“…In the same line with our findings, other systematic reviews and meta-analyses confirmed the beneficial effects of GPCP on the obesity-induced chronic inflammation [ 120 ], lipid profile [ 121 ], blood glucose [ 87 ], systolic blood pressure, heart rate [ 57 , 122 ], endothelial function [ 56 ], liver and heart functions [ 87 ], metabolic syndrome, and type 2 diabetes [ 120 ]. In addition, the significant impact of GPCP was reported on oxidative stress in patients with Type 2 diabetes [ 23 , 44 ], pre hypertension [ 1 , 123 ], overweight [ 39 ], acute lymphoblastic leukemia [ 41 ], CVD [ 100 , 124 ], systemic sclerosis [ 96 ], Chronic Obstructive Pulmonary Disease [ 32 ], hemodialysis patient [ 46 , 125 , 126 ], hyperlipidemia [ 127 ], smoker [ 128 ], and healthy subjects [ 21 , 26 , 40 , 42 , 90 , 92 , 94 , 101 , 102 , 105 , 114 , 115 , 118 ]. In contrast with our results, some RCTs [ 36 , 38 , 43 , 95 , 104 , 106 , 116 , 119 , 129 ] reported no significant effect of GPCP on oxidative stress.…”