Polyphyllin I, a strong antifungal compound against <i>Candida albicans</i>

Zhang, Yu; Zhang, Jingxiao; Sun, Jian; Zhang, Min; Liu, Xin; Yang, Longfei; Yin, Yongjie

doi:10.1111/apm.13353

Cited by 1 publication

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 2 , 5 , 29 , 30 , 31 Examples include dioscin, dracorhodin perchlorate, alantolactone, carnosol and polyphyllin I, as reported previously. 7 , 24 , 30 , 32 , 33 …”

Section: Discussionmentioning

confidence: 99%

Fangchinoline inhibits growth and biofilm of Candida albicans by inducing ROS overproduction

Yang,

Wang,

et al. 2024

J Cellular Molecular Medi

Self Cite

View full text Add to dashboard Cite

Infections caused by Candida species, especially Candida albicans, threaten the public health and create economic burden. Shortage of antifungals and emergence of drug resistance call for new antifungal therapies while natural products were attractive sources for developing new drugs. In our study, fangchinoline, a bis‐benzylisoquinoline alkaloid from Chinese herb Stephania tetrandra S. Moore, exerted antifungal effects on planktonic growth of several Candida species including C. albicans, with MIC no more than 50 μg/mL. In addition, results from microscopic, MTT and XTT reduction assays showed that fangchinoline had inhibitory activities against the multiple virulence factors of C. albicans, such as adhesion, hyphal growth and biofilm formation. Furthermore, this compound could also suppress the metabolic activity of preformed C. albicans biofilms. PI staining, followed by confocal laser scanning microscope (CLSM) analysis showed that fangchinoline can elevate permeability of cell membrane. DCFH‐DA staining suggested its anti‐Candida mechanism also involved overproduction of intracellular ROS, which was further confirmed by N‐acetyl‐cysteine rescue tests. Moreover, fangchinoline showed synergy with three antifungal drugs (amphotericin B, fluconazole and caspofungin), further indicating its potential use in treating C. albicans infections. Therefore, these results indicated that fangchinoline could be a potential candidate for developing anti‐Candida therapies.

show abstract

“… 2 , 5 , 29 , 30 , 31 Examples include dioscin, dracorhodin perchlorate, alantolactone, carnosol and polyphyllin I, as reported previously. 7 , 24 , 30 , 32 , 33 …”

Section: Discussionmentioning

confidence: 99%