Polyphenols as NLRP3 inflammasome modulators in cardiometabolic diseases: a review of <i>in vivo</i> studies

Villalva, Marisol; Martínez-García, Juan José; Jaime, Laura; Santoyo, Susana; Pelegrín, Pablo; Pérez-Jiménez, Jara

doi:10.1039/d3fo03015f

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“…They play a pivotal role in plant defense, protecting against oxidative stress and ultraviolet radiation [ 1 ]. Additionally, they show several health-promoting bioactivities, such as the neutralization of free radicals [ 2 ] or anti-inflammatory activities [ 3 ], which eventually lead to a potential risk reduction of several diseases, such as cancer [ 4 ] or type 2 diabetes [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Differential Extraction and Preliminary Identification of Polyphenols from Ugni candollei (White Murta) Berries

Fuentes-Jorquera,

Canales,

Pérez-Correa

et al. 2024

Antioxidants

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Ugni candollei, commonly known as white murta, is a native Chilean berry with a polyphenol composition that has been underexplored. This study aimed to establish a comprehensive profile of white murta polyphenols using ultra-performance liquid chromatography electrospray ionization Orbitrap mass spectrometry (UPLC-ESI-ORBITRAP MS). Additionally, it compared the efficacy of conventional extraction methods with emerging techniques such as deep eutectic solvent (DES) extraction and hot pressurized water extraction (HPWE). The analysis tentatively identified 107 phenolic compounds (84 of them reported for the first time for this cultivar), including 25 phenolic acids, 37 anthocyanins, and 45 flavonoids. Among the prominent and previously unreported polyphenols are ellagic acid acetyl-xyloside, 3-p-coumaroylquinic acid, cyanidin 3-O-(6′-caffeoyl-glucoside, and phloretin 2′-O-xylosyl-glucoside. The study found HPWE to be a promising alternative to traditional extraction of hydroxybenzoic acids, while DES extraction was less effective across all categories. The findings reveal that white murta possesses diverse phenolic compounds, potentially linked to various biological activities.

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Section: Introductionmentioning

confidence: 99%

Differential Extraction and Preliminary Identification of Polyphenols from Ugni candollei (White Murta) Berries

Fuentes-Jorquera,

Canales,

Pérez-Correa

et al. 2024

Antioxidants

Self Cite

View full text Add to dashboard Cite

show abstract

Polyphenols as NLRP3 inflammasome modulators in cardiometabolic diseases: a review of in vivo studies

Abstract: The nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are components of the innate immune system, important to coordinate the inflammatory response. Among them, the NLRP3 could form inflammasomes, a...

Cited by 1 publication

References 103 publications

Differential Extraction and Preliminary Identification of Polyphenols from Ugni candollei (White Murta) Berries

Differential Extraction and Preliminary Identification of Polyphenols from Ugni candollei (White Murta) Berries

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