Polyphosphazene nanodrugs for targeting delivery and inflammation responsive release of curcumin to treat acute lung injury by effectively inhibiting cytokine storms

3-methyladenine ameliorates acute lung injury by inhibiting oxidative damage and apoptosis

“…Excessive inflammation caused by cytokine storms is the main contributor to the worsening of ALI [ 29 ]. MPO is predominantly expressed in neutrophils [ 30 ] and can alleviate ALI by reducing the activities and levels of its associated factors [ 31 ].…”

ICAM-1 targeted and ROS-responsive nanoparticles for the treatment of acute lung injury

“…24 h later, mice were executed, and their lungs were extracted and weighed. Subsequently, the lung tissues were homogenized, and the resulting supernatant was obtained through centrifugation 62,85,86 (10 000 rpm, 20 min, 4 °C). The supernatant was stored at −80 °C to prevent repeated freezing and thawing.…”

Advances in Organosulfur-Based Polymers for Drug Delivery Systems

“…Thiols, for instance, readily undergo disulfide exchange reactions, enabling controlled release triggered by redox conditions within the body [60]. Sulfonates and sulfates, on the other hand, add water solubility, enhancing biocompatibility and facilitating drug loading for targeted delivery [61]. Decorating the polymer backbone with specific functional groups can fine-tune its interactions with drugs and biological environments.…”