Polyphenols modulate calcium-independent mechanisms in human arterial tissue-engineered vascular media

Diebolt, Myriam; Laflamme, Karina; Labbé, Raymond; Auger, François A.; Germain, Lucie; Andriantsitohaina, Ramaroson

doi:10.1016/j.jvs.2007.05.031

Cited by 14 publications

(8 citation statements)

References 31 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, procyanidins can increase the peripheral blood flow and improve microcirculation through the relaxation of the arterial walls and enhancing the capillary resistance [92]. Procyanidins also protect the endothelial cells from peroxynitrite cell damage and the cardiomyocytes against oxidative stress [93], regulate contraction and the signaling pathways in arteries [94], and also improve the endothelium-dependent relaxation in a human artery [95]. Given that free radicals and oxidative stress play an important role in a wide range of cardiovascular diseases, including heart valve failure and cardiomyopathy, the cardioprotective efficacy of procyanidins can be attributed to their superior antioxidant properties compared to vitamins, such as E, C and beta-carotene [96].…”

Section: Polyphenols In Biomedical Applicationsmentioning

confidence: 99%

Polyphenol uses in biomaterials engineering

et al. 2018

View full text Add to dashboard Cite

Polyphenols are micronutrients obtained from diet that have been suggested to play an important role in health. The health benefits of polyphenols and their protective effects in food systems as antioxidant compounds are well known and have been extensively investigated. However, their functional roles as a "processing cofactor" in tissue engineering applications are less widely known. This review focuses on the functionality of polyphenols and their application in biomaterials. Polyphenols have been used to stabilize collagen and to improve its resistance to degradation in biological systems. Therefore, they have been proposed to improve the performance of biomedical devices used in cardiovascular systems by improving the mechanical properties of grafted heart valves, enhancing microcirculation through the relaxation of the arterial walls and improving the capillary blood flow and pressure resistance. Polyphenols have been found to stimulate bone formation, mineralization, as well as the proliferation, differentiation, and the survival of osteoblasts. These effects are brought about by the stimulatory effect of polyphenols on osteoblast cells and their protective effect against oxidative stress and inflammatory cytokines. In addition, polyphenols inhibit the differentiation of the osteoclast cells. Collectively, these actions lead to promote bone formation and to reduce bone resorption, respectively. Moreover, polyphenols can increase the cross-linking of dentine and hence its mechanical stability. Overall, polyphenols provide interesting properties that will stimulate further research in the bioengineering field.

show abstract

Section: Polyphenols In Biomedical Applicationsmentioning

confidence: 99%

Polyphenol uses in biomaterials engineering

et al. 2018

View full text Add to dashboard Cite

show abstract

“…OPCs are found in a wide range of other plants, including common foods in an ordinary diet,3,4 and are widely consumed as antioxidant supplements. Recent research has focused primarily on the clinical efficacy of PBE, including a wide range of cardiovascular benefits 5,6. In addition to their antioxidant properties, PBE has been reported to lower blood pressure and to improve glycemic control, the lipid profile, fatty acid synthesis, and the peripheral circulation 7…”

Section: Introductionmentioning

confidence: 99%

Oral administration of French maritime pine bark extract (Flavangenol®) improves clinical symptoms in photoaged facial skin

Furumura¹,

Sato²,

Kusaba³

et al. 2012

CIA

View full text Add to dashboard Cite

BackgroundFrench maritime pine bark extract (PBE) has gained popularity as a dietary supplement in the treatment of various diseases due to its polyphenol-rich ingredients. Oligometric proanthocyanidins (OPCs), a class of bioflavonoid complexes, are enriched in French maritime PBE and have antioxidant and anti-inflammatory activity. Previous studies have suggested that French maritime PBE helps reduce ultraviolet radiation damage to the skin and may protect human facial skin from symptoms of photoaging. To evaluate the clinical efficacy of French maritime PBE in the improvement of photodamaged facial skin, we conducted a randomized trial of oral supplementation with PBE.MethodsOne hundred and twelve women with mild to moderate photoaging of the skin were randomized to either a 12-week open trial regimen of 100 mg PBE supplementation once daily or to a parallel-group trial regimen of 40 mg PBE supplementation once daily.ResultsA significant decrease in clinical grading of skin photoaging scores was observed in both time courses of 100 mg daily and 40 mg daily PBE supplementation regimens. A significant reduction in the pigmentation of age spots was also demonstrated utilizing skin color measurements.ConclusionClinically significant improvement in photodamaged skin could be achieved with PBE. Our findings confirm the efficacy and safety of PBE.

show abstract

“…We have already demonstrated that TEVM display fundamental histological, functional and many pharmacological characteristics of the human artery from which they were originally isolated [15,16]. Moreover, the use of TEVA, a media or the combination of both lead to better understandings of the effects of MPs from apoptotic T-lymphocytes in the modulation of vascular tone [8].…”

Section: Discussionmentioning

confidence: 99%

“…Although these engineered vessels have been largely used to perform pharmacological studies [10,11,15,16], they are not representative of the whole vessel. It should to be noted that both LPS-treated TEVM and aortic rings from mice treated with LPS display the same hyporeactivity and, in both experimental conditions, IL-10 was able to restore contraction.…”

Section: Limitations Of the Studymentioning

confidence: 99%

Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media

et al. 2013

Self Cite

View full text Add to dashboard Cite

During sepsis, inflammation can be orchestrated by the interaction between circulating and vascular cells that, under activation, release MPs (microparticles). Previously, we reported that increased circulating MPs in patients with sepsis play a pivotal role in ex vivo vascular function suggesting that they are protective against vascular hyporeactivity. The present study was designed to investigate the effects of MPs from patients with sepsis on the contractile response of TEVM (tissue-engineered vascular media). TEVM that were composed only of a media layer were produced by tissue engineering from human arterial SMCs (smooth muscle cells) isolated from umbilical cords. TEVM was incubated with MPs isolated from whole blood of 16 patients with sepsis. TEVM were incubated for 24 h with MPs and used for the study of vascular contraction, direct measurements of NO and O2- (superoxide anion) production by EPR and quantification of mRNA cytokine expression. MPs from patients with sepsis increased contraction induced by histamine in TEVM. This effect was not associated with inflammation, neither linked to the activation of NF-κB (nuclear factor κB) pathway nor to the increase in iNOS (inducible NO synthase) and COX (cyclo-oxygenase)-2 expression. In contrast, mRNA expression of IL (interleukin)-10 was enhanced. Then, we investigated the effect of IL-10 on vascular hyporeactivity induced by LPS (lipopolysaccharide). Although IL-10 treatment did not modify the contractile response in TEVM by itself, this interleukin restored contraction in LPS-treated TEVM. In addition, IL-10 treatment both prevented vascular hyporeactivity induced by LPS injection in mice and improved survival of LPS-injected mice. These findings show an association between the capacity of MPs from patients with sepsis to restore vascular hyporeactivity induced by LPS and their ability to increase IL-10 in the tissue-engineered blood vessel model.

show abstract

Polyphenols modulate calcium-independent mechanisms in human arterial tissue-engineered vascular media

Abstract: The use of arterial TEVM, brings new insights into the mechanisms by which polyphenols regulate vascular contraction in the human artery.

Cited by 14 publications

References 31 publications

Polyphenol uses in biomaterials engineering

Polyphenol uses in biomaterials engineering

Oral administration of French maritime pine bark extract (Flavangenol®) improves clinical symptoms in photoaged facial skin

Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media

Contact Info

Product

Resources

About

Polyphenols modulate calcium-independent mechanisms in human arterial tissue-engineered vascular media

Abstract: The use of arterial TEVM, brings new insights into the mechanisms by which polyphenols regulate vascular contraction in the human artery.

Cited by 14 publications

References 31 publications

Polyphenol uses in biomaterials engineering

Polyphenol uses in biomaterials engineering

Oral administration of French maritime pine bark extract (Flavangenol&reg;) improves clinical symptoms in photoaged facial skin

Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media

Contact Info

Product

Resources

About

Oral administration of French maritime pine bark extract (Flavangenol®) improves clinical symptoms in photoaged facial skin