Polyphosphate, Polyphosphatase and Stress Resistance of Knockout Mutants in the PPN1 and PPN2 Genes of Saccharomyces cerevisiae
Larisa Ledova,
Tatiana Kulakovskaya,
Lubov Ryazanova
et al.
Abstract:Yeast cells possess high levels of inorganic polyphosphate, which is involved in various processes regulating vital activities. In this work, using the commercially available Saccharomyces cerevisiae knockout mutants in the PPN1 and PPN2 genes encoding polyphosphatases, we have shown that each of the two single mutations leads to a set of similar physiological effects at the stationary stage of growth on glucose: the increased resistance to manganese and peroxide stresses, lack of polyphosphatase activity in m… Show more
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