Polypharmacy: correlations with sex, age and drug regimen

Bjerrum, Lars; Søgaard, Jes; Hallas, Jesper; Kragstrup, Jakob

doi:10.1007/s002280050445

Cited by 207 publications

(197 citation statements)

References 21 publications

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“…1 The presence of cognitive impairment was determined by means of the MMSE, 3 adapted for Brazil. In this, instead of the season of the year, individuals are asked about the period of the day; in the questions about spatial orientation, the district, address and room in the house replace respectively the county, hospital and fl oor.…”

Section: Methodsmentioning

confidence: 99%

Influência da renda na associação entre disfunção cognitiva e polifarmácia: Projeto Bambuí

et al. 2008

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OBJECTIVE:To evaluate the prevalence of polypharmacy and the infl uence of income on the association between medication use and cognitive impairment among elderly people. METHODS:Out of the 1,606 baseline members of the Bambuí cohort of elderly people, which started in 1997, 1,554 took part in the study. The MiniMental State Examination was applied to all the participants. The association between cognitive impairment and polypharmacy was tested by means of multivariate ordinal regression, performed for the whole population and for each of the income strata. RESULTS:The prevalence of polypharmacy (two or more medications consumed) was 70.4% and the number of medications used presented an independent negative association with cognitive impairment (OR=0.72; 95% CI: 0.55;0.95). When this was stratifi ed according to personal income (<2 minimum monthly salaries versus > 2 minimum monthly salaries), a negative association was observed between medication use and cognitive impairment among elderly people with lower income (OR=0.64; 95% CI: 0.48;0.86), but not among those with higher income (OR=1.74; 95% CI: 0.81;3.74). CONCLUSIONS:With regard to the association between cognitive impairment and number of medications consumed, the results indicate social inequality in the use of medications. It is possible that these elderly people are not consuming the medicines needed for appropriate treatment of their health problems.

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Section: Methodsmentioning

confidence: 99%

Influência da renda na associação entre disfunção cognitiva e polifarmácia: Projeto Bambuí

et al. 2008

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“…24 A Danish study of prescription data found that two thirds of all prescription medication users older than 70 years used 2 or more prescription medications. 25 And a 1998…”

Section: Examination Of Multiple Medication Use Among Tricare Beneficmentioning

confidence: 99%

Examination of Multiple Medication Use Among TRICARE Beneficiaries Aged 65 Years and Older

Linton¹,

Garber²,

Fagan³

et al. 2007

JMCP

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he simultaneous use of multiple prescription medications has been repeatedly identified as an area of concern, particularly among our nation' s older adults.1 While older adults typically require more medications to manage multiple comorbidities, disease-centric prescribing, reduced organ function, and higher use of over-the-counter products among older adults complicates a prescriber' s or pharmacist' s ability to anticipate how concomitant use of multiple medications is likely to affect the underlying mechanisms by which each functions as prescribed.2,3 While risks associated with use of specific medications or combinations of medications among older patients have been well characterized, 4-6 assimilation of this information into prescribing practice is not evident. Perhaps many prescribers simply cannot consider all the medications their patients are already taking when they prescribe a new medication. 7 The likelihood of patients becoming confused by or noncompliant with their own drug regimen also increases with the size of their medication list.2 Too often, a critical review of a patient' s medication use is not conducted until after an adverse drug event occurs and has been recognized as such. 8Many of the studies examining multiple medication use by older adults to date have focused on non-U.S. populations, whereas studies on U.S. populations have focused more on inappropriate prescribing and medication-specific risks. Among the available literature, there is general agreement that multiple prescription medication use is more prevalent among older adults, women, and cardiovascular patients, but estimates vary widely and comparison of findings is complicated by the absence of a standard time period over which medication use ABSTRACT BACKGROUND: The simultaneous use of multiple prescription medications has been associated with an increased risk of adverse drug events and other drug-related complications, especially in the elderly.OBJECTIVE: To quantify the prevalence of use of multiple medications among a sample of Department of Defense (DoD) health care beneficiaries, aged 65 years and older, who used their TRICARE (military health care services) benefit to obtain prescription medication.METHODS: Outpatient pharmacy fill records were analyzed for a 10% random sample of 1.27 million TRICARE beneficiaries aged 65 years and older who obtained 1 or more prescription medications in the 90-day period from (P <0.001). The prevalence of multiple drug use peaked among beneficiaries aged 80 to 84 years. Cardiovascular drugs, central nervous system agents, and hormones and synthetic substitutes were the 3 most common therapeutic categories used by 77%, 48%, and 42% of beneficiaries, respectively.CONCLUSION: This baseline analysis documented the common use of multiple medications among TRICARE beneficiaries. The DoD faces a challenge similar to that of Medicare Part D drug plans to cost-effectively monitor and optimize pharmacotherapy for its older beneficiaries.

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“…As the world's population ages, the number of patients exposed to polypharmacy is increasing [1][2][3]. The increased number of medications used by a patient correlates with poorer compliance, increased risk of drug-drug interactions and adverse drug reactions (ADRs) and increased economic burden [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Combined intervention programme reduces inappropriate prescribing in elderly patients exposed to polypharmacy in primary care

Bregnhøj

Thirstrup

Kristensen

et al. 2008

Eur J Clin Pharmacol

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Polypharmacy: correlations with sex, age and drug regimen

Abstract: PP is widespread in the population. Clinicians and organisers who are responsible for quality assurance programmes should intensify their surveillance of the groups most prone to PP (the elderly and those using analgesics or drugs for cardiovascular disease, anaemia, asthma and diabetes).

Cited by 207 publications

References 21 publications

Influência da renda na associação entre disfunção cognitiva e polifarmácia: Projeto Bambuí

Influência da renda na associação entre disfunção cognitiva e polifarmácia: Projeto Bambuí

Examination of Multiple Medication Use Among TRICARE Beneficiaries Aged 65 Years and Older

Combined intervention programme reduces inappropriate prescribing in elderly patients exposed to polypharmacy in primary care

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