Polyoxometalate Clusters Integrated into Peptide Chains and as Inorganic Amino Acids: Solution‐ and Solid‐Phase Approaches

Abstract

General synthetic methods for the grafting of peptide chains onto polyoxometalate clusters by the use of general activated precursors have been developed. Using a solution-phase approach, pre-synthesized peptides can be grafted to a metal oxide cluster to produce hybrids of unprecedented scale (up to 30 residues). An adapted solid-phase method allows the incorporation of these clusters, which may be regarded as novel hybrid unnatural amino acids, during the peptide synthesis itself. These methods may open the way for the automated synthesis of peptides and perhaps even proteins that contain "inorganic" amino acids.

Self‐Assembled Multinuclear Complexes Incorporating 99mTc

“…As expected, we observed the formation of a 99m Tc compound (g-trace) with ar etention time equal to the one from the reaction of pure 99 Tc ( b --trace). The equal retention times confirmed the formationo f[ 99 Tc 99m Tc (m 2 -O^N-Hsal-m-tol) 2 (CO) 6 ]. The equal retention times confirmed the formationo f[ 99 Tc 99m Tc (m 2 -O^N-Hsal-m-tol) 2 (CO) 6 ].…”

“…The topologya nd the functional groups mimicp harmaceutical lead structures of known activity as in the case of ferrocifen, ferroquine or protein kinase inhibitors of the staurosporine type. [6] In the context of this report, we understand clusters as polynuclear compounds in which two (or more) metal cations are bridged by as ingle atom,f or example, an oxygen atom, which may belongt oalarger ligand framework or not, and compounds with metal-metal bonds. It has recently been pointedo ut that the respective chemistryi sn ot exploredt oasufficient extenta nd the potential behind rhenium complexes might be much brightert han previously assumed.…”

Understanding the Regioselective Hydrolysis of Human Serum Albumin by Zr(IV)-Substituted Polyoxotungstates Using Tryptophan Fluorescence Spectroscopy

“…These molecules are an assemblage of oxo-bridged early transition metals (mostly Mo, W, and V) in their highest oxidation state [13,14]. Their chemical and physical properties can be tuned, giving rise to a large number of possible applications in the fields of catalysis [15][16][17], material science [18][19][20] and medicine [21][22][23][24]. Moreover, the removal of one or more of the addenda atoms from the POM framework results in the formation of a lacunary species, which can coordinate different metal ions, resulting in the formation of metal-substituted POMs [11,25].…”

Atomically precise organomimetic cluster nanomolecules assembled via perfluoroaryl-thiol SNAr chemistry

“…Here we report a new strategy for building robust atomically precise hybrid nanomolecules using air-stable inorganic clusters 24–28 densely decorated with perfluoroaromatic functional groups. Using this organomimetic strategy 29 , we show that one can mimic the rigid surface of a Au-based nanoparticle core while producing assemblies that are fully covalent and thus stable under relatively harsh conditions (Fig.…”