Polyoxometalate‐Driven Self‐Assembly of Short Peptides into Multivalent Nanofibers with Enhanced Antibacterial Activity

Li, Jingfang; Chen, Zhijun; Zhou, Miaolei; Jing, Jiangbo; Li, Wen; Wang, Yan; Wu, Lixin; Wang, Liyan; Wang, Yanqiu; Lee, Myongsoo

doi:10.1002/ange.201511276

Cited by 43 publications

(38 citation statements)

References 33 publications

(54 reference statements)

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“…Among inorganic nanodrug candidates, polyoxometalates (POMs) are multi- metallic and polyanionic oxides which have shown interesting potential applications as antibacterial, antiviral, antitumoral agents (Rhule et al, 1998 ; Hasenknopf, 2005 ; Bijelic et al, 2018 ). Such biological activity mainly derives from their redox behavior, their biomimetic activity, or from their capability to interact with biological macromolecules through electrostatic interactions (Prudent et al, 2008 ; Li et al, 2016 ). Due to their nanosized dimension and polyanionic charge, indeed, POMs can easily interact with positively charged domains of peptides and proteins, affecting their secondary/tertiary structure and altering their functionalities (Wu et al, 2005 ; Zhang et al, 2008 ; Geng et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Selective Targeting of Proteins by Hybrid Polyoxometalates: Interaction Between a Bis-Biotinylated Hybrid Conjugate and Avidin

et al. 2018

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The Keggin-type polyoxometalate [γ-SiW10O36]8− was covalently modified to obtain a bis-biotinylated conjugate able to bind avidin. Spectroscopic studies such as UV-vis, fluorimetry, circular dichroism, coupled to surface plasmon resonance technique were used to highlight the unique interplay of supramolecular interactions between the homotetrameric protein and the bis-functionalized polyanion. In particular, the dual recognition mechanism of the avidin encompasses (i) a complementary electrostatic association between the anionic surface of the polyoxotungstate and each positively charged avidin subunit and (ii) specific host-guest interactions between each biotinylated arm and a corresponding pocket on the tetramer subunits. The assembly exhibits peroxidase-like reactivity and it was used in aqueous solution for L-methionine methyl ester oxidation by H2O2. The recognition phenomenon was then exploited for the preparation of layer-by-layer films, whose structural evolution was monitored in situ by ATR-FTIR spectroscopy. Finally, cell tracking studies were performed by exploiting the specific interactions with a labeled streptavidin.

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Section: Introductionmentioning

confidence: 99%

Selective Targeting of Proteins by Hybrid Polyoxometalates: Interaction Between a Bis-Biotinylated Hybrid Conjugate and Avidin

et al. 2018

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“…Wu et al constructed multivalent peptide nanofibers by using short peptides with the synergistic effect of POM clusters [44]. The short peptide L1 adopts a random-coil conformation in aqueous solution, while with the addition of H 4 SiW 12 O 40 (HSiW), the conformation transition from a random-coil to a β-sheet state (Figure 6a, e).…”

Section: Pom-biomolecule Isa Materialsmentioning

confidence: 99%

Supramolecular Materials Based on Ionic Self‐Assembly: Structure, Property, and Application

Shen¹,

Yuan²,

Xin³

2017

Molecular Self-Assembly in Nanoscience and Nanotechnology

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The technique of ionic self-assembly (ISA), on the basis of electrostatic interactions, is a powerful tool to create new material nanostructures and chemical objects due to its advantages of facility, reliability, cost saving, flexibility, and universality. It has attracted great attention because of its promising applications in catalysis, drug delivery, and molecular detection. This review focuses on recent advances in the construction of self-assemblies with different morphologies on the basis of ISA strategy and its applications. The ISA method provides an opportunity to generate complex and hierarchical assemblies with tunable properties, which is regarded as a very promising case of supramolecular chemistry.

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“…Polyoxometalates (POMs) are a large family of metal oxide cluster anions with different applications in magnetics 1 2 3 4 , material 5 6 7 8 9 , catalysis 10 11 12 13 , and medicine 14 15 16 17 18 19 20 21 22 23 24 25 . Among them, the medicinal chemistry of POM is of great interest because various POMs can exhibit effective anticancer 15 16 17 , antiviral 18 19 and antibacterial 20 21 22 performances by inducting cell apoptosis and inhibiting ATP generation 15 . Recently, many research works have revealed that a variety of POMs are capable of penetrating across the blood brain barrier (BBB) 23 24 25 , endowing POMs with opportunity to be available agents for brain diseases.…”

mentioning

confidence: 99%

“…In the medicinal chemistry of POMs, previous works on cancer therapy were mainly focused on the heteropolyacids, including Keggin 14 19 20 21 and Wells-Dawson 23 24 25 . However, these POMs are stable in vivo and cannot be timely excreted, causing the side effect.…”

mentioning

confidence: 99%

Degradable Organically-Derivatized Polyoxometalate with Enhanced Activity against Glioblastoma Cell Line

She

Bian

Huo

et al. 2016

Sci Rep

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High efficacy and low toxicity are critical for cancer treatment. Polyoxometalates (POMs) have been reported as potential candidates for cancer therapy. On accounts of the slow clearance of POMs, leading to long-term toxicity, the clinical application of POMs in cancer treatment is restricted. To address this problem, a degradable organoimido derivative of hexamolybdate is developed by modifying it with a cleavable organic group, leading to its degradation. Of note, this derivative exhibits favourable pharmacodynamics towards human malignant glioma cell (U251), the ability to penetrate across blood brain barrier and low toxicity towards rat pheochromocytoma cell (PC12). This line of research develops an effective POM-based agent for glioblastoma inhibition and will pave a new way to construct degradable anticancer agents for clinical cancer therapy.

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Polyoxometalate‐Driven Self‐Assembly of Short Peptides into Multivalent Nanofibers with Enhanced Antibacterial Activity

Cited by 43 publications

References 33 publications

Selective Targeting of Proteins by Hybrid Polyoxometalates: Interaction Between a Bis-Biotinylated Hybrid Conjugate and Avidin

Selective Targeting of Proteins by Hybrid Polyoxometalates: Interaction Between a Bis-Biotinylated Hybrid Conjugate and Avidin

Supramolecular Materials Based on Ionic Self‐Assembly: Structure, Property, and Application

Degradable Organically-Derivatized Polyoxometalate with Enhanced Activity against Glioblastoma Cell Line

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