Polypodium leucotomos inhibits ultraviolet B radiation‐induced immunosuppression

Siscovick, Jonathan R.; Zapolanski, Tamar; Magro, Cynthia M.; Carrington, Kristel; Prograis, Shannon; Nussbaum, Marnie; González, Salvador; Ding, Wanhong; Granstein, Richard D.

doi:10.1111/j.1600-0781.2008.00352.x

Cited by 29 publications

(19 citation statements)

References 27 publications

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“…Previous studies reported that oral PL administered in single doses decreased UVR-induced damage in human skin (12, 13) and Alcaraz et al (14), in a pilot study, observed that topical application of a PL extract reduced the number of mice presenting tumors after UVB irradiation. Mulero et al (15) reported an immunoprotective effect of oral PL after UV irradiation in rats and Siscovick et al (16) demonstrated that oral PL prevented local and systemic photoimmunosuppression in a murine model which could explain, at least in part, its ability to inhibit UVR-induced skin cancer. Thus, we demonstrate for the first time the cutaneous antitumorigenic properties of PL given by oral route, using an experimental UVR-tumorigenic model.…”

Section: Discussionmentioning

confidence: 99%

Oral administration of Polypodium leucotomos delays skin tumor development and increases epidermal p53 expression and the anti‐oxidant status of UV‐irradiated hairless mice

Rodríguez-Yanes

Cuevas

González

et al. 2014

Experimental Dermatology

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Additional Supporting Information may be found in the online version of this article:Data S1. Methods. Table S1. Sequences of StealthTM siRNA. Table S2. Summary of antibodies and conditions used in immunohistochemistry. Figure S1. siRNA-silencing of genes individually or in combination in organotypic skin cultures reduced the expression of target genes effectively. Figure S2. Western blot analysis of 3D cultures showed a decrease of the accumulation of (pro)filaggrin, DSC1, DSG1 in SPINK5 kd cultures, but not in the double knockdowns. Abstract: Chronic exposure to ultraviolet radiation (UVR) induces skin tumors in hairless mice. Daily oral administration of a Polypodium leucotomos (PL) extract significantly delayed tumor development in PL-treated versus non-PL-treated mice. UVR and/or PL treatment modified several oxidative stress markers. In all irradiated mice, erythrocytic glutathione Stransferase (GST) activity and glutathione disulphide (GSSG) content increased and in all PL-treated mice GSSG content decreased, specially in non-irradiated animals, and total plasma anti-oxidant capacity (ORAC) increased. In dorsolateral nontumoral skin of all irradiated mice, glutathione reductase (GR) and glutathione peroxidase (GPx) activities increased and GSSG decreased in non-irradiated PL-treated animals. UVR induced a steep increase of p53 expression in epidermal cells. In nontumoral skin, this increase was significantly higher in PL-treated animals than in non-treated mice and can contribute in delaying tumor development, either by repairing the damaged DNA or by increasing apoptosis. These results reinforce the usefulness of PL as systemic photoprotective agent, especially in patients highly sensitive to UVR.

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Section: Discussionmentioning

confidence: 99%

Oral administration of Polypodium leucotomos delays skin tumor development and increases epidermal p53 expression and the anti‐oxidant status of UV‐irradiated hairless mice

Rodríguez-Yanes

Cuevas

González

et al. 2014

Experimental Dermatology

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“…Experiments using rodent models have revealed that PL blocks UVB-induced immunosuppression [36]. PL prevents the elimination of Langerhans cells induced by UV irradiation during direct UV exposure [35], or PUVA-therapy [28].…”

Section: Fernblock: a Multi-pronged Approach To Photoprotectionmentioning

confidence: 99%

Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers

González

Gilaberte

Philips

et al. 2011

IJMS

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Many phytochemicals are endowed with photoprotective properties, i.e., the capability to prevent the harmful effects of excessive exposure to ultraviolet (UV) light. These effects include photoaging and skin cancer, and immunosuppression. Photoprotection is endowed through two major modes of action: UV absorption or reflection/scattering; and tissue repair post-exposure. We and others have uncovered the photoprotective properties of an extract of the fern Polypodium leucotomos (commercial name Fernblock). Fernblock is an all-natural antioxidant extract, administered both topically (on the skin) or orally. It inhibits generation of reactive oxygen species (ROS) production induced by UV including superoxide anion. It also prevents damage to the DNA, inhibits UV-induced AP1 and NF-κB, and protects endogenous skin natural antioxidant systems, i.e., CAT, GSH, and GSSR. Its photoprotective effects at a cellular level include a marked decrease of UV-mediated cellular apoptosis and necrosis and a profound inhibition of extracellular matrix remodeling. These molecular and cellular effects translate into long-term inhibition of photoaging and carcinogenesis that, together with its lack of toxicity, postulate its use as a novel-generation photoprotective nutriceutical of phytochemical origin.

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“…Moreover, PL was also able to suppress the production of ROS that was induced by UV, therefore acting as antioxidant agent (Gonzalez et al, 2011). In addition, orally administered PL to mice resulted in inhibition of UVB radiation that triggered skin cancer (Siscovick et al, 2008).…”

Section: Fernmentioning

confidence: 99%

Botanical Antioxidants for Skin Health in the World of Cosmeceuticals

Simo

Kawal

Paliyath

et al. 2014

IJANHS

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The desire to maintain a youthful appearance in an aging population has accelerated several advancements in the cosmeceuticals market. The term cosmeceutical defines products containing bioactive substances that cannot be considered cosmetics or drugs. A variety of ingredients have been used in cosmeceuticals to improve the health and appearance of aged skin, and during the past decade, the utility of botanical natural products have gained much attention in the West. Throughout this review, the skin aging, and photoaging are discussed, mechanisms which underlie these processes are explored, and treatment options using natural plant extracts are examined.

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Polypodium leucotomos inhibits ultraviolet B radiation‐induced immunosuppression

Abstract: The ability of PL to inhibit UVB radiation-induced immune suppression may explain, in part, its ability to inhibit UVR-induced skin cancer induction in mice.

Cited by 29 publications

References 27 publications

Oral administration of Polypodium leucotomos delays skin tumor development and increases epidermal p53 expression and the anti‐oxidant status of UV‐irradiated hairless mice

Oral administration of Polypodium leucotomos delays skin tumor development and increases epidermal p53 expression and the anti‐oxidant status of UV‐irradiated hairless mice

Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers

Botanical Antioxidants for Skin Health in the World of Cosmeceuticals

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