Polypharmacy and Comorbidity Are Associated with a Lower Early Virologic Response in Hepatitis C Patients Treated with First Generation Protease Inhibitor Triple Therapy: A Preliminary Analysis

Juneja, Manie; Euliano, Rebekah; Satoskar, Rohit; Lewis, James H.

doi:10.1007/s10620-013-2812-9

Cited by 10 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The U.S. Center for Medicare and Medicaid Services estimates that polypharmacy costs more than U.S. $50 billion annually. 17 Polypharmacy contributes to health care costs to the patient as well. A retrospective cohort study found that polypharmacy was associated with an increased risk of taking a potentially inappropriate medication, increased clinic visits, and rehospitalization with an approximately 30% increase in medical costs.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and Factors Associated With Polypharmacy Use Among Adult Patients in Saudi Arabia

et al. 2017

View full text Add to dashboard Cite

Background: Polypharmacy is very common in clinical practice, especially among adult patients. The use of multiple medications may increase the risk of adverse drug events, medication cost, and medication errors. In addition, polypharmacy exacerbates treatment complexity, which consequently leads to poor patients' adherence to their medications. Despite being a well-recognized problem, few studies have investigated the prevalence and predictors of polypharmacy in Saudi Arabia. Objectives:The aims of the study were to investigate the prevalence of polypharmacy among adult patients in a tertiary teaching hospital and to determine patients' characteristics that are associated with polypharmacy.Methods: This was a retrospective cross-sectional study using data extracted from the electronic health records database for a period of 6 months between January and June 2016 in outpatient setting. Descriptive statistics were used to analyze the study sample. A multivariate logistic regression model was used to examine the association between different variables and polypharmacy. Statistical analysis software (SAS 9.2) was used to analyze the study data.Results: A total of 17,237 observations (67.2% females) were included in the final analysis. Of these, nearly 54% (n = 9222) of reported observations were found using up to four prescription drugs and the other 46% (n = 8015) were using five or more prescription drugs. Interestingly, the prevalence of polypharmacy use was doubled among adults with hypertension as compared with those without hypertension (odds ratio [OR] = 2.68, 95% confidence interval [CI] = 2.51-2.87). In addition, polypharmacy use was two times more prevalent among adults with diabetes as compared with those without diabetes (OR = 2.31, 95% CI = 1.99-2.28) and five times more prevalent in patient with dementia (OR = 5.57, 95% CI = 1.26-24.7). Moreover, polypharmacy in adult patients was significantly influenced by sex (OR = 1.69, 95% CI = 1.59-1.80) and nationality (OR = 2.15, 95% CI = 2.00-2.31). Conclusions:Polypharmacy is common among adult patients especially those who are older than 60 years. Polypharmacy may affect the overall process of drug therapy. It can be a risk factor to develop undesirable adverse drug events, especially in those with chronic health conditions. A special care should be taken to manage polypharmacy among adults in Saudi Arabia.

show abstract

mentioning

confidence: 99%

“…Polypharmacy is recognized as an expensive practice. The U.S. Center for Medicare and Medicaid Services estimates that polypharmacy costs more than U.S. $50 billion annually 17 . Polypharmacy contributes to health care costs to the patient as well.…”

mentioning

confidence: 99%

Prevalence and Factors Associated With Polypharmacy Use Among Adult Patients in Saudi Arabia

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The placement of a TIPS is also known to decrease CYP3A activity [22, 26] which may have contributed to the hepatic decompensation of the antiviral therapy in our two patients. Polypharmacy is also known to blunt RVR rates among patients receiving first-generation PIs [27].…”

Section: Discussionmentioning

confidence: 99%

Hepatic Decompensation Likely Attributable to Simeprevir in Patients with Advanced Cirrhosis

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…These findings may be explained by the fact that patients presenting more comorbidities and, subsequently taking more drugs at baseline and presenting more DDIs, were less adherent to treatment. In patients receiving pegIFN and RBV, antiviral regimen complexity has been identified as a predictor of SVR and, in a small cohort of patients treated with first generation NS3/4A PIs, polypharmacy and comorbidity were associated with a lower early virological response .…”

Section: Discussionmentioning

confidence: 99%

Drug–drug interactions of telaprevir and boceprevir in HCV‐monoinfected and HIV/HCV‐coinfected patients can modify the adherence

González-Colominas

Broquetas

Retamero

et al. 2014

Liver International

View full text Add to dashboard Cite

show abstract

Polypharmacy and Comorbidity Are Associated with a Lower Early Virologic Response in Hepatitis C Patients Treated with First Generation Protease Inhibitor Triple Therapy: A Preliminary Analysis

Abstract: These preliminary treatment data demonstrate that increased polypharmacy and higher degrees of comorbidity decrease RVR and eRVR rates among patients receiving first generation PI-containing TTx regimens.

Cited by 10 publications

References 28 publications

Prevalence and Factors Associated With Polypharmacy Use Among Adult Patients in Saudi Arabia

Prevalence and Factors Associated With Polypharmacy Use Among Adult Patients in Saudi Arabia

Hepatic Decompensation Likely Attributable to Simeprevir in Patients with Advanced Cirrhosis

Drug–drug interactions of telaprevir and boceprevir in HCV‐monoinfected and HIV/HCV‐coinfected patients can modify the adherence

Contact Info

Product

Resources

About