Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats

Ong, Khang Wei; Hsu, Annie; Song, Lixia; Huang, Dejian; Tan, Benny Kwong Huat

doi:10.1016/j.jep.2010.10.046

Cited by 111 publications

(71 citation statements)

References 33 publications

(33 reference statements)

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“…It shows that Vernonia plays significant role in herbal medicine. Vernonia amygadlinawhich is an indigenous leafy vegetable in Nigeria has been part of herbal recipes for the treatment of various ailments [74][75][76][77]. The other genera mentioned in the survey had only one species each.…”

Section: Resultsmentioning

confidence: 99%

Ethno-medicines for Mosquito Transmitted Diseases from South-western Nigeria

Sonibare¹,

Okorie²,

Aremu³

et al. 2015

JNR

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Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

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Section: Resultsmentioning

confidence: 99%

Ethno-medicines for Mosquito Transmitted Diseases from South-western Nigeria

Sonibare¹,

Okorie²,

Aremu³

et al. 2015

JNR

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“…In animal models of both T1D and T2D, polyphenols of different origin were reported to lower blood glucose levels (Al-Awwadi et al 2004;Su, Hung, and Chen 2006;Ciocoiu et al 2009;Dixit and Kar 2010;Ong et al 2011). The hypoglycemic effect can be caused by multiple mechanisms.…”

Section: Wwwintechopencommentioning

confidence: 99%

“…The hypoglycemic effect can be caused by multiple mechanisms. Polyphenols can decrease glucose absorption from intestine as they inhibit amylase, a polysaccharide-hydrolyzing enzyme (Ong et al 2011). On the other hand, some studies show that polyphenols enhance glucose uptake by muscle cells via increasing expression of glucose transporter Glut4 (Cao et al 2007;Ong et al 2011).…”

Section: Wwwintechopencommentioning

confidence: 99%

“…Polyphenols can decrease glucose absorption from intestine as they inhibit amylase, a polysaccharide-hydrolyzing enzyme (Ong et al 2011). On the other hand, some studies show that polyphenols enhance glucose uptake by muscle cells via increasing expression of glucose transporter Glut4 (Cao et al 2007;Ong et al 2011). The third possible mechanism of lowering blood glucose by these compounds could be an inhibition of gluconeogenesis in liver by inhibiting glucose-6-phosphatase, a key enzyme in this process (Ong et al 2011).…”

Section: Wwwintechopencommentioning

confidence: 99%

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Mitochondria and Antioxidants: The Active Players in Islet Oxidative Stress

Votyakova¹,

Bottino²,

Trucco³

2012

Chemical Biology

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“…It has been scientifically documented that the roots of the plant has been used as toothache and gingivitis as a result of its proven antimicrobial activity [12]. V. amygdalina plant has been researched upon and the experimental evidence for its use in diabetes management as reported by Udoamaka [13] included; 80 mg/kg aqueous extract of the leaves produced a dose dependent decrease in blood glucose levels in normal and alloxan-induced diabetic rabbits [14]; chronic intake of 400mg/kg ethanolic extract of the fresh leaves significantly decreased fasting blood glucose levels, increased serum and pancreatic insulin levels, increased the activity of liver antioxidant enzymes as well as increased the expression and distribution of Glut 4 receptors in STZ-induced diabetic rats [15]; 150ml of a (1:1:1) decoction mix of the leaves of Vernonia amygdalina, Ocimum gratissimum and Gongronema latifolium decreased baseline blood glucose levels in normal subjects when preadministered to normal subjects 45 minutes before an OGTT [16], however the selected plant has not been evaluated simultaneously for its potent inhibition of α-and β-glucosidases, maltase glucoamylase, aldose reductase (ALR1 and ALR2) and identifying the bioactive compounds of the chloroform crude extract.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Evaluation of Vernonia amygdalina Extracts for its Antidiabetic Potentials

E¹,

A²,

O.T³

et al. 2018

ijSciences

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Abstract:Background: There is increase in the demand for the use of medicinal plants for the treatment of various ailments such as cancer, hypertension and diabetes locally as a result of the inability of the synthesized drugs to completely eradicate the ailments and also with the attendant side effects attached to the use of drugs. Objective: The aim of this research work was to investigate the Aldose reductase, α-glucosidase, β -glucosidase and maltase glucoamylase inhibitory potential of the crude extracts of Vernonia amygdalina, and characterizing the extracts. Materials and method:The leaves of the plant was obtained, air dried and turned to powdered form using commercial grinding machine with dimension 34×38×75. The extracted crudes were subjected into in-vitro studies of the inhibitory potentials using recommended protocols. The IC 50 values were calculated using Graph pad prism 5.0 software and the identified compounds were screened for drug properties using ONLINE OSIRIS server explorer. Results: The (IC 50 0.6 ± 0.03 μg/mL) of the chloroform extract was better than the methanolic extract of IC 50 (1.532±0.63μg/mL) and the results were better than the acarbose standard (IC 50 234.6 + 2.01μM). The maltase glucoamylase inhibitory potentials of the chloroform and methanolic extracts in the range of IC 50 1.112 ± 0.90 μg/mL and 1.315 ± 0.7 μg/mL. The β-glucosidase screening of the extracts results indicated that they do not have good selective inhibitor properties. IC 50 of Aldose reductase (ALR2) of chloroform extract IC 50 (1.339+0.264μg/mL) was better than that of methanolic extract of IC 50 (1.437+0.6μg/mL) and these values were better when compared with the standard, sorbinil of IC 50 (3.10 +0.20μM).The aldehyde reductase (ALR1) of methanolic extract IC 50 (0.325+0.02μg/mL) was better than that of chloroform extract of IC 50 (0.964+0.16μg/mL) and when compared with standard 10mM vaproic acid IC 50 (57.4 +10μM).The GC-MS of the chloroform extract revealed compounds which were screened computationally to for various drug properties such as drug likeness, cLogS, cLogP, H-bond acceptor and H-bond Donor. Conclusion: The promising inhibitory potential of the plant extracts and characterization of the extract is an indication of the usefulness of the plant for the treatment of diabetes.

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Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats

Cited by 111 publications

References 33 publications

Ethno-medicines for Mosquito Transmitted Diseases from South-western Nigeria

Ethno-medicines for Mosquito Transmitted Diseases from South-western Nigeria

Mitochondria and Antioxidants: The Active Players in Islet Oxidative Stress

Characterization and Evaluation of Vernonia amygdalina Extracts for its Antidiabetic Potentials

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