Polypoidal lesions associated to choroidal naevus: spectrum of pachychoroid disease?

Anzidei, Rossella; Mata, G De La; Deane, James

doi:10.1136/bcr-2018-225571

Cited by 5 publications

(8 citation statements)

References 11 publications

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“…Further, such changes might result in the growth of Type 1 neovascular membranes and eventually in the development of PCV adjacent to the melanocytic lesion, as we have observed in this case series. In addition, another possible hypothesis would be the anecdotal association of PCV and choroidal nevus in the context of paquichoroid(Anzidei) [13].…”

Section: Discussionmentioning

confidence: 99%

Choroidal nevus and polypoidal vasculopathy: case series

et al. 2020

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Background To report an association between choroidal nevus and polypoidal choroidal vasculopathy (PCV) in three patients. Case presentation We have encountered 3 isolated patients in our center presenting with subretinal exudation and a choroidal nevus that were thoroughly evaluated by slit lamp biomicroscopy, fundus photos, Fluorescein angiography (FA), indocyanine green angiography (ICG), B-scan ultrasound, and optical coherence tomography (SD-OCT—Heidelberg). The classic features of choroidal neovascularization seen on PVC were present in all 3 patients, all of whom had a substantial response to intravitreous antiangiogenic agent. OCT, Fluorescein and ICG Angiography, and Fundus autofluorescence (FAF) revealed similar findings in all cases. Discussion and conclusions We have identified a clinical pattern of PCV and choroidal nevus that can be diagnosed early using fluorescein angiography, ICG and OCT.

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Section: Discussionmentioning

confidence: 99%

Choroidal nevus and polypoidal vasculopathy: case series

et al. 2020

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“…In our patient we were able to observe various causes and/or consequences of the ischemia and the mechanical microtrauma in the Bruch’s membrane, such as glaucomatous optic neuropathy, choroidal nevus and type 1 NV associated to PPS, which demonstrates that pathogenic mechanisms of retinal disorders are interrelated in most cases. 7–9 For all these findings, we present the PPN as a new clinical entity within PD, which we can see in some advanced cases of PPS.…”

Section: Discussionmentioning

confidence: 62%

Peripapillary pachychoroid neovasculopathy: A novel entity

Hernández

Sargues

Adsuara

et al. 2020

European Journal of Ophthalmology

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Purpose: Peripapillary pachychoroid syndrome is a new variant of pachychoroid disease recently described. It is important to establish the features and pathogenic mechanisms of this novel entity and its possible association with type 1 neovascularization. The aim of this study is to report a case of peripapillary pachychoroid neovasculopathy, a novel entity of pachychoroid spectrum disease. Case report: A 51-year-old woman was referred to our macula service due to macular pigmentary changes in her right eye. On examination, best corrected visual acuity was 20/20 Snellen equivalent in both eyes. Funduscopy revealed pigmentary changes in the papillonasal bundle in her right eye with mottled autofluorescence in the same area where pigmentary changes. Spectral-domain optical coherence tomography illustrated a shallow irregular pigment epithelium detachment (PED) which appears as “double layer sign” overlying pachyvessels, with hyper-flow signal beneath it and a large network of neovascularization revealed by cross-sectional optical coherence tomography angiography. Indocyanine green angiography confirmed the pachyvessels and choroidal hyper-permeability in the peripapillary region. A diagnosis of peripapillary pachychoroid neovasculopathy was made and good visual and anatomical outcomes were achieved with a treat-and-extend regimen with intravitreal aflibercept. Conclusion: We report a novel entity within the pachychoroid spectrum disease, the peripapillary pachychoroid neovasculopathy, which could improve our understanding of the pathogenic mechanism of choroidal neovascularization in pachychoroid disorders.

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“…7,8,14 In the presence of exudation, reported treatment included photodynamic therapy, 9,11 single intravitreal anti-VEGF injections, 13,14 or a combination of both. 10 After these treatments, improvement in visual acuity and resolution of leakage were observed in all reported cases, with a follow-up up to 2 years. A singular case reported success when using focal laser photocoagulation.…”

Section: Discussionmentioning

confidence: 81%

“…The first report about polypoidal lesions in association with choroidal nevi was published in 2009 by Peiretti et al 8 Since then, single cases have been reported. 9–15 Although many cases can be safely observed, some require treatment with intravitreal antivascular endothelial growth factor (VEGF) injections, 12,16 photodynamic therapy, 9,13 or focal argon laser. 14…”

mentioning

confidence: 99%

“…7 The first report about polypoidal lesions in association with choroidal nevi was published in 2009 by Peiretti et al 8 Since then, single cases have been reported. [9][10][11][12][13][14][15] Although many cases can be safely observed, some require treatment with intravitreal antivascular endothelial growth factor (VEGF) injections, 12,16 photodynamic therapy, 9,13 or focal argon laser. 14 The aim of this multicenter study was to investigate multimodal imaging characteristics of polypoidal lesions associated with choroidal nevi, and their clinical course over a long follow-up period.…”

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confidence: 99%

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Polypoidal Lesions Associated with Choroidal Nevi

Gomel,

Goldstein,

Fung

et al. 2023

Retina

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Purpose: To investigate eyes with polypoidal lesions associated with choroidal nevi, their multimodal imaging characteristics, and long clinical follow-up. Methods: Multicenter, retrospective case series study of patients with polypoidal lesions overlying choroidal nevi. Demographic and clinical information was recorded. Multimodal imaging including colour fundus photography (CFP), optical coherence tomography (OCT), OCT angiography, fundus fluorescein angiography (FA), indocyanine angiography (ICGA) and A- and B-scan ultrasonography were analyzed for nevus and polypoidal lesion characteristics. Results: Fourteen eyes (14 patients; mean age: 70.3±6.7 years) with polypoidal lesions overlying choroidal nevi were included. The mean follow-up duration was 50.0±27.9 months (range 12-108). All nevi were pigmented on CFP, flat on ultrasonography with a mean basal diameter of 3.8±0.4 mm. In all but one eye, OCT showed a shallow irregular pigment epithelium detachment (SIRE) overlying the nevus. A total of 11/14 eyes (78.6%) had exudative activity, 9 eyes received intravitreal anti-vascular endothelial growth factor (VEGF) injections, and one eye required intravitreal anti-VEGF combined with photodynamic therapy (PDT). Mean visual acuity was 20/32 at baseline and 20/50 at final visit. Conclusions: We present the largest known cohort of eyes with polypoidal lesions associated with choroidal nevi with up to 9 years follow-up. The exudative degree of the polypoidal lesion in this condition is variable and treatment decisions should be taken on an individual basis. We hypothesize that choroidal ischemia due to altered choroidal vasculature rather than Haller layer hyperpermeability plays a role in the formation of polypoidal lesions overlying nevi.

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Polypoidal lesions associated to choroidal naevus: spectrum of pachychoroid disease?

Cited by 5 publications

References 11 publications

Choroidal nevus and polypoidal vasculopathy: case series

Choroidal nevus and polypoidal vasculopathy: case series

Peripapillary pachychoroid neovasculopathy: A novel entity

Polypoidal Lesions Associated with Choroidal Nevi

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