Polypeptides from traditional Chinese medicine: Comprehensive review of perspective towards cancer management

Jia, Zhuolin; Zhu, Xiaoli; Zhou, Ye; Wu, Jie; Cao, Mayijie; Hu, Changjiang; Yu, Lingying; Xu, Runchun; Chen, Zhimin

doi:10.1016/j.ijbiomac.2024.129423

Cited by 3 publications

(2 citation statements)

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“…These Chinese inventions are inspired by traditional medicine and adopt its terminology and concepts. Although this medicine is recognized as serious and efficient [80][81][82], patents do not provide sufficient proof of the validity of their inventions and most of them need more clinical investigations to rationalize those applications stimulated by traditional uses. In 2022, for example, Zhou prepared a formulation for the treatment of several types of tumors based on plants, including saffron, through aromatherapy [83].…”

Section: Review Of Relevant Patents Related To Saffron and Its Deriva...mentioning

confidence: 99%

The Multifaceted Therapeutic Potential of Saffron: An Overview Based on Research and Patents

Elfardi,

El Boukhari,

Fatimi

et al. 2024

DDC

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Plants and plant extracts have long been acknowledged as valuable resources for the development of therapeutic formulations for various diseases. Among them, numerous plants and plant-derived products have demonstrated cytotoxic and/or anti-tumor properties. Saffron, particularly due to its major compounds, namely crocin, crocetin, and safranal, stands out as a promising candidate in this regard. Our research undertakes a literature review, reaffirming the antioxidant, anti-inflammatory, and, notably, anti-tumor properties of saffron and its major constituents. Additionally, this study examines relevant patent documents, highlighting innovative applications for saffron and its major compounds in cancer therapy. The review discusses the progress in purifying the compounds extracted from saffron and assesses their impact on cytotoxic trial outcomes, the potential synergies between certain saffron compounds and established cytotoxic molecules, and the limitations of the patents examined, particularly concerning reported clinical evidence. Researchers who focus on advances in oncology will know from our findings the evolution of the patent landscape regarding cytotoxic and/or anti-tumor therapeutic applications using saffron or its main compounds. Moreover, investigators can draw inspiration from patents leveraging traditional knowledge, particularly from Chinese medicine, to clarify specific active molecules and their mechanisms of action and can expedite the translation of these findings into clinically relevant interventions, potentially enhancing cancer therapy outcomes.

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Section: Review Of Relevant Patents Related To Saffron and Its Deriva...mentioning

confidence: 99%

The Multifaceted Therapeutic Potential of Saffron: An Overview Based on Research and Patents

Elfardi,

El Boukhari,

Fatimi

et al. 2024

DDC

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“…Regardless of the significant developments in modern medicine, pharmaceuticals resulting from plant and animal species continuously make important contributions to health in terms of the prevention and treatment of numerous diseases [ 1 , 2 , 3 , 4 , 5 ]. Many treatments that are frequently used in Western countries come from Asia, and their popularity is increasing rapidly [ 6 , 7 , 8 , 9 ]. Animal venoms, especially those from insects, have historical usage in scientific research, and are used today as a source of various products and drugs with potential medical applications [ 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Bee Venom: Composition and Anticancer Properties

Gajski,

Leonova,

Sjakste

2024

Toxins

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Among the various natural compounds used in alternative and Oriental medicine, toxins isolated from different organisms have had their application for many years, and Apis mellifera venom has been studied the most extensively. Numerous studies dealing with the positive assets of bee venom (BV) indicated its beneficial properties. The usage of bee products to prevent the occurrence of diseases and for their treatment is often referred to as apitherapy and is based mainly on the experience of the traditional system of medical practice in diverse ethnic communities. Today, a large number of studies are focused on the antitumor effects of BV, which are mainly attributed to its basic polypeptide melittin (MEL). Previous studies have indicated that BV and its major constituent MEL cause a strong toxic effect on different cancer cells, such as liver, lung, bladder, kidney, prostate, breast, and leukemia cells, while a less pronounced effect was observed in normal non-target cells. Their proposed mechanisms of action, such as the effect on proliferation and growth inhibition, cell cycle alterations, and induction of cell death through several cancer cell death mechanisms, are associated with the activation of phospholipase A2 (PLA2), caspases, and matrix metalloproteinases that destroy cancer cells. Numerous cellular effects of BV and MEL need to be elucidated on the molecular level, while the key issue has to do with the trigger of the apoptotic cascade. Apoptosis could be either a consequence of the plasmatic membrane fenestration or the result of the direct interaction of the BV components with pro-apoptotic and anti-apoptotic factors. The interaction of BV peptides and enzymes with the plasma membrane is a crucial step in the whole process. However, before its possible application as a remedy, it is crucial to identify the correct route of exposure and dosage of BV and MEL for potential therapeutic use as well as potential side effects on normal cells and tissues to avoid any possible adverse event.

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Construction of the core symptom cluster management program for patients with lung cancer undergoing chemotherapy: a Delphi study

Zhang,

Luo,

Mao

et al. 2024

Preprint

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Background: In recent years, the incidence of cancer has been on the rise worldwide due to environmental pollution, poor lifestyle habits, and increasing medical diagnoses. In China, the incidence and mortality of lung cancer both rank first among malignant tumors. In the process of cancer diagnosis and treatment, patients with lung cancer experience a serious symptom burden. Inadequate symptom management will aggravate the physical and mental pain of patients, and even delay or interrupt the treatment of the disease. Therefore, it is urgent to provide scientific symptom management programs for medical staff and patients with lung cancer. Objective: To construct the core symptom cluster management program for patients with lung cancer undergoing chemotherapy. Methods: Under the guidance of Symptom Management Theory, the draft program was formed through the literature supplement and clinical expert meeting based on the best evidence summary, and the final program was formed after two rounds of Delphi with 17 experts. Results: The draft program contains 35 entries in 3 time dimensions and 16 intervention dimensions. The final program, formed after two rounds of Delphi, consists of 12 entries in 7 different dimensions. In both rounds, Delphi issued and recovered 17 questionnaires, and the recovery rate was 100%. The expert authority coefficient was 0.888. The submission rate of expert opinions was 82.35% and 58.82%. The mean values of importance were 3.765-4.647 and 4.410-4.820. The full score frequency was 23.5-76.5 and 58.8-88.2. The coefficient of variation was 0.130-0.280 and 0.110-0.197. The Kendall’s W was 0.467 and 0.523, P < 0.05. The expert approval rate for the clinical usability of each item was 94.1%-100%. Conclusion: Under the guidance of Symptom Management Theory, the core symptom cluster management program for patients with lung cancer undergoing chemotherapy established in this study is scientific and credible, with clinical operability, and can guide medical staff and patients with lung cancer to carry out symptom management in complex clinical environments.

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Polypeptides from traditional Chinese medicine: Comprehensive review of perspective towards cancer management

Cited by 3 publications

References 93 publications

The Multifaceted Therapeutic Potential of Saffron: An Overview Based on Research and Patents

The Multifaceted Therapeutic Potential of Saffron: An Overview Based on Research and Patents

Bee Venom: Composition and Anticancer Properties

Construction of the core symptom cluster management program for patients with lung cancer undergoing chemotherapy: a Delphi study

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