Polypeptide self-assemblies: nanostructures and bioapplications

Abstract

Polypeptide copolymers can self-assemble into diverse aggregates. The morphology and structure of aggregates can be varied by changing molecular architectures, self-assembling conditions, and introducing secondary components such as polymers and nanoparticles. Polypeptide self-assemblies have gained significant attention because of their potential applications as delivery vehicles for therapeutic payloads and as additives in the biomimetic mineralization of inorganics. This review article provides an overview of recent advances in nanostructures and bioapplications related to polypeptide self-assemblies. We highlight recent contributions to developing strategies for the construction of polypeptide assemblies with increasing complexity and novel functionality that are suitable for bioapplications. The relationship between the structure and properties of the polypeptide aggregates is emphasized. Finally, we briefly outline our perspectives and discuss the challenges in the field.

Secondary‐Structure‐Driven Self‐Assembly of Reactive Polypept(o)ides: Controlling Size, Shape, and Function of Core Cross‐Linked Nanostructures

“…[1][2][3][4] Thes ize,s hape,a nd internal structure of nanosized objects that are obtained by the aggregation of amphiphilic coil-coil block copolymers in ab lock-selective solvent in thermodynamic equilibrium are mainly dictated by the volume ratio of the solvophilic and the solvophobic block. [1][2][3][4] Thes ize,s hape,a nd internal structure of nanosized objects that are obtained by the aggregation of amphiphilic coil-coil block copolymers in ab lock-selective solvent in thermodynamic equilibrium are mainly dictated by the volume ratio of the solvophilic and the solvophobic block.…”

Endocytosis behaviours of nanoparticles with helically decorated ligands

“…tobacco mosaic virus and Poxviridae). This surface topology has been successfully imitated in the substrates of laboratory‐prepared particles . For example, Cai et al .…”

Role of High‐Molecular‐Weight Homopolymers on Block Copolymer Self‐Assembly: From Morphology Modifier to Template

“…Amphiphilic block copolymers (BCPs) are capable of self‐assembling into diverse nanostructures in selective solvents . Tuning morphology of the assembled aggregates becomes one of the key topics for BCPs self‐assembly research, since the morphology of the self‐assembled aggregates influences their properties and application performance . A variety of strategies such as introducing a second component, controlling copolymer composition, and altering self‐assembly condition have been applied to tune the morphology of BCP aggregates .…”