Polyphenols from Brazilian native Myrtaceae fruits and their potential health benefits against obesity and its associated complications

Donado‐Pestana, Carlos M.; Moura, Márcio Hércules Caldas; Araujo, Renata Luise de; Santiago, Gabriela de Lima; Barros, Helena Rudge de Moraes; Genovese, Maria Inês

doi:10.1016/j.cofs.2018.01.001

Cited by 61 publications

(47 citation statements)

References 37 publications

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“…On the other hand, the fruit gelatinous pulp presents a sweet and astringent taste due to its high content of sugars and acids, being very appreciated for in natura consumption or as fruit pulp preparation (Oliveira et al, 2019). The consumption of jabuticaba has been associated with diverse health benefits that are linked to its chemical composition with great polyphenol abundance (Donado-Pestana et al, 2018;Wu, Hung, Shin, Wang, & Huang, 2016).…”

Section: Introductionmentioning

confidence: 99%

Jabuticaba residues (Myrciaria jaboticaba (Vell.) Berg) are rich sources of valuable compounds with bioactive properties

et al. 2020

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Jabuticaba (Myrciaria jaboticaba (Vell.) Berg) is a Brazilian berry, very appreciated for in natura consumption. However, its epicarp is not normally consumed due to its stiffness and astringent taste, and in manufacture of products from jabuticaba fruit, it is responsible for the generation of large amounts of residues. The exploration of by-products is becoming important for the obtainment of valuable bioactive compounds for food and pharmaceutical industries. In this context, jabuticaba epicarp was studied regarding its chemical composition, namely in terms of phenolic compounds, tocopherols, and organic acids, and its bioactive properties, such as antioxidant, anti-proliferate, anti-inflammatory, and antimicrobial activities. A total of sixteen phenolic compounds, four tocopherols and six organic acids were identified in jabuticaba epicarp. Regarding bioactive properties, it showed high antioxidant activity, also presenting moderate anti-inflammatory, anti-proliferative, and antimicrobial activities. The extract did not present hepatotoxicity, confirming the possibility of its applications without toxicity issues.

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Section: Introductionmentioning

confidence: 99%

Jabuticaba residues (Myrciaria jaboticaba (Vell.) Berg) are rich sources of valuable compounds with bioactive properties

et al. 2020

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“…Today, more than 8000 plant phenolics are known and are classified into two main groups, either flavonoid or non-flavonoid compounds ( Strack and Wray 1994 ). These plant-associated substances are currently a hot topic in a wide range of research areas ( Savio et al 2016 , Berman et al 2017 , Adebooye et al 2018 , Arif et al 2018 , Donado-Pestana et al 2018 , Halake et al 2018 ). In particular, the 3,4′,5-trihydroxystilbene, known as resveratrol, has attracted a lot of research attention ( Bostanghadiri et al 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Antifungal stilbene impregnation: transport and distribution on the micron-level

et al. 2018

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The transition from the living water-transporting sapwood to heartwood involves in many tree species impregnation with extractives. These differ in amount and composition, and enhance resistance against bacteria, insects or fungi. To understand the synthesis, transport and impregnation processes new insights into the biochemical processes are needed by in-situ methods. Here we show the extractive distribution in pine (Pinus sylvestris) microsections with a high lateral resolution sampled in a non-destructive manner using Confocal Raman Microscopy. Integrating marker bands of stilbenes and lipids enables to clearly track the rapid change from sapwood to heartwood within one tree ring. The higher impregnation of the cell corner, compound middle lamella, the S3 layer and pits reveals the optimization of decay resistance on the micron-level. Furthermore, deposits with changing chemical composition are elucidated in the rays and lumen of the tracheids. The spectral signature of these deposits shows the co-location of lipids and pinosylvins with changing ratios from the living to the dead tissue. The results demonstrate that the extractive impregnation on the micro- and nano-level is optimized by a symbiotic relationship of lipids and pinosylvins to enhance the tree’s resistance and lifetime.

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“…All these health-beneficial activities were verified by various in vitro and in vivo studies and evidence from human clinical trials [18,[20][21][22]. Today, we know that these activities are attributed to the high content of vitamin C and a range of secondary metabolites such as carotenoids, phenolic compounds, terpenoids, and various undiscovered bioactive phytochemicals synthesized in camu-camu [12,[23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 84%

Bioactive Compounds of Camu-Camu (Myrciaria dubia (Kunth) McVaugh)

Castro

Maddox

Cobos³

et al. 2019

Reference Series in Phytochemistry

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Camu-camu is a shrub, native to the Amazon that thrives in areas where flooding is frequent. Genetically, the plant is characterized by a diploid genome and moderate genetic diversity. Several parts of the plant are used in traditional folk medicine to treat a variety of acute and chronic diseases. For over 50 years, the exceptionally high vitamin C content of camu-camu has attracted worldwide attention that continues today because of the recent discovery of several healthpromoting phytochemicals with corroborated biological activities (e.g., antioxidant, anti-obesity, antidiabetic). All of these beneficial attributes are well supported by in vitro and in vivo studies as well as human clinical trials. The metabolic precursors of these phytochemicals are synthesized in key metabolic pathways (i.e., the shikimate pathway, the mevalonate pathway). Of these metabolic pathways, we show details for the biosynthesis of betulinic acid, transresveratrol, and syringic acid. In conclusion, camu-camu is an exceptional plant for its ability to produce and accumulate significant amounts of a variety of health-promoting phytochemicals. Although several metabolic pathways responsible for the biosynthesis of these phytochemicals have been reconstructed based on fruit and seedling transcriptomes, detailed knowledge of the vast majority of metabolic pathways and their molecular regulatory mechanisms is lacking. Consequently, we must increase our knowledge of the metabolic processes using multi-omic approaches so that we can acquire the skills necessary to develop genetically improved varieties of camu-camu and implement biotechnological applications for the production of these bioactive phytochemicals.

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Polyphenols from Brazilian native Myrtaceae fruits and their potential health benefits against obesity and its associated complications

Cited by 61 publications

References 37 publications

Jabuticaba residues (Myrciaria jaboticaba (Vell.) Berg) are rich sources of valuable compounds with bioactive properties

Jabuticaba residues (Myrciaria jaboticaba (Vell.) Berg) are rich sources of valuable compounds with bioactive properties

Antifungal stilbene impregnation: transport and distribution on the micron-level

Bioactive Compounds of Camu-Camu (Myrciaria dubia (Kunth) McVaugh)

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