Polyphenols inhibit promotional phase of tumorigenesis: Relevance of superoxide radicals

Abstract

Ellagic acid (EA), tannic acid (TA), caffeic acid (CA), and ferulic acid (FA) offer considerable promise as anticarcinogens. The role of these dietary polyphenols was investigated in the promotional phase of carcinogenesis. Topical application of polyphenols simultaneously with phorbol-12-myristate-13-acetate (PMA) or mezerein resulted in significant protection against 7,12-dimethyl-benz[a]anthracene-induced skin tumors in mice. Caffeic acid was the most effective inhibitor of tumor promotion. In vivo and in vitro treatment of murine peritoneal macrophages with the tumor promoters resulted in stimulation of superoxide anion radical formation. Tannic acid, caffeic acid, and ferulic acid were stronger inhibitors of PMA- and mezerein-induced superoxide anion radical than ellagic acid in in vivo and in vitro conditions. Treatment of [1(3)-14C]glycerol- or [methyl-14C]choline chloride-labeled resident or thioglycollate-elicited macrophages with PMA and mezerein led to accumulation of radioactive diacylglycerol equivalents. The polyphenols were capable of inhibiting these releases.

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

“…Ferulic acid further exhibited anticarcinogenic effects in benzo[a]pyrene-induced pulmonary adenoma development in mice (Lesca, 1983) and ameliorated the 7,12-dimethylbenz[a]anthracene-induced development of skin cancers in mice (Kaul and Khanduja, 1998;Alias et al, 2009), mammary adenocarcinomas in rats (Baskaran et al, 2010), and carcinomas in the buccal pouch of Syrian golden hamsters (Balakrishnan et al, 2008). At the administered dosages, ferulic acid was not carcinogenic (Kaul and Khanduja, 1998;Balakrishnan et al, 2008;Alias et al, 2009;Baskaran et al, 2010).…”

“…At the administered dosages, ferulic acid was not carcinogenic (Kaul and Khanduja, 1998;Balakrishnan et al, 2008;Alias et al, 2009;Baskaran et al, 2010). Moreover, in human breast cancer (T47D) cells, ferulic acid inhibited proliferation at an IC 50 of 2.3 nM (Kampa et al, 2004), although inhibition of cell proliferation and apoptosis could not be reproduced in other human breast cancer cell lines at ferulic acid concentrations of up to 75 mM (Serafim et al, 2011).…”

Antimutagenicity of Mono-, Di-, and Tricaffeoylquinic Acid Derivatives Isolated from Sweetpotato (Ipomoea batatasL.) Leaf

“…5) Polyphenolics have attracted special attention because they can protect the human body from the oxidative stress which may cause many diseases including cancer, aging and cardiovascular problems. [6][7][8][9][10][11][12][13][14][15] However, little is known about the relationship between the physiological function of the caŠeoyl derivatives of the sweetpotato leaf and their chemical structures.…”

Evaluating Antiinflammatory and Antiandrogenic Effects of Garden Cress (Lepidium sativum L.) in HaCaT cells

“…Among the polyphenols found in our extract, efficacy of fumaric acid was depicted in psoriasis [15,16]. In various clinical studies ferulic acid was found to have protective effects against damage caused by the UV irradiation and chemically induced skin tumorigenesis [17][18][19]. Ferulic acid and sinapic acid analogues were reported to inhibit UVA induced oxidative stress in skin [20].…”