Polyphenol Profile, Antioxidant and Hypoglycemic Activity of Acalypha hispida Leaf Extract

Alfarisi, Hamzah; Diah, S. Sa; Wresdiyati, Tutik

doi:10.36468/pharmaceutical-sciences.649

Cited by 6 publications

(14 citation statements)

References 41 publications

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“…Polyphenols are bioactive compounds that act as free radical scavengers in the body (Gelen et al, 2021). Our study has previously identified the polyphenols content in the Acalypha hispida leaves extract (Alfarisi et al, 2020a). There are 17 types of flavonoids and 5 types of phenolic acid in the A. hispida leaves extract with antihyperglycemic and antioxidant properties (Alfarisi et al, 2020a).…”

Section: Introductionmentioning

confidence: 93%

“…Our study has previously identified the polyphenols content in the Acalypha hispida leaves extract (Alfarisi et al, 2020a). There are 17 types of flavonoids and 5 types of phenolic acid in the A. hispida leaves extract with antihyperglycemic and antioxidant properties (Alfarisi et al, 2020a). However, there are several limitations to using herbal medicines in crude extracts, mainly through oral administration, which are high doses and poor absorption of bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

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Nanoextract of Acalypha hispida leaves increases antioxidant defense and suppresses microstructure damage in liver and kidney of diabetic rats

Alfarisi¹,

Wresdiyati²,

Sa’diah³

et al. 2022

j app pharm sci

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Nanotechnology has rapidly grown in various research fields, including phytomedicine to treat oxidative stress in diabetes. This study aimed to evaluate the effect of the nanoextract of Acalypha hispida leaves on antioxidant defense and microstructure of the liver and kidney in diabetic rats. A total of 24 rats were divided into 6 groups (n = 4): normal rats, diabetic rats, and diabetic rats treated with metformin at 88 mg/kg, extract at 300 mg/kg, and nanoextract at 30 and 60 mg/kg body weight (BW). BW, blood biochemistry (alanine aminotransferase, aspartate aminotransferase, urea, and creatinine), total superoxide dismutase (SOD), catalase (Cat), and malondialdehyde (MDA) were evaluated. Histomorphological and immunohistochemical (Cu, Zn-SOD) analyses were observed in the liver and kidney. The extract and nanoextract of A. hispida improved blood biochemistry in diabetic rats. Both decreased MDA level and increased total SOD and Cat activity in the liver and kidney of diabetic rats. Cu, Zn-SOD contents of the liver and kidney in the extract and nanoextract-treated diabetic were higher than in the diabetic control. The nanoextract at 60 mg/kg BW showed the best effect in suppressing microstructure damage to the liver and kidney. The study concluded that the nanoextract of A. hispida leaves increased antioxidant defense and suppressed microstructure damage in the liver and kidney of diabetic rats.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Nanoextract of Acalypha hispida leaves increases antioxidant defense and suppresses microstructure damage in liver and kidney of diabetic rats

Alfarisi¹,

Wresdiyati²,

Sa’diah³

et al. 2022

j app pharm sci

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show abstract

“…5 . Ethanol extract of Acalypha hispida shows anti-inflammatory and anti-oxidant activity 7 . Its leaf extract contain phenols found to be active against Rhizopussp, Penicilliumsp, Sclerotiumrolfsii, Fusariumsp and Aspergillus niger 7 .…”

Section: Phyto Constituentsmentioning

confidence: 99%

“…The plant has been reported to have various pharmacological activities such as anti-microbial and cytotoxic activities 8 , anti-oxidant & hypoglycemic 7 , trypanocidal effect 9 , anti-fungal activity 5 , anti-inflammatory 10 , free radical scavenging activities 12 , phytochemical constituents 3 , in-vitro anti-oxidant & anti-inflammatory potential 4 , anti-microbial 6 , toxicity activities etc.…”

Section: Phyto Constituentsmentioning

confidence: 99%

Traditional uses, phytochemistry and pharmacology of Acalypha hispida burm: A systematic review

P¹,

RAJAN²,

M³

et al. 2022

World J. Bio. Pharm. Health Sci.

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Acalypha hispida belongs to the family Euphorbiaceae, it is a tropical shrub and an annual plant commonly known as ‘chenille plant’, ‘Red hot cat tail. It is native to the south pacific, new guinea, the malay archipelago and other islands in the east indies. It is commonly used as an ornamental plant in the garden and house. Traditionally the leaves are laxative, diuretic and used in the treatment of leprosy and gonorrhea. Different part of the plant is also used in infectious diarrhoea, pulmonary problems and as an expectorant in asthma. Phytochemical studies revealed the presence of many compounds like alkaloids, tannins, saponins, flavonoids, glycosides, phenols, steroids, hydroxyanthraquinones etc. Acalypha hispida have been reported to have various pharmacological activities such as anti-inflammatory, anti-oxidant, hypoglycemic, anti-microbial, anti-fungal activity, trypanocidal effect, cytotoxic activities etc. The current reviews of Acalypha hispida summarizes information about the pharmacology, chemical constituents, biological activities and toxicological study. This review summarizes the research work carried out on this plant to provide updated information for future work.

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“…For the most part, scholars have focused on studying crude extracts (organic or aqueous), although a small number have also looked at pure substances themselves. It was shown that the vast majority of plant extracts and pure chemicals were effective against either α -amylase or α -glucosidase [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Alpha-Amylase Enzyme Assay of Hydroalcoholic Polyherbal Extract: Proof of Concept for the Development of Polyherbal Teabag Formulation for the Treatment of Diabetes

Quazi¹,

Patwekar

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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For the treatment and maintenance of postprandial blood glucose increases (i.e., diabetes mellitus), alpha (α)-amylase is a well-known therapeutic target. In this paper, we report an initial exploration of the work, i.e., in vitro alpha-amylase activity of the hydroalcoholic polyherbal extract of the selected plants. After drying, the plant material is ground individually, and at least 100 gm of the crude powder is prepared from each plant. 100 gm of each plant was combined, and a total of 500 gm of the crude powder (Ichnocarpus frutescens (100 gm) + Ficus dalhousie (100 gm) + Crateva magna (100 gm) + Alpinia galangal (100 gm) + Swertia chirata (100 gm)) was prepared to carry out the extraction. This obtained extract was subjected to preliminary phytochemical screening and in vitro alpha-amylase activity. At 16 mg/mL, acarbose displayed 78.40 ± 0.36% inhibition, whereas the extract exhibited 72.96 ± 0.70% inhibition, which is significantly comparable. The IC50 value of acarbose was 12.9 ± 1.12, whereas the extract exhibited 13.31 ± 1.12 mg/mL. The extract possesses numerous classes of chemicals such as alkaloids, glycosides, tannins, polyphenols, and terpenoids, which can contribute to the antidiabetic activity through alpha-amylase inhibition. This was an initial exploration of the work as a proof of concept for the development of polyherbal tea bag formulation for the treatment of diabetes. In the future, we are aiming to investigate the effectiveness of polyherbal tea bags in the treatment of diabetes using more in vitro and in vivo models. From the present investigation, we have concluded that this extract can be used for the treatment of diabetes.

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Polyphenol Profile, Antioxidant and Hypoglycemic Activity of Acalypha hispida Leaf Extract

Cited by 6 publications

References 41 publications

Nanoextract of Acalypha hispida leaves increases antioxidant defense and suppresses microstructure damage in liver and kidney of diabetic rats

Nanoextract of Acalypha hispida leaves increases antioxidant defense and suppresses microstructure damage in liver and kidney of diabetic rats

Traditional uses, phytochemistry and pharmacology of Acalypha hispida burm: A systematic review

In Vitro Alpha-Amylase Enzyme Assay of Hydroalcoholic Polyherbal Extract: Proof of Concept for the Development of Polyherbal Teabag Formulation for the Treatment of Diabetes

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