Polyphenols Nanoencapsulation for Therapeutic Applications

A, Di Salle

doi:10.4172/2167-7956.1000139

Cited by 20 publications

(10 citation statements)

References 114 publications

(186 reference statements)

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“…In this context, the reduction of lipid peroxidation using lipophilic antioxidants derived from natural antioxidant molecules was a logical choice to reduce deleterious oxidative stress. Four natural phenolic derivatives were selected in this study for their potent antioxidant properties or for their previous evaluation in RPE cell assays: phloroglucinol [15], resveratrol [14], catechin, and quercetin [46,47]. Among them, natural quercetin has been largely evaluated in the field of retina dystrophies for its direct or indirect antioxidant properties: Cao et al [18] demonstrated the ability of quercetin to protect human RPE cells from oxidative stress in vitro via suppression of pro-inflammatory cytokines and inhibition of apoptosis pathway.…”

Section: Discussionmentioning

confidence: 99%

New Lipophenol Antioxidants Reduce Oxidative Damage in Retina Pigment Epithelial Cells

et al. 2018

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Age-related macular degeneration (AMD) is a multifactorial pathology and its progression is exacerbated by oxidative stress. Oxidation and photo-oxidation reactions modify lipids in retinal cells, contribute to tissue injury, and lead to the formation of toxic adducts. In particular, autofluorescent pigments such as N-retinylidene-N-retinylethanolamine (A2E) accumulate as lipofuscin in retinal pigment epithelial cells, contribute to the production of additional reactive oxygen species (ROS), and lead to cell degeneration. In an effort to develop efficient antioxidants to reduce damage caused by lipid oxidation, various natural polyphenols were structurally modified to increase their lipophilicity (lipophenols). In this study, resveratrol, phloroglucinol, quercetin and catechin were selected and conjugated to various polyunsaturated fatty acids (PUFAs) using classical chemical strategies or enzymatic reactions. After screening for cytotoxicity, the capacity of the synthesized lipophenols to reduce ROS production was evaluated in ARPE-19 cells subjected to H2O2 treatment using a dichlorofluorescein diacetate probe. The positions of the PUFA on the polyphenol core appear to influence the antioxidant effect. In addition, two lipophenolic quercetin derivatives were evaluated to highlight their potency in protecting ARPE-19 cells against A2E photo-oxidation toxicity. Quercetin conjugated to linoleic or α-linolenic acid were promising lipophilic antioxidants, as they protected ARPE-19 cells from A2E-induced cell death more effectively than the parent polyphenol, quercetin.

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Section: Discussionmentioning

confidence: 99%

New Lipophenol Antioxidants Reduce Oxidative Damage in Retina Pigment Epithelial Cells

et al. 2018

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“…One promising solution to low oral bioavailability is the development of nanodelivery systems able to maintain the structural integrity of the bioactive molecules (95).…”

Section: Other Considerations and Future Needsmentioning

confidence: 99%

“…Furthermore, research should shift the focus to studying antimicrobial properties of phenolics in vivo (92)(93)(94)(95)(96)(97)(98)(99)(100)(101). More animal and human experiments should be conducted in this field to establish general principles affecting their absorption in vivo.…”

Section: Other Considerations and Future Needsmentioning

confidence: 99%

Challenges to antimicrobial susceptibility testing of plant-derived polyphenolic compounds

Bubonja‐Šonje

Knežević

Abram

2020

Archives of Industrial Hygiene and Toxicology

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As multidrug resistance gains momentum, the last two decades have seen an ever-growing interest in the antimicrobial properties of plant extracts and plant-derived compounds. Most of the focus is on polyphenols – a large and diverse group of phytochemicals with strong antibacterial activity. Testing methods provide reliable results as long as they follow standard procedures. However, methods and procedures used in antimicrobial susceptibility testing (AST) are often too diverse to allow comparison of results. The lack of uniformity and comparability is much owed to the absence of guidelines. The focus of this review is to give a critical overview of different methods used in the assessment of polyphenols antimicrobial efficacy and to highlight the importance of their standardisation.

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“…Natural products and isolated natural compounds face several challenges and weaknesses that can compromise their therapeutic efficacy, including poor bioavailability and decreased water solubility, physical and chemical instabilities, rapid metabolism, and BBB crossing. These reviews of the literature provide more details [199][200][201]. However, numerous natural compounds, including resveratrol [202] and curcumin [203,204], have been reported to have low bioavailability and limited stability due to degradation or transformation into inactive derivatives [205,206].…”

Section: Limitations Future Prospects and Challengesmentioning

confidence: 99%

Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges

et al. 2021

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Natural products derived from plants, as well as their bioactive compounds, have been extensively studied in recent years for their therapeutic potential in a variety of neurodegenerative diseases (NDs), including Alzheimer’s (AD), Huntington’s (HD), and Parkinson’s (PD) disease. These diseases are characterized by progressive dysfunction and loss of neuronal structure and function. There has been little progress in designing efficient treatments, despite impressive breakthroughs in our understanding of NDs. In the prevention and therapy of NDs, the use of natural products may provide great potential opportunities; however, many clinical issues have emerged regarding their use, primarily based on the lack of scientific support or proof of their effectiveness and patient safety. Since neurodegeneration is associated with a myriad of pathological processes, targeting multi-mechanisms of action and neuroprotection approaches that include preventing cell death and restoring the function of damaged neurons should be employed. In the treatment of NDs, including AD and PD, natural products have emerged as potential neuroprotective agents. This current review will highlight the therapeutic potential of numerous natural products and their bioactive compounds thatexert neuroprotective effects on the pathologies of NDs.

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Polyphenols Nanoencapsulation for Therapeutic Applications

Cited by 20 publications

References 114 publications

New Lipophenol Antioxidants Reduce Oxidative Damage in Retina Pigment Epithelial Cells

New Lipophenol Antioxidants Reduce Oxidative Damage in Retina Pigment Epithelial Cells

Challenges to antimicrobial susceptibility testing of plant-derived polyphenolic compounds

Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges

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