Polyphosphate coatings: A promising strategy to overcome the polycation dilemma

Le, Nguyet‐Minh Nguyen; Steinbring, Christian; Le‐Vinh, Bao; Jalil, Aamir; Matuszczak, Barbara; Bernkop‐Schnürch, Andreas

doi:10.1016/j.jcis.2020.12.019

Cited by 23 publications

(23 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…nanoemulsions. [105] Upon removal of the surface polyphosphate coating by ALP, zeta potential raised from −14.1 to +4.2 mV leading to a fourfold enhanced cellular uptake compared with control NCs on Caco-2 cells.…”

Section: Improvedmentioning

confidence: 96%

“…[182,183] The obtained polyphosphates have a polyanionic nature enabling high cation-binding capacity and can be utilized for the preparation of nanoparticles containing cationic polymers such as chitosan or polyethylene imine (PEI) via coacervation [6,185] and as coating material. [105] Polyphosphoesters being polyphosphates with higher molecular weight and side-chain modifications can be obtained by functional group conjugations to the central polyphosphate backbone due to pentavalent phosphorus atom enabling the attachment of various functional groups. These polymers can be synthesized by mainly polycondensation and also by polyaddition, transesterification, and ring-opening polymerization methods [186] and are promising excipients since they are easy to modify and comparatively stable.…”

Section: Polyphosphatesmentioning

confidence: 99%

“…[191] Phytic acid, for instance, is a biopolyphosphate that can be obtained from plants and used as a coating material for ALP-activated drug delivery systems. [105]…”

Section: Polyphosphatesmentioning

confidence: 99%

“…Promising strategy for developing zeta potential changing system [ 104] Decoration of NCs with polycationic cell penetrating peptide (CPP) followed by polyphosphate coating Poly-L-lysine decorated oily droplet coated with phytic acid and tripolyphosphate -4-fold Overcome polycation dilemma [ 105] Figure 14. ALP-activated cell-selective delivery of chemotherapeutic drug upon cell internalization.…”

Section: Improvedmentioning

confidence: 99%

mentioning

confidence: 99%

See 4 more Smart Citations

Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

Le‐Vinh

Akkuş‐Dağdeviren

et al. 2022

Advanced Therapeutics

View full text Add to dashboard Cite

Since the 1960s the membrane-bound enzyme alkaline phosphatase (ALP) has been utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents, and even from the surface of nanocarriers, this enzyme enables the design of drug delivery systems that can alter their properties in the body on demand. Anionic nanocarriers exhibiting bioinert properties can alter their surface to interactive once having reached the target site as due to an ALP-triggered cleavage of anionic phosphate groups from their surface charge converts to cationic improving for instance cellular uptake. Moreover, features such as the accumulation of nanocarriers at the target site or a targeted drug release triggered by ALP can be introduced. In addition, ALP is utilized to improve the potential of numerous diagnostic systems. Within this review, one provides an overview about the activity, selectivity, and distribution of this enzyme, as well as the great variety of applications in drug delivery and diagnostics making use of it.

show abstract

Section: Improvedmentioning

confidence: 96%

Section: Polyphosphatesmentioning

confidence: 99%

“…[191] Phytic acid, for instance, is a biopolyphosphate that can be obtained from plants and used as a coating material for ALP-activated drug delivery systems. [105]…”

Section: Polyphosphatesmentioning

confidence: 99%

Section: Improvedmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

Le‐Vinh

Akkuş‐Dağdeviren

et al. 2022

Advanced Therapeutics

View full text Add to dashboard Cite

show abstract

Bioinert, Stealth or Interactive: How Surface Chemistry of Nanocarriers Determines Their Fate In Vivo

Friedl

Nele

Rosa

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

Nanocarriers (NCs) have emerged as powerful tools to improve drug solubility, to promote drug transport across membranes, to protect their payload from premature degradation, and to deliver drugs in a controlled and targeted manner. Their performance strongly depends on the surface chemistry, which governs their interaction with the biological environment. Bioinert and stealth surface features are advantageous to avoid unintended interactions with endogenous surfaces at off‐target sites and with the immune system, whereas at the target site these carriers should be highly interactive guaranteeing intracellular delivery of their payload. These key surface properties—bioinert and stealth versus interactive at the target site—are in contradiction to each other so that the best compromise between them has to be found. Alternatively, surface structures interacting preferentially with the membrane of target cells can be utilized. Stimuli‐responsive surfaces able to convert from bioinert and stealth to interactive at the target site have been recently introduced. A deepened understanding of how these different approaches influence the performance of NCs in the body is of particular importance in order to improve their efficacy. This review focuses on the surface chemistry of NCs providing the best compromise between bioinert and stealth versus interactive features.

show abstract

Charge‐Reversible Nanoparticles: Advanced Delivery Systems for Therapy and Diagnosis

Veider,

Sanchez Armengol,

Bernkop‐Schnürch

2023

Small

View full text Add to dashboard Cite

The past two decades have witnessed a rapid progress in the development of surface charge‐reversible nanoparticles (NPs) for drug delivery and diagnosis. These NPs are able to elegantly address the polycation dilemma. Converting their surface charge from negative/neutral to positive at the target site, they can substantially improve delivery of drugs and diagnostic agents. By specific stimuli like a shift in pH and redox potential, enzymes, or exogenous stimuli such as light or heat, charge reversal of NP surface can be achieved at the target site. The activated positive surface charge enhances the adhesion of NPs to target cells and facilitates cellular uptake, endosomal escape, and mitochondrial targeting. Because of these properties, the efficacy of incorporated drugs as well as the sensitivity of diagnostic agents can be essentially enhanced. Furthermore, charge‐reversible NPs are shown to overcome the biofilm formed by pathogenic bacteria and to shuttle antibiotics directly to the cell membrane of these microorganisms. In this review, the up‐to‐date design of charge‐reversible NPs and their emerging applications in drug delivery and diagnosis are highlighted.

show abstract

Polyphosphate coatings: A promising strategy to overcome the polycation dilemma

Cited by 23 publications

References 38 publications

Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

Bioinert, Stealth or Interactive: How Surface Chemistry of Nanocarriers Determines Their Fate In Vivo

Charge‐Reversible Nanoparticles: Advanced Delivery Systems for Therapy and Diagnosis

Contact Info

Product

Resources

About