [ 46 , 47 , 48 , 49 , 50 ].…”

Section: Main Chemical Components Of Areca Nutmentioning

confidence: 99%

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Sun,

Yu,

et al. 2024

Nutrients

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Areca catechu L. is a widely cultivated tropical crop in Southeast Asia, and its fruit, areca nut, has been consumed as a traditional Chinese medicinal material for more than 10,000 years, although it has recently attracted widespread attention due to potential hazards. Areca nut holds a significant position in traditional medicine in many areas and ranks first among the four southern medicines in China. Numerous bioactive compounds have been identified in areca nuts, including alkaloids, polyphenols, polysaccharides, and fatty acids, which exhibit diverse bioactive functions, such as anti-bacterial, deworming, anti-viral, anti-oxidant, anti-inflammatory, and anti-tumor effects. Furthermore, they also display beneficial impacts targeting the nervous, digestive, and endocrine systems. This review summarizes the pharmacological functions and underlying mechanisms of the bioactive ingredients in areca nut. This helps to ascertain the beneficial components of areca nut, discover its medicinal potential, and guide the utilization of the areca nut.

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Section: Main Chemical Components Of Areca Nutmentioning

confidence: 99%

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Sun,

Yu,

et al. 2024

Nutrients

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“…Ginkgo leaves contain high levels of bioactive compounds, such as terpene trilactones, flavonoids, proanthocyanidins, alkylphenols, carboxylic acids, sterols, polyprenols, and so on [11]. However, most of the research and applications of ginkgo leaves have focused on terpene trilactones and flavonoids, and other active components have less been studied and utilized [12]. An untargeted LC-MS metabolomics analysis was performed on ginkgo leaves and seeds at two developmental stages, identifying 8146 known metabolites.…”

Section: Introductionmentioning

confidence: 99%

The Lipophilic Extract from Ginkgo biloba L. Leaves Promotes Glucose Uptake and Alleviates Palmitate-Induced Insulin Resistance in C2C12 Myotubes

Li,

Lv,

Liu

et al. 2024

Molecules

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Ginkgo biloba L. (ginkgo) is a widely used medicinal plant around the world. Its leaves, which have been used as a traditional Chinese medicine, are rich in various bioactive components. However, most of the research and applications of ginkgo leaves have focused on terpene trilactones and flavonol glycosides, thereby overlooking the other active components. In this study, a lipophilic extract (GL) was isolated from ginkgo leaves. This extract is abundant in lipids and lipid-like molecules. Then, its effect and potential mechanism on glucose uptake and insulin resistance in C2C12 myotubes were investigated. The results showed that GL significantly enhanced the translocation of GLUT4 to the plasma membrane, which subsequently promoted glucose uptake. Meanwhile, it increased the phosphorylation of AMP-activated protein kinase (AMPK) and its downstream targets. Both knockdown of AMPK with siRNA and inhibition with AMPK inhibitor compound C reversed these effects. Additionally, GL ameliorated palmitate-induced insulin resistance by enhancing insulin-stimulated glucose uptake, increasing the phosphorylation of protein kinase B (PKB/AKT), and restoring the translocation of GLUT4 from the cytoplasm to the membrane. However, pretreatment with compound C abolished these beneficial effects of GL. In conclusion, GL enhances basal glucose uptake in C2C12 myotubes and improves insulin sensitivity in palmitate-induced insulin resistant myotubes through the AMPK pathway.

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“…Так, известно, что полипренолы оказывают нейропротекторный [3,4], гепатопротекторный [5,6] и гиполипидемический [5,7] эффект. Кроме того, полипренолы обладают выраженной антиоксидантной [2,8,9] активностью. Возможны иные виды фармакологического действия [10][11][12].…”

Section: Introductionunclassified

Development and validation of the chromatography-mass spectrometry technique for polyprenols quantitative assessment

Popov,

Antipina,

Savintsev

et al. 2024

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. Polyprenols are known as a class of natural long-chain isoprenoid alcohols, which are natural bioregulators that directly participate in the synthesis of cell membrane glycoproteins. Their hepatoprotective activity is proven, as well other types of their pharmacological effects are known, which is the reason of significant interest in these substances as a promising medicinal product. It is non-trivial task to determine the sum of polyprenols in extracts as include design and implementation of accurate reproducible analytical methods, which will subsequently be used in standardization.Aim. Development and validation of the chromatographic-mass spectrometric technique for polyprenols identification and their quantitative assessment.Materials and methods. Chromatographic separation of polyprenols was performed by using an HPLC Agilent 1260 Infinity II (Agilent Technologies, США); with the mixture of methanol, n-hexane, propanol-2, and aqueous ammonium acetate solution as eluent in gradient mode. An AB Sciex QTrap® 3200MD (AB Sciex Pte. Ltd., Singapore) triple quadrupole mass spectrometer was used as a detector, with the registration of polyprenols adducts.Results and discussion. The conditions for chromatographic separation and detection of polyprenols were identified. The developed technique was validated for the following characteristics: specificity, limit of detection, limit of quantification, linearity, accuracy, precision, range of application, and stability.Conclusion. It was determined the content of polyprenols in the substance recieved from Ginkgo biloba L. and Picea abies L. The developed technique can be used in the future to assess the content of polyprenols in drug products or pharmaceutical substances.

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Polyprenols in Ginkgo biloba; a review of their chemistry (synthesis of polyprenols and their derivatives), extraction, purification, and bioactivities

Cited by 12 publications

References 76 publications

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

The Lipophilic Extract from Ginkgo biloba L. Leaves Promotes Glucose Uptake and Alleviates Palmitate-Induced Insulin Resistance in C2C12 Myotubes

Development and validation of the chromatography-mass spectrometry technique for polyprenols quantitative assessment

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