Polypoidal Choroidal Vasculopathy in Italy

Scassellati-Sforzolini, Baldo; Mariotti, Cesare; Bryan, Richard G.; Yannuzzi, Lawrence A.; Giuliani, Massimo; Giovannini, A.

doi:10.1097/00006982-200104000-00004

Cited by 99 publications

(91 citation statements)

References 15 publications

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“…Other studies in Caucasians and Asians, however, do not report a significant difference in age of presentation between PCV and CNV. [8][9][10] Both PCV and CNV groups showed a higher preponderance of males, which is comparable to other studies of serosanguineous maculopathy in Asians. 8,9 Absence of drusen in the fellow eye is a recognized feature of PCV.…”

Section: Discussionsupporting

confidence: 87%

Haemorrhagic pigment epithelial detachment as a predictive feature of polypoidal choroidal vasculopathy in a Chinese population

Cackett

Htoon

Wong

et al. 2009

Eye

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Purpose To determine the frequency of haemorrhagic pigment epithelial detachment (PED) among patients presenting with either polypoidal choroidal vasculopathy (PCV) or choroidal neovascularization (CNV) and calculate the degree to which the presence of a haemorrhagic PED can be used to predict the diagnosis of PCV. Methods A retrospective review of 290 eyes of 253 patients presenting to the Singapore National Eye Centre with serosanguineous maculopathy. Patients underwent ophthalmologic examination including digital colour fundus photography and stereoscopic fluorescein angiography and indocyanine green angiography (ICGA). Classification into PCV or CNV was based on ICGA findings, and presence or absence of haemorrhagic PED was documented. Results In total, 138 eyes of 123 patients were diagnosed with PCV and 152 eyes of 130 patients with CNV. A haemorrhagic PED was a significantly more common (Po0.001) presenting feature in PCV eyes (63, 45.7%) than CNV eyes (6, 3.9%) (odds ratio (OR) 20.4, 95% confidence interval (CI) 8.5-49.4). Age-related maculopathy was found significantly more frequently (Po0.001) in the unaffected fellow eye of CNV patients (57, 52.8%) than PCV patients (28, 22.8%) (OR 3.2, 95% CI 1.8-5.7). Conclusions In patients of Chinese ethnicity, a haemorrhagic PED is significantly more likely to be the presenting feature of PCV than CNV. Patients presenting with this clinical feature should make the clinician suspicious of an underlying diagnosis of PCV.

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Section: Discussionsupporting

confidence: 87%

Haemorrhagic pigment epithelial detachment as a predictive feature of polypoidal choroidal vasculopathy in a Chinese population

Cackett

Htoon

Wong

et al. 2009

Eye

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“…While in the past, some reports exclusively associated PCV with old black females patients, [1][2][3]5 recently it has also been identified in male patients, other races, and ethnic groups. 8,9,11,12,14,15 Curiously in Japanese and Chinese patients, PCV is evident more prevalent in men. 8,15 In our series of white Greek patients, the difference in sex prevalence between PCV and AMD was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] While its pathogenesis remains unclear, it is generally thought to be an inner choroidal vascular abnormality characterized by two main components: (1) a peculiar network of fine branching vessels external to choriocapillaris and (2) multiple terminal aneurysmal dilations at the border of the vascular network. These vascular dilations are sometimes visible clinically as a reddish-orange spheroidal polypoidal lesions, particularly if they are large enough and there is sufficient atrophy of the overlying retinal pigment epithelium (RPE).…”

Section: Introductionmentioning

confidence: 99%

“…It is generally accepted that indocyanine green (ICG) angiography is the examination of choice for the identification of the vascular polypoidal lesions of the PCV with great sensitivity and specificity. 2,[4][5][6]11,14 In the past, PCV has been typically described as a bilateral peripapillary disorder of middleaged hypertensive black females. [1][2][3]5 However, recent studies report that it also occurs in individuals of all races, ethnic groups, and sexes with a broad age range and that it appears to share similar characteristics with exudative age-related macular degeneration (AMD).…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3]5 However, recent studies report that it also occurs in individuals of all races, ethnic groups, and sexes with a broad age range and that it appears to share similar characteristics with exudative age-related macular degeneration (AMD). 8,9,11,12,14 Within the expanded clinical spectrum of PCV, there is a possibility that some patients who were originally diagnosed with exudative AMD may actually have exudative maculopathy secondary to PCV rather than to AMD.…”

Section: Introductionmentioning

confidence: 99%

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Polypoidal choroidal vasculopathy and exudative age-related macular degeneration in Greek population

Ladas¹,

Rouvas²,

Moschos

et al. 2004

Eye

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Purpose To study the prevalence, the clinical features, and the visual prognosis without treatment of polypoidal choroidal vasculopathy (PCV) in a large series of Greek patients presenting with exudative maculopathy. Methods The medical records, photographs, as well as fluorescein and indocyanine green (ICG) angiograms of a series of 268 consecutive elderly white Greek patients, who were originally diagnosed as having exudative age-related macular degeneration (AMD) were reviewed retrospectively. Results In all, 22 of the 268 (8.2%) patients initially suspected of having AMD were ultimately diagnosed with PCV. In 15 of the 22 (68.2%) patients with PCV, the polypoidal lesions were located in the peripapillary area. Large soft drusen were present in only two fellow eyes of the 10 (20%) patients with unilateral PCV compared with 120 fellow eyes of the 148 (81.1%) patients with unilateral AMD. At the last examination, 11 of the 22 (50%) patients with PCV and 120 of the 246 (48.8%) patients with AMD presented a visual acuity of less than 6/60 in at least one eye due to scar formation in the macula. Conclusions PCV is not an infrequent disease in Greece. A measurable number of Greek patients with findings suggestive of exudative AMD will instead have PCV. ICG angiography is important in differentiating between these two clinical entities. In Greeks, polypoidal lesions are predominately peripapillary and are not usually associated with macular drusen in the fellow eye. PCV and exudative AMD do not differ significantly in terms of their natural course and visual prognosis in Greek patients.

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