Polyphosphazenes with etheric side groups: prospective biomedical and solid electrolyte polymers

Allcock, Harry R.; Austin, Paul E.; Neenan, Thomas X.; Sisko, John T.; Blonsky, Peter M.; Shriver, Duward F.

doi:10.1021/ma00160a003

Cited by 154 publications

(93 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They also synthesized methoxypoly(ethylene glycol) and ethyl-p-aminobenzoate side groups (PEG/EAB-PPPs) polyphosphazenes for delivery of water soluble anticancer agent like Doxorubicin HCl [110]. Some of the most important water-soluble polyphosphazenes such as poly[di(carboxylatophenoxy)phosphazene] (PCPP), poly[di(methoxyethoxyethoxy) phosphazene] (MEEP), and a number of others have been studied in pioneering works of H. Allcock and his coworkers [111,112]. Andrianov has reviewed about the advances in the synthesis of water-soluble polyphosphazene and their degradation pathways [113].…”

Section: Polyphosphazenesmentioning

confidence: 99%

Water Soluble Polymers for Pharmaceutical Applications

2011

View full text Add to dashboard Cite

Advances in polymer science have led to the development of novel drug delivery systems. Some polymers are obtained from natural resources and then chemically modified for various applications, while others are chemically synthesized and used. A large number of natural and synthetic polymers are available. In the present paper, only water soluble polymers are described. They have been explained in two categories (1) synthetic and (2) natural. Drug polymer conjugates, block copolymers, hydrogels and other water soluble drug polymer complexes have also been explained. The general properties and applications of different water soluble polymers in the formulation of different dosage forms, novel delivery systems and biomedical applications will be discussed.

show abstract

Section: Polyphosphazenesmentioning

confidence: 99%

Water Soluble Polymers for Pharmaceutical Applications

2011

View full text Add to dashboard Cite

show abstract

“…Cross-linking indeed surpresses the crystallisation (and offers the additional benefit of an increased mechanical stability), but simultaneously deteriorates the segmental mobility and with this the ionic conductivity. Another route towards a reduction of the crystallinity involves the use of inorganic polymers such as polyphosphazene [17][18][19][20] and polysiloxane based materials [21][22][23], in which polyether or related Li coordinating residues are attached to an inorganic backbone. The rather high flexibility of the inorganic backbone entails both, low T g values and a reduced tendency towards crystallisation and thus offers the promise of high ionic conductivity.…”

Section: Salt-in-polymer-electrolytesmentioning

confidence: 99%

Local Li Cation Coordination and Dynamics in Novel Solid Electrolytes

Wüllen¹,

Echelmeyer

Voigt

et al. 2010

Zeitschrift Für Physikalische Chemie

View full text Add to dashboard Cite

Ionic TransportResearch on solid ionic conductors for use as electrolytes in all solid state batteries still constitutes a rather vivid branch of today's materials science. Despite enormous efforts, neither the development of a solid electrolyte fulfilling the key requirements such as mechanical stability and high ionic conductivity at ambient temperature has been successful nor has an extended understanding of the local Li coordination motifs in the often amorphous systems been obtained. In this contribution, recent progress both in the development of novel solid state electrolytes with high ionic conductivity and mechanical stability and in the characterization of the local Li coordination motifs in these electrolytes from our laboratory is presented. The work was performed as a project within the framework of the Collaborative Research Centre SFB 458 "Ionic Motion in Materials with Disordered Structures -From Elementary Steps to Macroscopic Transport". Results will be given for polymer electrolytes based on polyethylene oxide (PEO), polyphosphazene (PPZ) and polyacrylonitrile (PAN) with various Li salts, nano-composites of these polymer electrolytes and Al 2 O 3 as a ceramic filler, novel inorganic/organic hybrid electrolytes, in which a mixture of an ionic liquid and Li salt is confined within the pore system of a SiO 2 glass, and a crystalline electrolyte, Li 5 La 3 Nb 2 O 12 . Employing a range of advanced solid state NMR methodologies including dipolar based NMR techniques and pulsed field gradient (PFG) NMR and impedance spectroscopy we were able to obtain a detailed knowledge about the local Li cation coordination motifs and the mechanism of Li transport in these electrolytes. Especially the hybrid electrolytes and the salt rich PAN based polymer electrolytes were identified as rather promising materials which combine a high ionic conductivity and mechanical stability.

show abstract

“…This polymer was synthesized according to literature procedures 15 but was isolated and puri®ed via a novel route exploiting the lower critical solubility temperature (LCST) behaviour of this material in aqueous solution (Harrup MK and Stewart FF, unpublished) 2-(2-Methoxyethoxy)ethanol (44.2 g, 0.368 mol) was added to 360 ml anhydrous THF under dry lightlȳ owing argon. Freshly cut metallic sodium (7.02 g, 0.306 mol) was added to the¯ask and the mix stirred at re¯ux until all the sodium was consumed.…”

Section: Synthesis Of Poly-bis-2-(2-methoxyethoxy)ethoxyphosphazene (mentioning

confidence: 99%