Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice

Motohashi, Hiroaki; Sukigara, Haruna; Tahara, Yu; Saito, Keisuke; Yamazaki, Mayu; Shiraishi, Takeshi; Kikuchi, Yoshihiro; Haraguchi, Atsushi; Shibata, Shigenobu

doi:10.1016/j.nutres.2017.05.001

Cited by 8 publications

(6 citation statements)

References 31 publications

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“…Polyporus (Zhulin) is used as a diuresis in the treatment edema, while Bupleuri radix (Chaihu) is used for chronic hepatitis. The Per2 Luc mice were used to screen their effects on the circadian clock, and Polyporus was more effective than Bupleuri radix in manipulating the peripheral circadian clock phaseshift, and in promoting time-of-day dependency in vitro as well as in vivo [63].…”

Section: Daysmentioning

confidence: 99%

Circadian Clock Gene Expression and Drug/Toxicant Interactions as Novel Targets of Chronopharmacology and Chronotoxicology

Liu¹,

Li²,

Xu³

et al. 2018

Circadian Rhythm - Cellular and Molecular Mechanisms

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Circadian rhythms are driven and maintained by circadian clock gene networks in both brain and peripheral organs. In the liver, circadian rhythms produce oscillation in drug Phase-I, Phase-II, and Phase-III (transporters) metabolism genes, which in turn would affect drug disposition and detoxication, resulting in diurnal variations of efficacy and toxicity when drugs are given at different times of the day. On the other hand, drugs and toxicants could affect circadian clock gene expression to produce biological effects leading to therapeutic or toxic outcomes. This chapter reviewed the relevant literature and a dozen of publications from our work, discussed the interactions of circadian clock genes with drugs and/or toxicants to better understand the importance of circadian clock gene expression as novel targets in Pharmacology and Toxicology.

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Section: Daysmentioning

confidence: 99%

Circadian Clock Gene Expression and Drug/Toxicant Interactions as Novel Targets of Chronopharmacology and Chronotoxicology

Liu¹,

Li²,

Xu³

et al. 2018

Circadian Rhythm - Cellular and Molecular Mechanisms

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“…Identifying new functions for existing drugs, known as the drug repositioning approach, is a popular and powerful approach, and crude drugs used in traditional Japanese Kampo medicine are major sources of new chemical entities for drug discovery 7 , 8 . Indeed, Motohashi et al succeeded in identifying circadian clock modulators after screening 40 crude drugs 13 .…”

Section: Discussionmentioning

confidence: 99%

“…However, as crude drug extracts are a mixture containing many active ingredients, it is also possible that the expression level of the drug targets could be different between different cells and tissues. Notably, tissue-dependent effects of crude drug extracts have also been observed 13 . This study clearly demonstrated the circadian clock modulating effects of crude drugs at the cellular, tissue, and organism levels.…”

Section: Discussionmentioning

confidence: 99%

Modulation of circadian clock by crude drug extracts used in Japanese Kampo medicine

Zhang

Kobayashi

Atsumi

et al. 2021

Sci Rep

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Circadian rhythm is an approximately 24 h endogenous biological rhythm. Chronic disruption of the circadian clock leads to an increased risk of diabetes, cardiovascular disease, and cancer. Hence, it is important to develop circadian clock modulators. Natural organisms are a good source of several medicines currently in use. Crude drugs used in Japanese traditional Kampo medicine or folk medicines are an excellent source for drug discovery. Furthermore, identifying new functions for existing drugs, known as the drug repositioning approach, is a popular and powerful tool. In this study, we screened 137 crude drug extracts to act as circadian clock modulators in human U2OS cells stably expressing the clock reporter Bmal1-dLuc, and approximately 12% of these modulated the circadian rhythm. We further examined the effects of several crude drugs in Rat-1 fibroblasts stably expressing Per2-luc, explant culture of lung from Per2::Luciferase knockin mice, and zebrafish larvae in vivo. Notably, more than half of the major ingredients of these crude drugs were reported to target AKT and its relevant signaling pathways. As expected, analysis of the major ingredients targeting AKT signaling confirmed the circadian clock-modulating effects. Furthermore, activator and inhibitor of AKT, and triple knockdown of AKT isoforms by siRNA also modulated the circadian rhythm. This study, by employing the drug repositioning approach, shows that Kampo medicines are a useful source for the identification of underlying mechanisms of circadian clock modulators and could potentially be used in the treatment of circadian clock disruption.

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“…The extract of Hericium erinaceus showed effects on behavioral rhythm, including the offset time of activity, sleep-wake cycle, and wakefulness around the end of the active phase ( 59 ). The extracts of Polyporus and Bupleuri radix induced phase delay and amplitude enhancement in mice and embryonic fibroblasts (MEFs) ( 60 ). Passionflower ( Passiflora incarnata Linnaeus ) held Generally Recognized as Safe (GRAS) status for use in foods in the USA and was listed in the European Pharmacopeia for having sedative effects.…”

Section: Plant-derived Functional Foods That Regulate Circadian Rhythmmentioning

confidence: 99%

Dietary phytochemical and metabolic disease prevention: Focus on plant proteins

et al. 2023

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Plant-based functional foods have attracted increasing research interest to validate their use in preventing metabolic disease. Since it is increasingly recognized that inflammation, oxidative stress, and circadian rhythm play vital roles in various metabolic diseases, including diabetes, obesity and non-alcoholic liver disease, plant proteins, protein hydrolysates, and food extracts that intervene in these biological processes are promising dietary supplements to prevent metabolic diseases. Here, we reviewed the recent research on plant-based foods used for metabolic disease prevention and provided new perspectives regarding the current study gaps and future directions in this field.

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Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice

Cited by 8 publications

References 31 publications

Circadian Clock Gene Expression and Drug/Toxicant Interactions as Novel Targets of Chronopharmacology and Chronotoxicology

Circadian Clock Gene Expression and Drug/Toxicant Interactions as Novel Targets of Chronopharmacology and Chronotoxicology

Modulation of circadian clock by crude drug extracts used in Japanese Kampo medicine

Dietary phytochemical and metabolic disease prevention: Focus on plant proteins

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