Polypoidal choroidal vasculopathy in Canada

Lam, Wai Ching; Choudhry, Netan; Wong, David T.

doi:10.1016/j.jcjo.2019.10.011

Cited by 5 publications

(4 citation statements)

References 67 publications

(54 reference statements)

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“…Left untreated, symptomatic PCV may lead to severe vision loss, so active intervention is strongly indicated [19]. Current treatment options for PCV include anti-VEGF and verteporfin photodynamic therapy (PDT).…”

Section: Management Of Pcv and Rapmentioning

confidence: 99%

“…With a longer operating wavelength (795-805 nm peak fluorescence emission), ICGA has the advantage of superior fluorescence through pigment, fluid, lipid, and hemorrhage than fluorescein dye, allowing deeper imaging into the retina [18]. Although ICGA is not widely used or available in Canada due to limited access to the dye and/ or high costs [19], this imaging modality may be especially helpful to detect PCV, reevaluate nonresponding patients, and for conditions such as central serous chorioretinopathy which may require a different therapeutic approach from that used in nAMD.…”

Section: Indocyanine Green Angiographymentioning

confidence: 99%

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Imaging Biomarkers and Their Impact on Therapeutic Decision-Making in the Management of Neovascular Age-Related Macular Degeneration

et al. 2021

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These recommendations, produced by a group of Canadian retina experts, have been developed to assist both retina specialists and general ophthalmologists in the management of vision-threatening neovascular age-related macular degeneration (nAMD). The recommendations are based on published evidence as well as collective experience and expertise in routine clinical practice. We provide an update on practice principles for optimal patient care, focusing on identified imaging biomarkers, in particular retinal fluid, as well as current and emerging therapeutic approaches. Algorithms for delivering high-quality care and improving long-term patient outcomes are provided, with an emphasis on timely and appropriate treatment to preserve and maintain vision. In the context of nAMD, increasing macular fluid or leakage on fluorescein angiography (FA) may indicate disease activity regardless of its location. Early elimination of intraretinal fluid (IRF) is of particular relevance as it is a prognostic indicator of worse visual outcomes. Robust referral pathways for second opinion and peer-to-peer consultations must be in place for cases not responding to intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy.

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Section: Management Of Pcv and Rapmentioning

confidence: 99%

Section: Indocyanine Green Angiographymentioning

confidence: 99%

Imaging Biomarkers and Their Impact on Therapeutic Decision-Making in the Management of Neovascular Age-Related Macular Degeneration

et al. 2021

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“…There are other diseases where well-documented studies have demonstrated the influence of smoking, including: polypoidal choroidal vasculopathy [19], diabetic retinopathy [20], ocular inflammations (uveitis, scleritis, episcleritis) [21], dysthyroid orbitopathy [22], as well as toxic-nutritional optic neuropathy, formerly called tobaccoalcoholic amblyopia [20], and Cuban epidemic optic neuropathy. (Fuentes Pelier D. Epidemiological and clinical evolution of patients with Cuban epidemic optic neuropathy in Santiago de Cuba.…”

Section: Introductionmentioning

confidence: 99%

Smoking and Alcoholism, Risk Factors for Papillitis?

Hodelin-Fuentes¹,

Vila-Mustelier²,

Fuentes-Pelier³

et al. 2022

BIJCROO

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Introduction. Papillitis is the inflammation of the optic nerve at the level of the optic papilla or optic disc. We did not find enough published studies that corroborate smoking and alcoholism as absolute risk factors for papillitis, however, it has been raised, so we were motivated to conduct this research, with the aim of identifying statistically significant causal association between these factors and papillitis in our hospital. Methodology. An analytical study of cases and controls was carried out in patients with papillitis treated at the Opthalmology Centre of Santiago de Cuba (2017–2019). Group 1 (Cases): 42 patients. Group 2 (Controls): 84 patients’ companions, who attended in the same period and did not present ophthalmological entities. Results. In the association of smoking with papillitis, we obtained an OR = 1.60, with CI: [0.74; 3.48], but p > 0.05. Alcoholism with papillitis resulted in an association with OR = 1.19, with CI: [0.53; 2.68] and p > 0.05. Conclusions. In our study, smoking and alcoholism had no statistically significant causal association with papillitis. Keywords: Alcoholism, smoking, papillitis, optic nerve, optic neuropathy

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“…7,8 However, ICGA is an invasive, time-consuming procedure and, because of limited availability, is often not performed routinely at the time of diagnosis in some ophthalmic practices. [9][10][11][12] Spectral domain optical coherence tomography (OCT) is a noninvasive technology that provides highresolution cross-sectional representations of the macular retina in the form of a series of B scans thus permitting detection of features that have been shown to be useful in the diagnosis of PCV. 4 Specific OCT features used to detect PLs include a sharp-peaked pigment epithelial detachment (PED), a subretinal pigment epithelial (RPE) ring-like lesion, and a complex PED outline in enface OCT. 4,13,14 The combination of these three features has been shown to achieve an area under receiver operating characteristics curve (AUC-ROC) of 0.90.…”

mentioning

confidence: 99%

Optical Coherence Tomography Features of Polypoidal Lesion Closure in Polypoidal Choroidal Vasculopathy Treated With Aflibercept

Tan

Jordan-Yu

Vyas

et al. 2022

Retina

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Purpose: To evaluate whether optical coherence tomography (OCT) can determine polypoidal lesion (PL) perfusion in polypoidal choroidal vasculopathy eyes after 12 months of aflibercept monotherapy. Polypoidal lesion perfusion status, assessed by indocyanine green angiography, is an important anatomical outcome in polypoidal choroidal vasculopathy management. Methods: Post hoc data from a prospective randomized, open-label, study in eyes with polypoidal choroidal vasculopathy undergoing monotherapy with aflibercept evaluated PL perfusion status based on indocyanine green angiography (gold standard) and OCT features from baseline to 12 months. Results: Individual PLs (110 in total) from 48 eyes (48 patients) showed at 12 months; 57/110 PLs (51.8%) were closed on indocyanine green angiography. At 12 months, eyes with closed PLs were more likely to have the following OCT features: 1) no subretinal fluid (67.1% vs. 32.9%), 2) smaller pigment epithelial detachment height (67.2 [±43.8] vs. 189.2 [±104.9] μm), 3) densely hyperreflective pigment epithelial detachment contents (84.0% vs. 16.0%), 4) an absence of a hyperreflective ring(64.0% vs. 36.0%), and a 5) indistinct overlying retinal pigment epithelial (71.4% vs. 28.6%) (all P < 0.05). The three highest performing OCT features that differentiated perfused from closed PLs were (1), (3), and (4) (area under the receiver operating characteristic curve 0.85, 0.73, and 0.70, respectively). A combination of these three features achieved an area under the receiver operating characteristic curve of 0.90. Conclusion: Polypoidal lesion closure, an important anatomical treatment outcome in polypoidal choroidal vasculopathy typically defined by indocyanine green angiography, can be accurately detected by specific OCT features.

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Polypoidal choroidal vasculopathy in Canada

Cited by 5 publications

References 67 publications

Imaging Biomarkers and Their Impact on Therapeutic Decision-Making in the Management of Neovascular Age-Related Macular Degeneration

Imaging Biomarkers and Their Impact on Therapeutic Decision-Making in the Management of Neovascular Age-Related Macular Degeneration

Smoking and Alcoholism, Risk Factors for Papillitis?

Optical Coherence Tomography Features of Polypoidal Lesion Closure in Polypoidal Choroidal Vasculopathy Treated With Aflibercept

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