2014
DOI: 10.1038/eye.2014.132
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Polypoidal choroidal vasculopathy and history of central serous chorioretinopathy

Abstract: Purpose To evaluate the possible causative role of central serous chorioretinopathy (CSC) in the development of exudative age-related macular degeneration (AMD). Methods In a cross-sectional study at an institutional setting, 150 control subjects who had senile cataract or nasolacrimal duct stenosis and who were older than 50 years were enrolled. The background data for 89 patients with typical AMD (tAMD) and 138 patients with polypoidal choroidal vasculopathy (PCV) were used for comparison. Their medical reco… Show more

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Cited by 31 publications
(18 citation statements)
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“…PCV was found more frequently in Asian patients with a history of CSCR (Toyama et al, 2014). Whether pachychoroid could predispose to either CSCR or PCV depending on associated factors such as genetic background or exogenous factors remains to be determined.…”
Section: Polypoidal Choroidal Vasculopathy (Pcv)mentioning
confidence: 96%
“…PCV was found more frequently in Asian patients with a history of CSCR (Toyama et al, 2014). Whether pachychoroid could predispose to either CSCR or PCV depending on associated factors such as genetic background or exogenous factors remains to be determined.…”
Section: Polypoidal Choroidal Vasculopathy (Pcv)mentioning
confidence: 96%
“…PCV has been shown to be associated with pathologies such as tilted disc, high myopia, retinitis pigmentosa, central serous chorioretinopathy, and AS (7)(8)(9) . Few cases with coexistence of AS and PCV have been reported in literature (3)(4)(5) .…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, antioxidant supplementation may increase plasma concentrations of lutein and other antioxidants, protect the RPE from oxidative stress, and increase the chance for reduction of subretinal fluid. Key clues to elucidating the pathogenesis of CSC may involve onset age over 30 years in most cases and the relevance of smoking, RPE atrophy, and pachychoroid [16,17] . Lipid accumulation between the RPE and Bruch's membrane starts in the 4th decade of life [40,41] .…”
Section: Discussionmentioning
confidence: 99%
“…Smoking is a definite risk factor for AMD involving PCV. Moreover, CSC has background factors in common with PCV such as pachychoroid and the effectiveness of PDT [15][16][17] . This was the impetus for antioxidant supplementation and smoking cessation being preliminarily tested in patients with chronic CSC [8] .…”
Section: Discussionmentioning
confidence: 99%