Polyphenol Extract of Moringa Oleifera Leaves Alleviates Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice

Zhang, Yunjuan; Lei, Peng; Li, Wenyun; Dai, Tianyi; Nie, Long; Xie, Jing; Ai, Yu; Li, Lingfei; Yang, Tian; Sheng, Jun

doi:10.1155/2020/6295402

Cited by 20 publications

(11 citation statements)

References 33 publications

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“…Therefore, effective treatment strategies for IBD, especially using dietary interventions with low cost and no side effects, are needed to be developed (30). As compared to the studies, concerning the effects of bioactive nutrients, such as multiple sources of polyphenols (31)(32)(33), the studies, investigating the relationship between macronutrients in a daily diet and IBD, are relatively limited. Lipid is an essential macronutrient for humans and animals.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effects of Long-Term Intake of Plant Oils With Different Linoleic Acid/Alpha-Linolenic Acid Ratios on Acute Colitis Mouse Model

et al. 2022

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ObjectiveTo investigate the preventive effects of plant oils with different linoleic acid/alpha-linolenic acid (LA/ALA) ratios against colitis symptoms, and dysbiosis of gut microbiota in acute colitis mouse model.MethodsSixty male C57BL/6 mice were assigned into six groups (n = 10): three groups were fed low-fat diets with low, medium, and high LA/ALA ratios; and three groups were fed with high-fat diets with low, medium, and high LA/ALA ratios. After 3 months of diet, the mice were exposed to dextran sodium sulfate solution to induce acute colitis. The severity of colitis was estimated by disease activity index (DAI) and histopathological examination. 16S rRNA gene sequencing was used for the analysis of gut microbiota.ResultsPlant oils with a lower LA/ALA ratio showed higher alleviating effects on the symptoms of colitis, which were accompanied by the better prebiotic characteristics manifested as effectively inhibiting the abnormal expansion of phylum Proteobacteria and genus Escherichia-Shigella in the gut microbiota of colitis mouse models.ConclusionA potential IBD prevention strategy of reducing the LA/ALA ratio in the daily consumed plant oils was proposed in this study. Furthermore, based on the optimized LA/ALA ratio, this preventive effect might not be weakened by the high intake of plant oils.

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Section: Discussionmentioning

confidence: 99%

Preventive Effects of Long-Term Intake of Plant Oils With Different Linoleic Acid/Alpha-Linolenic Acid Ratios on Acute Colitis Mouse Model

et al. 2022

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“…is an essential herb used in the treatment of various diseases such as inflammation, diabetes, and high blood pressure. Quantities of 50 mg/kg and 200 mg/kg of M. oleifera polyphenol extract, rich in quercetin, kaempferitrin, chlorogenic acid, luteolin, and rutin, has been found to alleviate the symptoms of dextran sulfate sodium-induced colitis by the downregulation of NF-κB p65 and p-IκBα [86].…”

Section: Digestive Diseasesmentioning

confidence: 99%

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

et al. 2021

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Drugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.

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“…In the past, accumulating evidences suggested that polyphenols are potential sources of alternative medications to treat the oxidative stress and inflammation associated with degenerative diseases, such as diabetes mellitus (DM), rheumatoid arthritis (RA), and cardiovascular disease [9]. More importantly, a recent study showed that polyphenol extract of Moringa oleifera containing astragalin, chlorogenic acid, isoquercitrin, kaempferitrin, luteolin, quercetin, and rutin could alleviate colonic inflammation in DSS-treated mice associated with the NF-κB signaling pathway [10], indicating the anti-inflammatory potential of polyphenols on intestinal diseases. The small intestine plays a key role in the digestion and absorption of nutrients, including carbohydrates, proteins, and lipids.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

Wang

Yang

2022

IJMS

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TLR4/NF-κB is a key inflammatory signaling transduction pathway, closely involved in cell differentiation, proliferation, apoptosis, and pro-inflammatory response. Toll like receptor 4 (TLR4), the first mammalian TLR to be characterized, is the innate immune receptor that plays a key role in inflammatory signal transductions. Nuclear factor kappa B (NF-κB), the TLR4 downstream, is the key to accounting for the expression of multiple genes involved in inflammatory responses, such as pro-inflammatory cytokines. Inflammatory bowel disease (IBD) in humans is a chronic inflammatory disease with high incidence and prevalence worldwide. Targeting the TLR4/NF-κB signaling pathway might be an effective strategy to alleviate intestinal inflammation. Polyphenol phytochemicals have shown noticeable alleviative effects by acting on the TLR4/NF-κB signaling pathway in intestinal inflammation. This review summarizes the pharmacological effects of more than 20 kinds of polyphenols on intestinal inflammation via targeting the TLR4/NF-κB signaling pathway. We expected that polyphenol phytochemicals targeting the TLR4/NF-κB signaling pathway might be an effective approach to treat IBD in future clinical research applications.

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Polyphenol Extract of Moringa Oleifera Leaves Alleviates Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice

Cited by 20 publications

References 33 publications

Preventive Effects of Long-Term Intake of Plant Oils With Different Linoleic Acid/Alpha-Linolenic Acid Ratios on Acute Colitis Mouse Model

Preventive Effects of Long-Term Intake of Plant Oils With Different Linoleic Acid/Alpha-Linolenic Acid Ratios on Acute Colitis Mouse Model

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

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