Polyphenolic Substance of
            <i>Mytilus edulis</i>
            : Novel Adhesive Containing L-Dopa and Hydroxyproline

Waite, J. Herbert; Tanzer, Marvin L.

doi:10.1126/science.212.4498.1038

Cited by 967 publications

(695 citation statements)

References 23 publications

(6 reference statements)

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“…1e). [13][14][15] DOPA demonstrates high affinity for chemically distinct substrates via covalent or noncovalent interactions. Dopamine contains both side chain functionalities of DOPA and lysine, which resembles mussel adhesive proteins (Fig.…”

Section: Introductionmentioning

confidence: 99%

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

et al. 2013

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Multifunctional integration is an inherent characteristic for biological materials with multiscale structures. Learning from nature is an effective approach for scientists and engineers to construct multifunctional materials. In nature, mollusks (abalone), mussels, and the lotus have evolved different and optimized solutions to survive. Here, bio-inspired multifunctional graphene composite paper was fabricated in situ through the fusion of the different biological solutions from nacre (brick-and-mortar structure), mussel adhesive protein (adhesive property and reducing character), and the lotus leaf (self-cleaning effect). Owing to the special properties (self-polymerization, reduction, and adhesion), dopamine could be simultaneously used as a reducing agent for graphene oxide and as an adhesive, similar to the mortar in nacre, to crosslink the adjacent graphene. The resultant nacre-like graphene paper exhibited stable superhydrophobicity, self-cleaning, anticorrosion, and remarkable mechanical properties underwater. Multifunctional integration is an inherent characteristic for biological materials with multiscale structures.Learning from nature is an effective approach for scientists and engineers to construct multifunctional materials. In nature, mollusks (abalone), mussels, and the lotus have evolved different and optimized solutions to survive. Here, bio-inspired multifunctional graphene composite paper was fabricated in situ through the fusion of the different biological solutions from nacre (brick-and-mortar structure), mussel adhesive protein (adhesive property and reducing character), and the lotus leaf (self-cleaning effect).Owing to the special properties (self-polymerization, reduction, and adhesion), dopamine could be simultaneously used as a reducing agent for graphene oxide and as an adhesive, similar to the mortar in nacre, to crosslink the adjacent graphene. The resultant nacre-like graphene paper exhibited stable superhydrophobicity, self-cleaning, anti-corrosion, and remarkable mechanical properties underwater.

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Section: Introductionmentioning

confidence: 99%

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

et al. 2013

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“…Excess of the surface modifying ligands were removed from the isolated nanoparticles by repeated dialysis. dl-DOPA is a derivative of phenylalanine and abundantly present in the mussel adhesive protein Mytilus edulis, [41] and considered to have high affinity binding group to stabilize iron oxide nanoparticles in water [42] and physiologic buffers via M-O (M = Fe, Mn) bonding [43], [44], [45] and [46]. In addition dl-DOPA can provide the opportunity of conjugating DOTA on the surface of the nanoparticles through amide bond formation.…”

Section: Crystal Structure and Morphology Of The Nanoparticlesmentioning

confidence: 99%

The cell labeling efficacy, cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents

et al. 2011

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/npsi/ctrl?action=rtdoc&an=19739632&lang=en http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?action=rtdoc&an=19739632&lang=fr READ THESE TERMS AND CONDITIONS CAREFULLY BEFORE USING THIS WEBSITE.http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=en Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous n'arrivez pas à les repérer, communiquez avec nous à PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. Questions?Contact the NRC Publications Archive team at PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. If you wish to email the authors directly, please see the first page of the publication for their contact information. NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://doi.org/10.1016/j.biomaterials.2010.10.013 Biomaterials, 32, 4, pp. 1167Biomaterials, 32, 4, pp. -1176Biomaterials, 32, 4, pp. , 2010 The cell labeling efficacy, cytotoxicity and relaxivity of copperactivated MRI/PET imaging contrast agents AbstractA new class of nanoparticle-based dual-modality positron emission tomography/magnetic resonance imaging (PET/MRI) contrast agents has been developed. The probe consists of a superparamagnetic iron oxide (SPIO) or manganese oxide core coated with 3,4-dihydroxy-d,l-phenylalanine (dl-DOPA). The chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was conjugated to DOPA termini. The DOTA modified nanoparticles allow chelation of copper for PET imaging. These surface functionalized nanoparticle-based probes have been characterized by various analytical techniques. The cell-labeling efficacy, cytotoxicity and relaxivity of these nanoparticles have been evaluated and compared with the same properties of one of the most commonly utilized MRI contrast agents, Feridex ® . Evidently, this new nanoparticle has a great potential for use in cell tracking with MRI and PET in the absence of transfecting agent. It is noteworthy that there is a sharp increase in r 2 relaxivity of these nanoparticles on coordination with Cu 2+ ions. Thus these iron oxide nanoparticles can also be explored as the smart magnetic resonance (MR) sensor for the detection of micromolar changes in copper concentration for neurodegenerative diseases such as Alzheimer's disease, Menkes and Wilson's diseases, amyotrophic lateral sclerosis and prion diseases.

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“…Hydroxylation (e.g., tyrosine to DOPA) and phosphorylation (e.g., serine to phosphoserine) are post‐translational modifications commonly used by marine organisms to modify the adhesive properties of their cement proteins 7, 8, 27, 28, 29. As previously mentioned, barnacle cement does not contain DOPA;10, 11, 12 however, Gohad et al and Dickinson et al demonstrated that cyprid cement and the barnacle cementing apparatus are phosphorylated, respectively 14, 30.…”

mentioning

confidence: 99%

Acorn Barnacles Secrete Phase‐Separating Fluid to Clear Surfaces Ahead of Cement Deposition

et al. 2018

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Marine macrofoulers (e.g., barnacles, tubeworms, mussels) create underwater adhesives capable of attaching themselves to almost any material. The difficulty in removing these organisms frustrates maritime and oceanographic communities, and fascinates biomedical and industrial communities seeking synthetic adhesives that cure and hold steadfast in aqueous environments. Protein analysis can reveal the chemical composition of natural adhesives; however, developing synthetic analogs that mimic their performance remains a challenge due to an incomplete understanding of adhesion processes. Here, it is shown that acorn barnacles (Amphibalanus (=Balanus) amphitrite) secrete a phase‐separating fluid ahead of growth and cement deposition. This mixture consists of a phenolic laden gelatinous phase that presents a phase rich in lipids and reactive oxygen species at the seawater interface. Nearby biofilms rapidly oxidize and lift off the surface as the secretion advances. While phenolic chemistries are ubiquitous to arthropod adhesives and cuticles, the findings demonstrate that A. amphitrite uses these chemistries in a complex surface‐cleaning fluid, at a substantially higher relative abundance than in its adhesive. The discovery of this critical step in underwater adhesion represents a missing link between natural and synthetic adhesives, and provides new directions for the development of environmentally friendly biofouling solutions.

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Polyphenolic Substance of Mytilus edulis : Novel Adhesive Containing L-Dopa and Hydroxyproline

Cited by 967 publications

References 23 publications

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

The cell labeling efficacy, cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents

Acorn Barnacles Secrete Phase‐Separating Fluid to Clear Surfaces Ahead of Cement Deposition

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