Polyphenols and their Mechanism of Action in Allergic Immune ResponseImmune Response

Abstract

Mini review article deals with the most studied group of chemical compounds -polyphenolspredominantly flavonoids in relation to their allergic immune response. There is clarified and discussed their mechanism of action as well. We emphasized on the strongest inhibitors of allergic reactions -luteolin, fisetin and apigenin, but in the second part the currently studied flavonoids have been summarized as well. The interaction of polyphenols with proteins can modulatethe process of allergic sensitization and their direct effect on allergic effector cells, such as mast cells, inhibits mediator release, resulting in the alleviation of symptoms 3. Endogenous anti-oxidant ability can limit the extent of cellular injury from free radicals during any reaction [12].

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“…Phytochemical screening Plant antioxidant and metabolite have been reported to possess antidiabetic and anti-allergic potentials. 28 Phytochemical screening of the crude ethanol extract of B. tersa leaves demonstrated the presence of different phytochemical groups such as combined reducing sugar, tannins, flavonoids, saponins, steroids, alkaloids, glycosides and terpenoids, and absence of gums, proteins and acidic compounds. Presence of these active metabolites in considerable amounts justify the possibility of anti-allergic and anti-diabetic potentials of B. tersa.…”

Polyphenol‐rich pomegranate juice reduces IgE binding to cashew nut allergens

“…In addition, it was reported that the interaction of polyphenol with protein could directly modulate the process of allergic sensitization . Moreover, it was shown that polyphenol directly interferes with T‐helper 2 activation, which inhibits allergy development . Other than possible effects on allergy alleviation, another health benefit from polyphenol is their endogenous antioxidant ability, which limits the extent of cellular injury from free radicals during the allergic reaction .…”

“…Moreover, it was shown that polyphenol directly interferes with T‐helper 2 activation, which inhibits allergy development . Other than possible effects on allergy alleviation, another health benefit from polyphenol is their endogenous antioxidant ability, which limits the extent of cellular injury from free radicals during the allergic reaction . With these health benefits, one of the potential applications of POM juice would be used as food additive for the development of less allergenic cashew products …”

Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

“…Polyphenols have a chemical structure with properties that make them the compounds with the greatest antioxidant action: o-diphenolic group, 2-3 double bond conjugated with the 4-oxo function and hydroxyl groups (OH) in positions 3 and 5 (Ruiz et al, 2009). They have antioxidant (Hua and Rong, 2016;Tarique et al, 2016), anti-inflammatory (Oliviero et al, 2018), anticarcinogenic (Niedzwiecki et al, 2016), antiallergic (Juríková et al, 2015), antibiotic (Xie et al, 2017), and immunomodulatory (Nour et al, 2018) properties.…”