Polyphenol-rich extract and fractions of Terminalia phaeocarpa Eichler possess hypoglycemic effect, reduce the release of cytokines, and inhibit lipase, α-glucosidase, and α-amilase enzymes

Gomes, José Hugo de Sousa; Mbiakop, Ulrich C.; Oliveira, Renata Barbosa de; Stehmann, João Renato; Pádua, Rodrigo Maia de; Côrtes, Steyner F.; Braga, Fernão Castro

doi:10.1016/j.jep.2021.113847

Cited by 13 publications

(8 citation statements)

References 48 publications

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“…One study showed that polyphenolic extracts from Indian ginger at 6.25 µg/mL increased insulin stimulated glucose uptake in C2C12 cells by inhibiting α-amylase and α-glucosidase, decreasing glycation, and increasing GLUT4 expression [29]. Similar results were found in a recent study of the effects of 30 and 90 µg/mL of the polyphenol-rich Terminalia phaeocarpa, which was found to inhibit pancreatic lipase, α-amylase, and α-glucosidase, TNF-α, IL-1β, and CCL-2 expression in LPS-treated THP-1 cells [30]. A study by Vlavcheski et al also showed how 5 µM rosmarinic acid increased glucose uptake to levels comparable to insulin and metformin treatments through AMPK phosphorylation in L6 rat muscle cells [31].…”

Section: Diabetessupporting

confidence: 82%

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

et al. 2021

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Drugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.

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Section: Diabetessupporting

confidence: 82%

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

et al. 2021

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“…Furthermore, other South American species like Clusia latipes Planch. & Triana (Clusiaceae) [28] and Terminalia phaeocarpa Eichler (Combretaceae) [29] shown to possess inhibitory activity on -glucosidases, which was reported as not significant in the Mexican species in this study. However, even though both plants presented a modest inhibition of -glucosidases (around 25%), this mechanism could contribute to the hypoglycemic effect in the postprandial state in a synergistic way, namely the possible reduction of postprandial hyperglycemia by these plants could be mainly due to other mechanisms, such as insulin secretion, improvement of insulin function, and blocking of intestinal absorption, rather than inhibition of carbohydrate breakdown.…”

Section: Discussionmentioning

confidence: 49%

Hypoglycemic Effect of Two Mexican Medicinal Plants

Andrade‐Cetto

Espinoza-Hernández

Mata-Torres

et al. 2021

Plants

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Type 2 diabetes is a worldwide prevalent disease that is due to a progressive loss of adequate β-cell insulin secretion, frequently against a background of insulin resistance. In Mexican traditional medicine, the therapeutic use of hypoglycemic plants to control the disease is a common practice among type 2 diabetic patients. In the present work, we examined the traditional use of the aerial parts of Eryngium longifolium and the rhizome of Alsophila firma, consumed by people use over the day (in fasting state) to control their blood glucose levels, therefore, we aimed to assess the acute hypoglycemic effect of both plants. First, basic phytochemical profiles of both plants were determined and, subsequently, acute toxicity tests were carried out. Then, in vivo hypoglycemic tests were performed in streptozotocin-nicotinamide (STZ-NA) induced hyperglycemic Wistar rats and finally the effect of the plants on three enzymes involved in glucose metabolism was assayed in vitro. Through HPLC-DAD chromatography, caffeic acid, chlorogenic acid, rosmarinic acid, isoflavones, and glycosylated flavonoids were identified in E. longifolium, while the possible presence of flavanones or dihydroflavonols was reported in A. firma. Both plants exhibited a statistically significant hypoglycemic effect, without a dose-dependent effect. Furthermore, they inhibited glucose 6-phosphatase and fructose 1,6-bisphosphatase in in vitro assays, which could be associated with the hypoglycemic effect in vivo. Thus, this study confirmed for the first time the traditional use of the aerial part of E. longifolium and the rhizome of A. firma as hypoglycemic agents in a hyperglycemic animal model. In addition, it was concluded that their ability to regulate hyperglycemia could involve the inhibition of hepatic glucose output, which mainly controls glucose levels in the fasting state.

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“…[38] By using UPLC-ESI-MS/MS analyses, we recently identified 38 phenolic compounds in the ethanol extract of T. phaeocarpa leaves herein tested. [39] The identified constituents were mainly phenolic acids, ellagitannins and flavonoids, classes of compounds widely distributed in Terminalia species. Some of them have had their antiviral activity reported against different viruses, like the hydrolysable tannins casuarinin (from Terminalia arjuna) and chebulagic acid.…”

Section: Resultsmentioning

confidence: 98%

“…The Brazilian endemic species T. phaeocarpa is traditionally used as antidiabetic and anti‐inflammatory [38] . By using UPLC‐ESI‐MS/MS analyses, we recently identified 38 phenolic compounds in the ethanol extract of T. phaeocarpa leaves herein tested [39] . The identified constituents were mainly phenolic acids, ellagitannins and flavonoids, classes of compounds widely distributed in Terminalia species.…”

Section: Resultsmentioning

confidence: 99%

Anti‐Zika Virus Activity of Plant Extracts Containing Polyphenols and Triterpenes on Vero CCL‐81 and Human Neuroblastoma SH‐SY5Y Cells

Pereira

Costa

Gomes

et al. 2022

Chemistry & Biodiversity

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Zika virus (ZIKV) infection is a global threat associated to neurological disorders in adults and microcephaly in children born to infected mothers. No vaccine or drug is available against ZIKV. We herein report the anti‐ZIKV activity of 36 plant extracts containing polyphenols and/or triterpenes. ZIKV‐infected Vero CCL‐81 cells were treated with samples at non‐cytotoxic concentrations, determined by MTT and LDH assays. One third of the extracts elicited concentration‐dependent anti‐ZIKV effect, with viral loads reduction from 0.4 to 3.8 log units. The 12 active extracts were tested on ZIKV‐infected SH‐SY5Y cells and significant reductions of viral loads (in log units) were induced by Maytenus ilicifolia (4.5 log), Terminalia phaeocarpa (3.7 log), Maytenus rigida (1.7 log) and Echinodorus grandiflorus (1.7 log) extracts. Median cytotoxic concentration (CC50) of these extracts in Vero cells were higher than in SH‐SY5Y lineage. M. ilicifolia (IC50=16.8±10.3 μg/mL, SI=3.4) and T. phaeocarpa (IC50=22.0±6.8 μg/mL, SI=4.8) were the most active extracts. UPLC‐ESI‐MS/MS analysis of M. ilicifolia extract led to the identification of 7 triterpenes, of which lupeol and a mixture of friedelin/friedelinol showed no activity against ZIKV. The composition of T. phaeocarpa extract comprises phenolic acids, ellagitannins and flavonoids, as recently reported by us. In conclusion, the anti‐ZIKV activity of 12 plant extracts is here described for the first time and polyphenols and triterpenes were identified as the probable bioactive constituents of T. phaeocarpa and M. ilicifolia, respectively.

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Polyphenol-rich extract and fractions of Terminalia phaeocarpa Eichler possess hypoglycemic effect, reduce the release of cytokines, and inhibit lipase, α-glucosidase, and α-amilase enzymes

Cited by 13 publications

References 48 publications

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

Hypoglycemic Effect of Two Mexican Medicinal Plants

Anti‐Zika Virus Activity of Plant Extracts Containing Polyphenols and Triterpenes on Vero CCL‐81 and Human Neuroblastoma SH‐SY5Y Cells

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