Polyphenols from the Plant Climacoptera korshinskyi

Kipchakbaeva, A. K.; Eskalieva, B. K.; Burasheva, G. Sh.; Aisa, Haji Akber

doi:10.1007/s10600-019-02633-7

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…So, the aglycon of (6) was boucerin. 24 Thus compound ( 6 Beside the new quadranguloside A-F (1-6), known previously published compounds were isolated and identied from C. quadrangula as arabincoside C (12), arabincoside D (13), 23 cispolyoxypregnanes boucerin derivatives, isolated from the ethyl acetate fraction, russelioside C (11), russelioside B (15) and russelioside D (16), calogenin derivatives, that were identied previously from C. russeliana, 4 3b,14-dihydroxy-14b-pregn-5-en-20-one (8), 25 arabincoside A (10) and arabincoside B (18), 23 ketocalogenin derivatives, and 3b,14-dihydroxy-5a,14bpregnan-20-one (9), 26 a 5a-dihydrocalogenin derivative and 5,3 ′dihydroxy-7,4 ′ -dimethoxyavone (7), 27 chrysoeriol ( 14), 28 luteolin 4 ′ -O-b-D-neohesperidoside (17), 29 avone glycosides. These isolated compounds were identied by comparing their 1D and 2D NMR spectral data with those previously reported in the literature.…”

Section: Resultsmentioning

confidence: 99%

Quadrangulosides A–F: new pregnane glycosides from Caralluma quadrangula

et al. 2023

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Section: Resultsmentioning

confidence: 99%

Quadrangulosides A–F: new pregnane glycosides from Caralluma quadrangula

et al. 2023

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Flavones, Flavonols, Lignans, and Caffeic Acid Derivatives from Dracocephalum moldavica and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia

Jöhrer

Pérez²,

Kircher³

et al. 2022

IJMS

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Phenolic plant constituents are well known for their health-promoting and cancer chemopreventive properties, and products containing such constituents are therefore readily consumed. In the present work, we isolated 13 phenolic constituents of four different compound classes from the aerial parts of the Moldavian dragonhead, an aromatic and medicinal plant with a high diversity on secondary metabolites. All compounds were tested for their apoptotic effect on myeloma (KMS-12-PE) and AML (Molm-13) cells, with the highest activity observed for the flavone and flavonol derivatives. While diosmetin (6) exhibited the most pronounced effects on the myeloma cell line, two polymethylated flavones, namely cirsimaritin (1) and xanthomicrol (3), were particularly active against AML cells and therefore subsequently investigated for their antiproliferative effects at lower concentrations. At a concentration of 2.5 µM, cirsimaritin (1) reduced proliferation of Molm-13 cells by 72% while xanthomicrol (3) even inhibited proliferation to the extent of 84% of control. In addition, both compounds were identified as potent FLT3 inhibitors and thus display promising lead structures for further drug development. Moreover, our results confirmed the chemopreventive properties of flavonoids in general, and in particular of polymethylated flavones, which have been intensively investigated especially over the last decade.

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Polyphenols from the Plant Climacoptera korshinskyi

Cited by 2 publications

References 6 publications

Quadrangulosides A–F: new pregnane glycosides from Caralluma quadrangula

Quadrangulosides A–F: new pregnane glycosides from Caralluma quadrangula

Flavones, Flavonols, Lignans, and Caffeic Acid Derivatives from Dracocephalum moldavica and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia

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