Polyphenols in madhumega chooranam, a Siddha medicine, ameliorates carbohydrate metabolism and oxidative stress in type II diabetic rats

Babu, Chidambaram Saravana; Sathiya, S.; Anbarasi, C.; Prathyusha, Nettam; Ramakrishnan, G.; Kalaivani, P.; Priya, Raju Jyothi; Kesavanarayanan, Krishnamoorthy Selvarajan; Mahadevan, Murugappapillai V; Thanikachalam, Sadagopan

doi:10.1016/j.jep.2012.04.003

Cited by 9 publications

(3 citation statements)

References 26 publications

(22 reference statements)

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“…Many Siddha polyherbal formulations like Avarai kudineer, Madhumega chooranam, Kabasura kudineer etc., are already reported for their antidiabetic activity [11][12][13]. In that context we have developed a formulation called Athiyadhi Kashayam (AK) a mixture of Ficus racemosa, Cassia auriculata, Cassia fistula, Syzygium cumini and Salacia reticulata.…”

Section: Introductionmentioning

confidence: 99%

"Exploring the Antidiabetic and Antioxidant Potential of Athiyadhi Kashayam: Investigating mechanisms of action in Siddha Medicine"

2024

eatp

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Diabetes mellitus is a serious condition that affects the majority of the population and leads to mortality, and it may increase tremendously by 2025. The disease is characterized by elevated blood glucose levels resulting from insulin resistance and insufficiency. This leads to various metabolic disorders that affect various organs. The free radicals generated during diabetes conditions are known to elevate the condition much more severely. The antioxidant activity against free radicals and the inhibition of enzymes that are involved in raising blood glucose levels inhibition might prove effective in the treatment of type 2 diabetes. The Siddha formulation Athiyadi Kashayam (AK) was analyzed for its enzyme inhibition study and antioxidant activity in vitro. The results proved the enhanced antioxidant potential. The drug AK also inhibited the enzymes -amylase and glucosidase in a concentration-dependent manner. Thus AK proved to be effective in treating Type 2 Diabetes.

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Section: Introductionmentioning

confidence: 99%

"Exploring the Antidiabetic and Antioxidant Potential of Athiyadhi Kashayam: Investigating mechanisms of action in Siddha Medicine"

2024

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“…Hydroxycinnamic acid (HA) is present in higher concentration in Biomolecules 2023, 13, 1196 2 of 14 the outer part of ripened fruits which includes caffeic acid, ferulic acid, p-coumaric and sinapic acid [3]. Phenolic acids are potent antioxidants and have several benefits such as being neuroprotective [4], antidiabetic [5], anticancer, anti-inflammatory, etc. [6].…”

Section: Introductionmentioning

confidence: 99%

Polyphenols, Autophagy and Neurodegenerative Diseases: A Review

Chandrasekaran,

Hediyal,

Anand

et al. 2023

Biomolecules

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Polyphenols are secondary metabolites from plant origin and are shown to possess a wide range of therapeutic benefits. They are also reported as regulators of autophagy, inflammation and neurodegeneration. The autophagy pathway is vital in degrading outdated organelles, proteins and other cellular wastes. The dysregulation of autophagy causes proteinopathies, mitochondrial dysfunction and neuroinflammation thereby contributing to neurodegeneration. Evidence reveals that polyphenols improve autophagy by clearing misfolded proteins in the neurons, suppress neuroinflammation and oxidative stress and also protect from neurodegeneration. This review is an attempt to summarize the mechanism of action of polyphenols in modulating autophagy and their involvement in pathways such as mTOR, AMPK, SIRT-1 and ERK. It is evident that polyphenols cause an increase in the levels of autophagic proteins such as beclin-1, microtubule-associated protein light chain (LC3 I and II), sirtuin 1 (SIRT1), etc. Although it is apparent that polyphenols regulate autophagy, the exact interaction of polyphenols with autophagy markers is not known. These data require further research and will be beneficial in supporting polyphenol supplementation as a potential alternative treatment for regulating autophagy in neurodegenerative diseases.

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“…5 It has been found that Rutin exhibited an increase in BW up to 12.1%, and Madhumega chooranam can increase BW by 42.7%. 13,14 Insulin comprises the most potent anabolic hormone known and Beta cells are responsible for producing; it is known that the death of these cells could be caused by hyperglycemia, and compounds with pyranocoumarin structure can improve it. 9,15,16 The increase in ROS can lead to death of Beta cells; therefore, an improvement in BW may be due to that DOAcK carries out better control of hyperglycemia by decreasing ROS.…”

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confidence: 99%

Antidiabetic effect, antioxidant activity, and toxicity of 3′,4′-Di-O-acetyl-cis-khellactone in Streptozotocin-induced diabetic rats

Domínguez-Mendoza

Cornejo-Garrido

Burgueño‐Tapia

et al. 2016

Bioorganic & Medicinal Chemistry Letters

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Polyphenols in madhumega chooranam, a Siddha medicine, ameliorates carbohydrate metabolism and oxidative stress in type II diabetic rats

Cited by 9 publications

References 26 publications

"Exploring the Antidiabetic and Antioxidant Potential of Athiyadhi Kashayam: Investigating mechanisms of action in Siddha Medicine"

"Exploring the Antidiabetic and Antioxidant Potential of Athiyadhi Kashayam: Investigating mechanisms of action in Siddha Medicine"

Polyphenols, Autophagy and Neurodegenerative Diseases: A Review

Antidiabetic effect, antioxidant activity, and toxicity of 3′,4′-Di-O-acetyl-cis-khellactone in Streptozotocin-induced diabetic rats

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