Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein

Sun, Yiran; He, Libo; Wang, Wang; Wang, Taoyu; Wei, Hua; Li, Tingting; Wang, Li; Gao, Tingyan; Chen, Fang; Tang, Lin

doi:10.1016/j.jep.2020.113617

Cited by 9 publications

(8 citation statements)

References 51 publications

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“…Studies have shown that polyphenols can not only inhibit ROS, but also degrade Keap1, inhibit the combination of Keap1 and Nrf2, and activate the Keap1-Nrf2 signaling pathway [11]. Sun et al [28] found that polyphenols from Penthorum chinense Pursh. can directly bind to Keap1 protein and activate Nrf2 to regulate the expression of downstream antioxidant proteins, thereby reducing vascular inflammation induced by high glucose.…”

Section: Discussionmentioning

confidence: 99%

“…As shown in Figure 4A, compared with the control group, the cytoplasmic Keap1 protein expression level in the DSS group was significantly increased (p < 0.05), but GPH extracts reduced the DSSinduced increase of the cytoplasmic Keap1 protein expression, particularly at the higher dose (Figure 4A). The expressions of Nrf2 protein in cytoplasm and nucleus were decreased with DSS treatment but were significantly increased by the GPH extracts treatment in both LGPH and HGPH groups (Figure 4A,B), suggesting that the polyphenols of the GPH extracts may combine with the Keap1 to promote the nuclear transfer of Nrf2 [28].…”

Section: Gph Extracts Activated the Keap1/nrf2 Signaling Pathway And Promoted The Mrna Expression Of Nrf2 Downstream Genesmentioning

confidence: 99%

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Green Pea (Pisum sativum L.) Hull Polyphenol Extracts Ameliorate DSS-Induced Colitis through Keap1/Nrf2 Pathway and Gut Microbiota Modulation

Guo

Tsao

et al. 2021

Foods

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As a processing by-product, green pea hull (GPH) was found to be rich in phenolic components in our previous studies. In this study, UHPLC-LTQ-OrbiTrap-MS (Ultra performance liquid chromatography-linear ion trap orbitrap tandem mass spectrometry) technique was used to quantify polyphenols, and DSS (sodium dextran sulfate)-induced colitis mouse model was established to explore the effect of GPH extracts on colitis. The results showed that quercetin and its derivatives, kaempferol trihexanside and catechin and its derivatives were the main phenolic substances in the extract, reaching 2836.57, 1482.00 and 1339.91 µg quercetin/g GPH extract, respectively; GPH extracts can improved inflammatory status, repaired colonic function, regulated inflammatory factors, and restored oxidative balance in mice. Further, GPH extracts can activate Keap1-Nrf2-ARE signaling pathway, regulate downstream antioxidant protease and gut microbiota by increasing F/B value and promoting the growth of Lactobacillaceae and Lachnospiraceae, and improve the level of SCFAs (short-chain fatty acids) to relieve DSS-induced colitis in mice. Therefore, GPH may be a promising dietary resource for the treatment of ulcerative colitis.

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Section: Discussionmentioning

confidence: 99%

Section: Gph Extracts Activated the Keap1/nrf2 Signaling Pathway And Promoted The Mrna Expression Of Nrf2 Downstream Genesmentioning

confidence: 99%

Green Pea (Pisum sativum L.) Hull Polyphenol Extracts Ameliorate DSS-Induced Colitis through Keap1/Nrf2 Pathway and Gut Microbiota Modulation

Guo

Tsao

et al. 2021

Foods

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“…In recent hundred years, researchers focus in on Penthorum chinense Pursh (PCP), and PCP is a perennial herb, Chinese traditional medicine used for its hepatoprotective effects such as liver edema, infectious hepatitis, and liver injuries [ 1 , 2 ]. It is well established that PCP extract and PCP biomolecules have a range of pharmacological and health-promoting benefits, including anti-inflammatory, hepatoprotective, and antioxidant properties [ 3 – 5 ]. Hepatoprotective effect of PCP is due to cure liver damage by keeping oxygen-free radicals out and reducing inflammatory response [ 6 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

An Updated Review on Efficiency of Penthorum chinense Pursh in Traditional Uses, Toxicology, and Clinical Trials

Nabi

Ahmed

Tao

et al. 2023

BioMed Research International

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Traditional Chinese medicines (TCM) play an important role in the control and treatment of several animal diseases. Penthorum chinense Pursh (PCP) is a famous plant for its use in traditional medication practice and therapeutic effects in numerous pathological conditions. In China, PCP is utilized for both food and medication due to numerous bioactivities. PCP is widely administered in prevention and treatment of traumatic injury, edema, and liver diseases with functions of reducing swelling, support diuresis, blood stasis, and mitigation symptoms of excessive alcohol intake. Recently, PCP highlighted for research trials in various fields including pharmacology, pharmacognosy, cosmeceuticals, nutraceuticals, and pharmaceuticals due to medicinal significance with less toxicity and an effective ethnomedicine in veterinary practice. PCP contains diverse important ingredients such as flavonoids, organic acids, coumarins, lignans, polyphenols, and sterols that are important bioactive constituents of PCP exerting the therapeutic benefits and organ-protecting effects. In veterinary, PCP extract, compound, and phytochemicals/biomolecules significantly reversed the liver and kidney injuries, via antioxidation, oxidative stress, apoptosis, mitochondrial signaling pathways, and related genes. PCP water extract and compounds also proved in animal and humans’ clinical trial for their hepatoprotective, antiaging, nephroprotective, anti-inflammatory, antidiabetic, antibacterial, antiapoptotic, immune regulation, and antioxidative stress pathways. This updated review spotlighted the current information on efficiency and application of PCP by compiling and reviewing recent publications on animal research. In addition, this review discussed the toxicology, traditional use, comparative, and clinical application of PCP in veterinary practices to authenticate and find out new perspectives on the research and development of this herbal medicine.

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“…These pharmacological effects are closely related to the active components of PCPE. Flavonoids, organic acids, coumarins, lignans, polyphenols, and sterols are important bioactive constituents of PCPE, and an abundance of research has demonstrated that many extracts have significant pharmacological activities of anti-inflammation and anti-oxidation [ 13 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect of the Penthorum Chinense Pursh Extract against the CCl4-Induced Acute Liver Injury via NF-κB and p38-MAPK PATHWAYS in Dogs

Tao

Yue

et al. 2022

Animals

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Acute liver injury (ALI), manifested by acute hepatocellular damages and necrosis, is a life-threatening clinical syndrome and Penthorum Chinense Pursh (PCP) is a well-known folk medicine practiced for liver-related diseases. This study aimed to investigate the ameliorative effects of PCP extract (PCPE) on carbon tetrachloride (CCl4) induced ALI in dogs via mitogen-activated protein kinase (MAPK) and Nuclear factor κB (NF-κB) signaling pathway. Healthy dogs were induced by CCl4 and treated with different dosage regimes of PCPE for 7 days. CCl4 produced acute liver injury and induced both oxidative stress and an inflammatory response in dogs. The PCPE significantly ameliorated and improved vacuolar inflammatory lesions in liver tissues during ALI, enhanced activity of superoxide dismutase, and restored glutathione peroxidase, further significantly reducing the indices of malondialdehyde and nitric oxide in serum. Inflammatory factors (IL-1β, IL-6, and TNF-α) were declined and anti-inflammatory factors (IL-10) were increased by the application of PCPE. PCPE treatment, down-regulated the MEKK4, MKK3, p38MAPK, MSK1, and NF-κB, and upregulated the IkB mRNA levels (p < 0.01) in ALI affected dogs. In conclusion, PCPE repaired acute liver injury by improving antioxidant enzymes and by reducing oxidation products. Furthermore, the PCPE inhibited the MAPK/NF-κB signaling pathway, which resulted in anti-inflammatory and antioxidant effects on ALI-induced dogs. In the future, PCPE could be a useful ethnomedicine in veterinary clinical practices for the treatment of liver injuries or failures.

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Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein

Cited by 9 publications

References 51 publications

Green Pea (Pisum sativum L.) Hull Polyphenol Extracts Ameliorate DSS-Induced Colitis through Keap1/Nrf2 Pathway and Gut Microbiota Modulation

Green Pea (Pisum sativum L.) Hull Polyphenol Extracts Ameliorate DSS-Induced Colitis through Keap1/Nrf2 Pathway and Gut Microbiota Modulation

An Updated Review on Efficiency of Penthorum chinense Pursh in Traditional Uses, Toxicology, and Clinical Trials

Hepatoprotective Effect of the Penthorum Chinense Pursh Extract against the CCl4-Induced Acute Liver Injury via NF-κB and p38-MAPK PATHWAYS in Dogs

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