Polyoxovanadates with emerging biomedical activities

Spectroscopic/Computational Characterization and the X-ray Structure of the Adduct of the VIVO–Picolinato Complex with RNase A

“…The development of vanadium complexes (VCs) in areas of catalysis, materials science, biology, and medicinal chemistry is a field of extensive research. 1 VCs possess various biological roles in several living organisms, such as macroalgae, bacteria, and fungi. Ascidians, 2 Polychaetes , 3 and mushrooms 4 developed specific systems for uptake, transport, and storage of V. Moreover, in some of these organisms, V-dependent enzymes, like haloperoxidases or nitrogenases, were found.…”

Tris(2-Pyridylmethylamine)V(O)2 Complexes as Counter Ions of Diprotonated Decavanadate Anion: Potential Antineoplastic Activity

“…Although the anticancer activity of decavanadate is less well known, it is thought to be connected to its inhibition of a range of enzymes, including alkaline phosphatases, ectonucleotidases, and P-type ATPases ( McLauchlan et al, 2015 ; Aureliano 2017 ; Aureliano et al, 2022 ). A recent review indicates the activity of decavanadates in cancer, bacteria, and viruses, including apoptosis, cell cycle arrest, interference with ions transport system, inhibition of mRNA synthesis, cell morphology changes, changes in metabolic pathways, phosphorylase enzyme inhibition and cell signaling, formation of reactive oxygen species, lipid peroxidation, inhibition of viral mRNA polymerase, inhibition of virus binding to the host cell, penetration, and interaction with virus protein cages ( Aureliano et al, 2021 ).…”

“…Numerous organic and inorganic species can be incorporated into POM frameworks, resulting in a wide range of shapes, sizes, and nuclearities, as well as a wide range of catalytic, material science, photochemical, magnetic, and biological properties that have been shown to have excellent antibacterial, antiviral, and antitumoral activity ( Gumerova and Rompel, 2020 ). Decavanadate, as one of the most promising POM members, has received much attention in recent decades due to their pharmacological and biochemical properties, as they play a critical role in biological systems because of their capacity to interact with proteins, enzymes, and cell membranes ( Aureliano et al, 2021 ; Aureliano et al, 2022 ). More than forty years ago, vanadate was discovered as an impurity in commercial ATP derived from horse skeletal muscle by inhibiting sodium pump-action ( Cantley et al, 1977 ).…”

“…POVs have also been shown in vitro to reduce mitochondrial respiration. Researchers should investigate vanadium-containing POV-based nanohybrids rather than pure POVs ( Aureliano et al, 2021 ).…”

In Vitro Antibacterial Susceptibility of Different Pathogens to Thirty Nano-Polyoxometalates

“…These nanocompounds destined to be the active ingredient of the potential pharmaceutical product are considered "smart" because of the way the huge clusters are formed (selfassembling of "block" units which then combine in "wheel" or "ball" structures) [12,[45][46][47][48][49] and how they are modeled to specifically recognize targeted biological substrates. As a result of such properties, about 100 research studies relating POMs to cancer were published in the last decade [50]. These syntheses generate low amounts of chemical residues, being environmentally friendly, as literature data point out that the nanoPOMs' maximal efficiency concentrations are often in the nanomolar range [22,23,51].…”