Polyphosphazene polymers: The next generation of biomaterials for regenerative engineering and therapeutic drug delivery

Ogueri, Kenneth S.; Ogueri, Kennedy S.; Allcock, Harry R.; Laurencin, Cato T.

doi:10.1116/6.0000055

Cited by 32 publications

(58 citation statements)

References 93 publications

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“…d, H & E-stained section illustrating the in vivo biocompatibility of the PZ-PLGA. The histological image is also demonstrating the formation of polymer spheres with pore system and collagen tissue infiltration within the pores (Deng, Nair, Nukavarapu, Kumbar, et al, 2010) 2018; Ogueri et al, 2020a;Ogueri et al, 2020b;Zhou et al, 2020).…”

Section: F I G U R Ementioning

confidence: 96%

“…The biomedical research on polyphosphazenes has garnered relatively considerable interest, especially in bone regenerative engineering and drug delivery (Allcock, 2016;Allcock & Morozowich, 2012;Baillargeon & Mequanint, 2014;Ni et al, 2020;. One of the most intriguing parts of macromolecular substitution reaction is its variability that allows the incorporation of several biologically relevant groups onto the skeletal backbone of polyphosphazenes (Ogueri et al, 2020a).…”

Section: B I Omed I C Al a S Pec Ts And Implic Ationsmentioning

confidence: 99%

“…Hence, polyphosphazenes can possess immobilization capabilities and tend to degrade to release the immobilized molecules, which can have therapeutic effects (Figure 2; Ni et al, 2020;Ogueri et al, 2020a;Strasser & Teasdale, 2020).…”

Section: B I Omed I C Al a S Pec Ts And Implic Ationsmentioning

confidence: 99%

“…Interestingly, polyphosphazenes offer the dynamism to personalize and adapt the nanofibre properties to precisely meet the needs of intended applications. Polyphosphazene nanofibres have shown excellent prospects as a carrier matrix for controlling and sustaining therapeutic drug release (Deng et al, 2011;Ogueri et al, 2020a). Currently, there is increasing interest in the utility of polyphosphazene in nanolayer device surface modification (Bates, Yousaf, Sun, Barakat, & Kueller, 2019;L.-C. Xu et al, 2018;L.…”

Section: F I G U R Ementioning

confidence: 99%

“…For example, Deng et al (Deng et al, 2011) (Allcock, 2018;Ogueri, Escobar Ivirico, et al, 2019). These stringent conditions pose a formidable hurdle to the manufacturing process development and scale-up (Ogueri et al, 2020a). Additionally, the properties of a linear polyphosphazene can sometimes be problematic to control due to its high molecular weight and broad molecular weight distribution (Ogueri et al, , 2020a.…”

Section: F I G U R Ementioning

confidence: 99%

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Biomedical applications of polyphosphazenes

Ogueri

Ude

et al. 2020

Med Devices & Sens

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Although numerous conventional organic polymers have been utilized in biomedical applications, a few numbers of them have had expected and desired success for essential medical use such as scaffolding materials for regenerative engineering, controlled drug delivery systems, and surgical sutures (Ogueri, Jafari, Ivirico, & Laurencin, 2019). This is because most organic polymers (with few exceptions) lack the design flexibility and property tunability as materials scientist and engineers often focus on harnessing and optimizing the physicochemical properties of polymers during design, scale-up, and commercialization (Ogueri, Ivirico, Nair, Allcock,

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Section: F I G U R Ementioning

confidence: 96%

Section: B I Omed I C Al a S Pec Ts And Implic Ationsmentioning

confidence: 99%

Section: B I Omed I C Al a S Pec Ts And Implic Ationsmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

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Biomedical applications of polyphosphazenes

Ogueri

Ude

et al. 2020

Med Devices & Sens

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Polyphosphazenes—A Promising Candidate for Drug Delivery, Bioimaging, and Tissue Engineering: A Review

Ilayaperumal¹,

Chelladurai²,

Vairan³

et al. 2023

Macro Materials & Eng

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Synthetic polymer materials have been surged to the forefront of research in the fields of tissue engineering, drug delivery, and biomonitoring in recent years. Biodegradable synthetic polymers are increasingly needed as transient substrates for tissue regeneration and medicine delivery. In contrast to commonly used polymers including polyesters, polylactones, polyanhydrides, poly(propylene fumarates), polyorthoesters, and polyurethanes, biodegradable polyphosphazenes (PPZs) hold great potential for the purposes indicated above. PPZ's versatility in the synthetic process has enabled the production of a variety of polymers with various physico-chemical, and biological properties have been produced, making them appropriate for biomedical applications. Biocompatible PPZs are often used as scaffolds in the regeneration of skeleton, bones, and other tissues. PPZs have also received special attention as potential drug vehicles of high-value biopharmaceuticals such as anticancer drugs. Additionally, by incorporating fluorophores into the PPZ backbone to produce photoluminescent biodegradable PPZs, the utility of polyphosphazenes is further expanded as they are used in tracking the regeneration of the target tissue as well as the fate of PPZ based scaffolds or drug delivery vehicles. This review provides a summary of the evolution of PPZ applications in the fields of tissue engineering, drug delivery, and bioimaging in recent 5 years.

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Thiophene‐based polyphosphazenes with tunable optoelectronic properties

Ogueri

Laurencin

et al. 2020

Journal of Polymer Science

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The polyphosphazene backbone provides a versatile platform to explore numerous synthesis and structure-property relationships for many technological applications. In this study, a new class of polyphosphazene semiconducting materials was synthesized via macromolecular substitution, which integrates a P N backbone with thiophene-based side groups. The synthesized thiophene-based polymers were subjected to chemical oxidation (oxidative coupling) to optimize their optoelectronic properties through side-chain chemistry. Both the spectroscopic and electronic analyses revealed that optical and electronic properties, as well as glass transition temperatures could be modulated by chemical oxidation of the polymers. The suitability of the polymers as potential semiconductors was further evaluated using their steady-state fluorescence quenching behavior in the presence of four different dopants (PC70BM, PC60BM, F4TCNQ, and TCNQ). It was found that the addition of dopant as a quencher to the polymer solutions does not form a complex in the ground state, and its excited state shows an efficient decrease in fluorescence intensity without altering the shape and peak position of the fluorescence band. The overall results demonstrate that the utilization of chemical oxidation via side-chain chemistry of polyphosphazenes offers an adaptable toolbox that can be used to make new and potentially useful polymeric semiconductors for applications in organic electronics.

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Polyphosphazene polymers: The next generation of biomaterials for regenerative engineering and therapeutic drug delivery

Cited by 32 publications

References 93 publications

Biomedical applications of polyphosphazenes

Biomedical applications of polyphosphazenes

Polyphosphazenes—A Promising Candidate for Drug Delivery, Bioimaging, and Tissue Engineering: A Review

Thiophene‐based polyphosphazenes with tunable optoelectronic properties

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