Polyphenolics isolated from virgin coconut oil inhibits adjuvant induced arthritis in rats through antioxidant and anti-inflammatory action

Vysakh, A.; Ratheesh, M.; Rajmohanan, T.P.; Pramod, C; Premlal, S; Kumar, Bhumesh; Sibi, P.I.

doi:10.1016/j.intimp.2014.02.026

Cited by 92 publications

(61 citation statements)

References 23 publications

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“…MDA is a reactive molecule formed during the peroxidation of polyunsaturated fatty acids in the cell membrane [16]. In this study, an increased MDA level was observed in the paw tissue homogenate from arthritic rats, which is line with previous preclinical reports [17].…”

Section: Discussionsupporting

confidence: 91%

Alpha-mangostin attenuates oxidative stress and inflammation in adjuvant-induced arthritic rats

Xu¹,

Zhou²,

Cai³

2018

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 91%

Alpha-mangostin attenuates oxidative stress and inflammation in adjuvant-induced arthritic rats

Xu¹,

Zhou²,

Cai³

2018

Trop. J. Pharm Res

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“…Several reports from our laboratory have demonstrated that antioxidants added in the diet, such as rutine (Mendes-Junior et al 2013), lipoic acid (Queiroz et al 2012) and quercetin (Monteiro et al 2012), reduce ROS levels and restore baroreflex sensitivity in hypertensive rats. Nowadays, coconut oil has been used as dietary supplement because of its many benefits, including but not limited to weight loss (Assunção et al 2009), anti-inflammatory (Intahphuak et al 2010;Vysakh et al 2014), antibacterial (Nevin and Rajamohan, 2004), and antioxidant activity (Vysakh et al 2014). However, the combination of coconut oil supplementation and exercise training has not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Coconut oil supplementation and physical exercise improves baroreflex sensitivity and oxidative stress in hypertensive rats

Alves

Porpino

Monteiro

et al. 2015

Appl. Physiol. Nutr. Metab.

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Abstract:The hypothesis that oral supplementation with virgin coconut oil (Cocos nucifera L.) and exercise training would improve impaired baroreflex sensitivity (BRS) and reduce oxidative stress in spontaneously hypertensive rats (SHR) was tested. Adult male SHR and Wistar Kyoto rats (WKY) were divided into 5 groups: WKY + saline (n = 8); SHR + saline (n = 8); SHR + coconut oil (2 mL·day −1 , n = 8); SHR + trained (n = 8); and SHR + trained + coconut oil (n = 8). Mean arterial pressure (MAP) was recorded and BRS was tested using phenylephrine (8 g/kg, intravenous) and sodium nitroprusside (25 g·kg −1 , intravenous). Oxidative stress was measured using dihydroethidium in heart and aorta. SHR + saline, SHR + coconut oil, and SHR + trained group showed higher MAP compared with WKY + saline (175 ± 6, 148 ± 6, 147 ± 7 vs. 113 ± 2 mm Hg; p < 0.05). SHR + coconut oil, SHR + trained group, and SHR + trained + coconut oil groups presented lower MAP compared with SHR + saline group (148 ± 6, 147 ± 7, 134 ± 8 vs. 175 ± 6 mm Hg; p < 0.05). Coconut oil combined with exercise training improved BRS in SHR compared with SHR + saline group (−2.47 ± 0.3 vs. −1.39 ± 0.09 beats·min −1 ·mm Hg −1 ; p < 0.05). SHR + saline group showed higher superoxide levels when compared with WKY + saline (774 ± 31 vs. 634 ± 19 arbitrary units (AU), respectively; p < 0.05). SHR + trained + coconut oil group presented reduced oxidative stress compared with SHR + saline in heart (622 ± 16 vs. 774 ± 31 AU, p < 0.05). In aorta, coconut oil reduced oxidative stress in SHR compared with SHR + saline group (454 ± 33 vs. 689 ± 29 AU, p < 0.05). Oral supplementation with coconut oil combined with exercise training improved impaired BRS and reduced oxidative stress in SHR.Key words: virgin coconut oil, swimming, hypertension, baroreflex, antioxidant. Résumé :On vérifie l'hypothèse selon laquelle la supplémentation per os en huile de coco (Cocos nucifera L.) vierge et l'entraînement physique atténuent le dérèglement de la sensibilité du baroréflexe (« BRS ») et diminuent le stress oxydatif chez des rats spontanément hypertendus (« SHR »). On répartit des rats mâles adultes SHR et Wistar Kyoto (« WKY ») en cinq groupes : WKY + saline (n = 8); SHR + saline (n = 8); SHR + huile de coco (2 mL·jour −1 , n = 8); SHR + entraînés (n = 8) et SHR + entraînés + huile de coco (n = 8). On enregistre la pression artérielle moyenne (« MAP ») et on évalue la BRS par l'administration de phényléphrine (8 g·kg −1 , intraveineux) et de nitroprussiate de sodium (25 g·kg −1 , intraveineux). On évalue le stress oxydatif par l'administration de dihydroéthidium dans le coeur et l'aorte. Les groupes SHR + saline, SHR + huile de coco et SHR + entraînés présentent une MAP plus élevée comparativement au groupe WKY + saline (175 ± 6, 148 ± 6, 147 ± 7 vs 113 ± 2 mm Hg, p < 0,05). Les groupes SHR + huile de coco, SHR + entraînés, SHR + entraînés + huile de coco présentent une MAP plus basse comparativement au groupe SHR + saline (148 ± 6, 147 ± 7, 134 ± 8 vs 175 ± 6 mm Hg, p < 0,05). L'hui...

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“…The incredible health benefit of VCO is due to the unique type of saturated fats presents in the oil. Therefore it is considered the healthiest of all dietary oils [18]. Since its first commercial introduction by the Western establishments, VCO has caught the interest of vast majority of public and researchers alike.…”

Section: Literature Review a Virgin Coconut Oilmentioning

confidence: 99%

Virgin Coconut Oil and Its Antimicrobial Properties against Pathogenic Microorganisms: A Review

Nasir¹,

Abllah²,

Jalaludin³

et al. 2018

Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)

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Abstract-Virgin coconut oil (VCO) is the purest form of coconut oil, essentially water-clear or colourless that consists mainly of medium chain saturated fatty acids. For over many decades, the biological properties of VCO have been widely explored and investigated due to their antimicrobial potentials. The large concentration of medium chain fatty acids (MCFAs) including lauric acid (LA) and its monoglyceride form, monolaurin makes VCO effective in their mode of actions against pathogenic microorganisms. Thus, VCO could be used as a daily supplement or an alternative remedy against microbial infections. We review and discuss the current state of knowledge of VCO studies and focus on its antibacterial, antifungal, and antiviral activities aiming to unravel the underlying mechanisms of VCO inhibition of these pathogenic microorganisms.

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Polyphenolics isolated from virgin coconut oil inhibits adjuvant induced arthritis in rats through antioxidant and anti-inflammatory action

Cited by 92 publications

References 23 publications

Alpha-mangostin attenuates oxidative stress and inflammation in adjuvant-induced arthritic rats

Alpha-mangostin attenuates oxidative stress and inflammation in adjuvant-induced arthritic rats

Coconut oil supplementation and physical exercise improves baroreflex sensitivity and oxidative stress in hypertensive rats

Virgin Coconut Oil and Its Antimicrobial Properties against Pathogenic Microorganisms: A Review

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