Polyphenol supplementation inhibits physiological increase of prostaglandin E2 during reproductive period – A randomized clinical trial

Zílio, Ana Maria Arregui; Zielinsky, Paulo; Vian, Izabele; Lampert, Kenya Venusa; Raupp, D.; Weschenfelder, Camila; Brum, Cristiano; Arnt, A.; Piccoli, Antônio; Nicoloso, Luiz Henrique Soares; Schaun, Maximiliano Isoppo; Markoski, Melissa Medeiros

doi:10.1016/j.plefa.2017.04.001

Cited by 5 publications

(5 citation statements)

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“…The mechanism of DA constriction induced by polyphenols is different from DA constriction induced by drugs. In addition to reducing maternal prostaglandin E2 (PGE2) by inhibiting COX1 and COX2, polyphenols also participate in antioxidant reactions and indirectly cause maternal PGE2 reduction ( 17 , 28 ). Another possible reason is that myocardial strain parameters are more sensitive than conventional echocardiography.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Function Assessment in Fetuses With Ductus Arteriosus Constriction: A Two-Dimensional Echocardiography and FetalHQ Study

Liu

et al. 2022

Front. Cardiovasc. Med.

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BackgroundFetal ductal constriction (DC) is associated with excessive polyphenol-rich food (PRF) consumption during pregnancy. However, the effect of this hemodynamic change on fetal cardiac function still needs to be elucidated. Therefore, this study aimed to evaluate the cardiac function of fetuses with PRF-related DC and to describe serial observations of cardiac function changes.MethodsWe compared the traditional echocardiographic indices, including morphological, hemodynamic, and functional parameters, between study fetuses and controls. For global and segmental deformation analysis of the left and right ventricles, fetalHQ with the speckle-tracking technique was used to calculate sphericity index (SI), global longitudinal strain (GLS), fractional shortening (FS), fractional area change (FAC), etc. In addition, follow-up data were compared with the generalized linear model.ResultsA total of 60 DC fetuses and 60 gestational-matched controls were enrolled in our study, with 20 DC fetuses undertaking a follow-up echocardiogram after 2–3 weeks. Compared with controls, there was a distinct decrease in right ventricular GLS (RVGLS) (−13.39 ± 3.77 vs. −21.59 ± 2.51, p < 0.001), RVFAC (22.20 ± 9.56 vs. 36.01 ± 4.84, p < 0.001), left ventricular GLS (LVGLS) (−19.52 ± 3.24 vs. −23.81 ± 2.01 p < 0.001), and LVFAC (39.64 ± 7.32 vs. 44.89 ± 4.91, p = 0.004). For 24-segment FS analysis, DC fetuses showed lower FS in left ventricular (LV) segments 18–24, with no difference in LV segments 1–17. Right ventricular (RV) FS in segments 4–23 was also reduced in the DC group. The 24-segment SI analysis indicated significantly lower SI in DC than those in controls for LV segments 1–14 and RV segments 19–24. We found that the pulsatility index (PI) of ductus arteriosus (DA) was an independent variable for RVGLS (β = −0.29, p = 0.04). In 20 DC fetuses with follow-up echocardiograms, no obvious difference in myocardial deformation was found between the initial examination and follow-up data.ConclusionLeft and right ventricular performances were both impaired in DC fetuses, along with a series of morphological and hemodynamic changes. Although the state of DA constriction improved on second examinations, cardiac function was not completely restored.

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Section: Discussionmentioning

confidence: 99%

Cardiac Function Assessment in Fetuses With Ductus Arteriosus Constriction: A Two-Dimensional Echocardiography and FetalHQ Study

Liu

et al. 2022

Front. Cardiovasc. Med.

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“…Polyphenols have a similar effect to that of NSAIDs in inhibiting COX, thus decreasing PG synthesis. In a recent study, supplementation with polyphenol capsules in women of childbearing age inhibited the increase in markers of inflammation and oxidative stress. Experimental studies showed that maternal consumption of polyphenols in the third gestational trimester changes the dynamics of fetal DA, which may result in ductal constriction.…”

Section: Discussionmentioning

confidence: 99%

Increase of prostaglandin E2 in the reversal of fetal ductal constriction after polyphenol restriction

Vian¹,

Zielinsky

Zílio³

et al. 2018

Ultrasound in Obstet & Gyne

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“…Later, 1647 other studies were excluded since they had not RCT design (n 1222), did not evaluate the effect of grape products as interventions (n 381) and they were animal studies (n 7), review/meta-analysis studies (n 35), and in Persian (n 2). Full texts of the remaining articles were reviewed and twenty-five papers were excluded since: they did not have control group (80,81) , did not report the amount of CRP levels (82)(83)(84)(85)(86)(87)(88)(89)(90)(91)(92)(93) , contained alcoholic beverage without polyphenols (94,95) , assessed the effect of grape product along with a diet (96)(97)(98) or with other products (99)(100)(101)(102)(103) , its full text was not available although an email that was sent to the corresponding author (104) . Therefore, seventeen studies were included in our systematic review and meta-analysis (Fig.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials

Sarkhosh-Khorasani

Hosseinzadeh

2020

Br J Nutr

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Although grape polyphenols can decrease chronic inflammations, their effect on C-reactive protein (CRP) levels is still controversial. So, this meta-analysis was conducted to investigate the effect of grape products containing polyphenols on CRP concentrations. In order to collect the relevant randomized controlled trials (RCTs), the data bases of PubMed, Scopus, Web of Science, and Google Scholar were searched up to March 30, 2020. The random-effects model, standardized mean difference, and 95% confidence interval were applied in data analysis. Meta-analysis was conducted over 17 eligible RCTs containing a total of 668 participants. The study registration number is CRD42018110169. Based on the results, grape products containing polyphenol decreased the CRP levels significantly (SMD = -0.229; 95% CI: -0.41, -0.05; P = 0.013). The sensitivity analysis was performed by removing each individual study and the results did not change. According to the subgroup analysis, higher doses of grape polyphenols (˃ 500 mg/d) and longer intervention periods (≥ 12 wk) had significant effects on CRP levels. Furthermore, grape polyphenols significantly reduced the CRP levels in patients with a clinical condition. In the same vein, grape seed extract and other grape products, such as grape extract, juice, and raisin, decreased the CRP levels significantly. According to the meta-regression results, the CRP level depends on the dose and duration of the grape polyphenols supplementation. Based on the findings, grape products containing polyphenols had a significant effect on CRP levels. Further well-designed and long-term clinical trials are highly recommended to achieve more comprehensive and accurate results.

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Polyphenol supplementation inhibits physiological increase of prostaglandin E2 during reproductive period – A randomized clinical trial

Cited by 5 publications

References 21 publications

Cardiac Function Assessment in Fetuses With Ductus Arteriosus Constriction: A Two-Dimensional Echocardiography and FetalHQ Study

Cardiac Function Assessment in Fetuses With Ductus Arteriosus Constriction: A Two-Dimensional Echocardiography and FetalHQ Study

Increase of prostaglandin E2 in the reversal of fetal ductal constriction after polyphenol restriction

The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials

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